OBJECTIVE:To facilitate personalize information service in pharmacology by means of the personalized service functions of PubMed/Medline.METHODS:We reviewed the development process and the functions of My NCBI in the personalized information service in PubMed/Medline.RESULTS:The personalized information service in pharmacology can be achieved by using the multi-functions of PubMed/Medline which included My NCBI,RSS,E-mail,SMS and PDA downloads.CONCLUSION:My NCBI,RSS,E-mail,SMS and PDA downloads、the multi-functions of PubMed/Medline can be counted on to achieve personalized information service.

There are excellent medical ethics dealing with the relationship between doctors and patients in ancient China.This paper elaborated them from respecting for life, loving to save; skill specialization, theory and practice both excellent;gentle demeanor, gentle humility;universal equality;honest and upright, etc.Them provide reference for improving the doctor-patient relationship, medical personnel professional moral esteemremodeling.

15 consecutive eyes of 13 patients with kerato- conus were treated with radial keratotomy and follo- wed up periodically about 1 year.The visual acuity of all eyes was improved significantly,in the early stage after surgey.The 12 eyes were examined one year postoperatively,1 eye maintainning good result,5 eyes obtainning some improvement of vision and flatt- ening of central cornea,6 eyes of which 4 had adv- anced corncal cones gainning no visual benefit from the surgery.Radial keratoto my appears to be effec- tive in early case of keratoconus,however the long- term result is still not known.

Objective To observe the myocardial injury attributed to cardiopulmonary resuscitation, and to evaluate the impact of 4 ℃ saline perfusion on the ultra structure of myocardium. Method Twelve Pekimg white swine were induced to make models of ventricular fibrillation by direct current shock. Cardiopulmonary resuscitation was initiated 4 minutes after ventricular fibrillation established, and 10 swine survived from resuscitation. These swine were randomly(random number ) divided into hypothermia group ( n = 5) ( 4 ℃ saline infusion to lower the temperature) and control group ( n = 5). Haemodynamics were monitored. And ultra structure of myocardium was observed under electron microscope 24 hours later. The Mann-Whitney test was used to compare the consecutive variables of 2 samples. Results The damage to the ultra structure of myocardium, myofilaments and mitochondria, was found in the control group, while that to a much lesser extent in the hypothermia group was observed. Conclusions After cardiopulmonary resuscitation, 4 ℃ saline infusion has a protective effect on myocardium.

Guided by good clinical practice ( GCP) , M hospital cooperated with the Ethics Committee in quali-ty management of clinical trials and took the specific measures including perfecting the institution and standard op-erating procedures, implementing three level quality control institution, strengthening the training of GCP, and closely cooperating with drug and data management of clinical trials, quality control in the clinical trial, ethical re-view and supervision, quality control in the whole process (seamless connection). Seamless connection from the beginning of project acceptance and quality control in the whole process of clinical trials can effectively solve the ex-isting problems in clinical trials and improve the quality of clinical trials.

Objective To improve the awareness of rare mixed prostatic carcinoma. Methods We reviewed the clinical data of 5 patients with prostatic mixed tumor and relevant literature to ex-plore diagnosis and treatment for it. Results Patient 1 with mixed small cell carcinoma and adeno-carcinoma of the prostate who underwent transurethral electrovaporization of the prostate (TUVP) and flumamide therapy died of lung metastasis 7 months later. Patient 2 with mixed small cell carcinoma and adenocarcinoma of the prostate who underwent TUVP and bilateral testicular resection died of lung metastasis 10 months later. Patient 3 with adenosquamous carcinoma of the prostate who underwent TUVP, radiation therapy and flumamide therapy died of multiple organ failure 8 months later because of the lung, liver, and multiple bone metastasis. Patient 4 with prostatic adenosquamous carcinoma who underwent cystoprostatectomy combined with urinary diversion has already survived for 1 year. Patient 5 with prostatic carcinosarcoma who underwent cystoprostatectomy, urinary diversion, pelvic lymphadenectomy, and radiation therapy died of lung metastasis 13 months later. Conclusion Mixed prostatic carcinoma is quite aggressive with bad prognosis. Its diagnosis relies on detailed pathological examination and immunohistochemical techniques. Patients with prostate adenocarcinoma should be followed up timely after endocrine treatment or radiotherapy. Radical surgery is most effective for mixed prostatic carcinoma.

Magnetic compression anastomosis (MCA)involves the use of two rare-earth magnets that attract to each other transmurally between two internal organs, resulting in compression and subsequent fistula formation to create a nonsurgical enteric, vascular, or biliary anastomosis with therapeutic aims. The magnetic vascular coupler allows a sutureless anastomoses between arteries and veins by using interventional radiological techniques. The MCA technique significantly reduces ischemic time during anastomosis, and has the advantages of low invasiveness and simplicity. It is a rather effective method for recanalizing between various hollow viscera, creating anastomosis such as gastrojejunostomy, choledochojejunostomy, or choledochoduodenostomy.Furthermore, this novel technique is considered to be a feasible and alternative reconstructive method for patients who develop significant bile duct complications following hepaticojejunostomy and living donor liver transplantation. MCA is a promising and novel technique in the further development of minimal invasive surgery.

It is estimated that there are about 0. 17 billion HCV infection cases worldwide. HCV sub-genotype 1b and 2a have been the most common genotypes found in the mainland China. The positive rate of HCV antigen in hepatocellular carcinoma (HCC)/corresponding non-cancer liver tissues in China is between 36. 2% (25/69)-72. 7% (48/66), which is associated with different detection methods. HCV associated HCC usually occurs along with chronic hepatitis→cirrhosis pathway. There was no doubt a correlation between the expression of HCV antigen and liver cell transformation, and the change of the functions of tumor-associated genes. These results show HCV is an important risk factor for development of HCC.

Objective To approach the characteristics of low-field MRI in early stage of cerebral hemorrhage.Methods 38 cases with early stage of cerebral hemorrhage (superacute stage in 26 and acute stage in 12) underwent low-field MRI examination.Results The hematomas located in the basal ganglia regions in 23,thalamus in 9 and other intracerebral regions in 6.The hematomas appeared as reniform,suborbicular or irregular shape with different size.The hematomas exhibited homogeneously iso-intensity on T_1WI and iso-,slightly high or high signal intensity on T_2WI and FLAIR,in which 5 hematomas exhibited iso- or slightly high signal intensity on T_2WI,and 4 hematomas exhibited homogeneously or inhomogeneously high signal intensity on DWI.There was brain edema around the hematomas.25 hematomas had occupied effect,and 4 hemotomas broke into ventriculus and 2 hemotomas caused by hemorrhage of broken arteriovenous malformation.Conclusion Low-field MRI is of high sensitivity and specificity in diagnosis of early stage of cerebral hemorrhage.

Recent studies about the GCT are focusing on searching for new standards and indexes to prognose the biological behavior of the GCT because of the traditional standards and indexes have been realized often not agree with to the clinic. we review the lately research about the biological behavior of the GCT, then analyse and sum up the correlative indexes that could be significant in studying the prognosis of the GCT.