Objective To investigate the apoptosis rate and the mRNA and protein expressions of Bcl-2 and Bax in the remained HepG2 cells after successive thermotherapy for 10 days.Methods After the HepG2 cells were treated with ten repeated cycles of heat exposure at 43℃ for 80 minutes twice a day,the rate of apoptosis was analyzed,and the mRNA and protein expressions of Bcl-2 and Bax were detected.Results Before and after treatment with heat,the apoptosis rates of HepG2 cells were(9.0%?0.8%) and(5.8%?1.3%) respectively(P