Objective To study the clinical effect of nourishing kidney, securing essence and cooling blood on incipient diabetic nephropathy. Methods A total of 110 patients with incipient diabetic nephropathy were randomly recruited into a treatment group and a control group. The treatment group was treated with the method of nourishing kidney, securing essence and cooling blood and benazepril hydrochloride tablets. The control group was treated with bcnazepril hydrochloride tablets Exclusively. Urina microalbumin was detected in all patients 24 h before and after treatment. Results The effective rate was 94.7% and 86.8% in the treatment group and the control group respectively, showing significant difference (t= 9.31, P<0.01) . Conclusion The method of nourishing kidney, securing essence and cooling blood is effective to decrease urina microalbumin in incipient diabetic nephropathy.

The connotation of theory of "kidney dominating bone" is quite clear,but theory of "Shaoyang dominating bone " has an obscure meaning.The causes are analyzed as followings:insufficient explanation in Huangdineijing (Huangdi's Internal Classic),controversial original texts,unclear clinical indications and no unified opinion on theoretical interpretation made by later physicians.The theory of "kidney dominating bone" stresses on growing of bone,refers to a single and clear meaning.However,the theory of "Shaoyang dominating bone" stresses on the using of bone,including liver blood,kidney essence,qi and blood,meridians and the coordination of bones and muscles,is a wide range of theoretical category which is difficult to be clarified.It is possible that the ancients intended to make an obscure meaning of the theory of "Shaoyang dominating bone".