1.Skin toxicities of epidermal growth factor receptor inhibitors
Journal of International Oncology 2012;39(10):784-787
Skin toxicities are the most common adverse effects of epidermal growth factor receptor inhibitors(EGFRI).It can result in significant physical and psyehological discomfort,and even leads to interruption or dose modification,and consequently affect the curative effect. Nowadays this adverse effect has attracted lot of attention.It is proposed that clinical management and treatment measures for skin toxicities should be further studied to improve the patients life quality,and guarantee the continuity and best curative effect of the treatment.But more researches on the pathogenesis and its prognostic significance are still expected.
2.Clinical medical education guarantee mechanism of assessment and practical teaching structure
Chinese Journal of Medical Education Research 2011;10(1):90-93
Due to the cultural lack in second documents'analysis of medical tangle,and the clinical teachers'three bases weakening,the facts that medical students fail to devote to communication between hospitals and patients,and the disjunction between the practice outline and clinical practice,trigger the reflection on the teaching professional level and the educational quality.First,we carry out the systematic construction of chnical practice teaching which includes aim orientation,curriculum design,resource integration,quality management and effectiveness evaluation.Second,we inelusively develop clinical professional skiUs and humanist accomplishment.Above all,we take the initiative to conform the teaching,including knowledge,technology,methods,and implement,to the incubation containing virtue,group,labor and pleasing,all of which promote a variety of needs of study and teaching
3.Relationship between BRCA1 protein expression in lung cancer tissues and the efficacy of chemotherapy
Chinese Journal of Biochemical Pharmaceutics 2017;37(2):297-299
Objective To investigate the relationship between BRCA1 protein expression in lung cancer tissues and the effect of gemcitabine and Cisplatin based chemotherapy.Methods 80 cases of squamous cell carcinoma confirmed by pathology from May 2013 to May 2015 were selected, and treated with gemcitabine plus cisplatin chemotherapy and Ginseng and Astragalus assisted theropy.BRCA1 protein expression of all patients were detected, and relationship between the effect of chemotherapy and prognosis of patients with BRCA1 protein expression in lung cancer tissues were studied.Results In 80 cases, BRCA1 protein was positive in 40 cases, 40 cases were negative, CR 5 patients, PR 6 patients with BRCA1 positive expression, the remission rate was lower than the BRCA1 negative patients ( P <0.05 ) .80 cases of adverse reactions were seen as leukopenia, gastrointestinal symptoms (nausea and vomiting), abnormal liver function, BRCA1 expression of peripheral neurotoxicity, the incidence of complications in patients with positive expression were significantly higher than BRCA1 negative patients(P<0.05).N stage (P=0.03), BRCA1 gene (P=0.02) were independent risk factors of the prognosis of patients.Conclusion BRCA1 protein positive patients in lung cancer tissue had poor chemotherapy effect, more adverse reactions, and poor prognosis.
4.Progress of predicting response to immunosuppressive therapy in aplastic anemia
Chinese Journal of Applied Clinical Pediatrics 2017;32(3):235-237
Aplastic anemia is a severe hematological disease characterized by bone marrow failure and pancyto-penia.Immunosuppressive therapy(IST)with antithymocyte globulin(ATG)and cyclosporine A(CSA)is the first -line treatment for patients who lack an HLA -matched sibling.One third of the patients has no response to IST and the high risk of ATG -related adverse effects may lead to ATG -related death.So it is necessary to explore the predictive marker of response to IST.A defined predictive marker may make the selection of treatment more reasonable and further improve the long -term efficacy.The relevant literatures were analyzed and summarized in recent years,in order to pro-vide a reference for clinical treatment and a baseline for prospective studies.
5.Research and practice on educational guarantee mechanism of clinical medicine
Chinese Journal of Medical Education Research 2006;0(10):-
Faced with the rate’s drop of the Chinese clinical graduates’physician qualification examination and the experimental evaluation feedbacks from global medical education standard, we set up a research in clinical teaching bases’educational guarantee mechanism of medical colleges and universities. With the action research method and the descriptive studies in the definition of guarantee mechanism, the demand of graduates, the system of clinical lectures and the revolution of teaching mode, the standard of education, the system of basic condition datadetection, and the planning and the policy of clinical teachers’growth, we constructed the technical route of the leader’s supporting responsibilities, the teachers’professional roles and the students’ clinical teaching bases’ quality. We applied an empirical study in affiliated and non-affiliated hospitals of western and Chinesetraditional medicine and achieved predicted effort.
6.Intercultural research in standard patients’vocational forms
Qiuchen LU ; Zongbao XIE ; Lu YE
Chinese Journal of Medical Education Research 2003;0(02):-
International services trade in the light of the principles of WTO makes a dif-ference in medical domain when confronting the direction of the global educational services. The Ministry of Education Project,"The Research of medical distance education and practice pattern in rural areas in west China",establishes an educational platform of modern service in central China, invests nursing human resources of west China and outputs vocational standard patients in east China,which provides school of medicine,especially English class of Chinese system,with abundant social teaching resources and has been adopted as Shanghai Human Resources Training Project.
8.Analysis of reproductive performance after loop electrosurgical excision procedure for the management of CIN3
Yong XIE ; Wen-Qiong LU ;
Chinese Journal of Primary Medicine and Pharmacy 2006;0(08):-
Objective To investigate the effects of loop electrosurgical excision procedure(LEEP) on preg- nancy and delivery outcome in patients with CIN3.Methods Fifty-eight patients with CIN3 who were considering future pregnancies underwent LEEP from January 2003 to December 2006,and their following reproductive perfor- mances and delivery outcomes were observed.Results The mean time of the follow-up survey was 21 months(range from 6~42 months).There were 34 cases getting intrauterine pregnancies and 4 cases getting ectopic pregnancies. Among the 34 cases of intrauterine pregnancies,4 terminated by induced abortion and 1 by delayed abortion in early stage.21 cases delivered termed baby vaginally and 7 underwent cesarean section.No cervical dystocia had been re- ported.No disease recurrence had been found until the end of follow-up survey.Conclusion Loop electrosurgical ex- cision procedure is a safe and effective treatment for patients with CIN3.It will not effect the pregnancy and delivery outcome after LEEP.
9.Effect of Naoxueshu oral liquid on cerebral hemorrhage caused by hypertension
Ming LU ; Ru-ping XIE ; Yu FU ; Daozhen XIE
Chinese Journal of Rehabilitation Theory and Practice 2004;10(5):304-305
ObjectiveTo investigate the effect of Naoxueshu oral liquid on cerebral hemorrhage caused by hypertension. Methods140 patients with cerebral hemorrhage were randomly dividied into two groups with a 1∶1 ratio,treatment group and control group. Patients in treatment group received Naoxueshu oral liquid 30 ml daily,while that in control received Naoxuekang oral liquid 30 ml daily. The changes of score on Chinese medical integration,National Institutes of Health (NIH) Stroke scale and the volume of intracranial hemorrhage were evaluated before and a month after treatment.ResultsThe decrease of NIH score of patients in treatment group was (12.73±3.94),but(4.72±3.01) with the control's (t=13.5327,P<0.001). The decrease of the volume of intracranial hemorrhage of patients in treatment group was (13.28±4.17) ml,but (8.37±7.24) ml with the control's(t=4.9228,P<0.001). ConclusionComparing with Naoxuekang,Naoxueshu can accelerate absorption of hematome and ameliorate the recovery of neurological disability more efficiently.
10.Compare anti-tumor activity and antioxidant activity of F.velutipes and A.auricula
Lu WANG ; Mingyue LIU ; Kunpeng XIE ; Mingjie XIE
Chinese Journal of Biochemical Pharmaceutics 2016;36(12):46-48
Objective To compare the anti-tumor activity and antioxidant activity of ethanol extracts of F.veluties and A.auricula.Methods Three human carcinoma cell lines, including MCF-7, HeLa and A375 were assessed by MTT assay to measure cell viability.The antioxidant activity was detected with a DPPH and RFAP assays.Results Two domestic fungus have different anti-tumor activity on the inhibition of MCF-7, HeLa and A375 cells at 25-400μg/mL concentration rage.F.velutipes was better than the A.auricula.The difference was statistically significant ( P<0.05 ).Compared with the control group, the inhibition of F.velutipes were 48.20%, 52.61%and 50.58%at the concentration of 400μg/mL, respectively (P<0.01).At the same concentration, the inhibition of A.auricula were 37.62%、50.21%and 41.59%, respectively (P<0.01).The ethanol extracts of two domestic fungus have significant antioxidant activity.F.velutipes was better than the A.auricula.The difference was statistically significant ( P<0.01 ).Compared with the control group, the scavenging radical capacities on DPPH of ethanol extracts of F.velutipes and A.auricula were 60.30%and 40.43%at the concentration of 1.6 mg/mL, respectively (P<0.01).At the same concentration FRAP value were 9.5 and 7.0 mmol/mL(P<0.01).Conclusion The F.velutipes and A.auricula both have strong anti-tumor and antioxidant activities, F.velutipes is better than A.auricula.