Objective: This study aimed to evaluate the effects of combination of curcumin and piperine supplementation on Fasting Plasma Glucose (FPG), Homeostatic Model of Insulin Resistance (HOMA-IR), Body Mass Index (BMI) in patients with prediabetes and type 2 Diabetes Mellitus (T2DM). This review was done to identify potential herbal remedies that may help improve glycemic parameters, leading to better health outcomes in combination with current antidiabetic treatment. Methodology: This systematic review was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). It was conducted in 2023 with sources and databases from MEDLINE, EBSCO-Host, ScienceDirect and ProQuest. This paper included randomized-controlled trials exploring the effects of the combination of curcumin and piperine on patients with prediabetes and T2DM. Systematic reviews, observational studies, case reports, case series, conference abstracts, book sections, commentaries/editorials, non-human studies and articles with unavailable full-text and written in non-English language, were excluded. The key terms for the literature search were “curcumin,” “piperine,” “prediabetes” and “Type 2 Diabetes Mellitus.” We use Cochrane Risk of Bias (RoB) 2 for quality assessment of the included studies and Review Manager (RevMan) 5.4 to do the meta-analysis. Results: A total of three studies were included in this systematic review. Two studies from Neta et al., and Cicero et al., showed no significant difference in HOMA-IR, BMI and FPG levels between the curcumin, piperine and placebo groups. One study from Panahi et al. demonstrated a significant difference in BMI levels between the curcumin and piperine and placebo groups (p <0.01). The meta-analysis showed that FPG levels, HOMA-IR and BMI improved among patients with diabetes given in curcumin and piperine with reported mean differences (MD) of = -7.61, 95% CI [-15.26, 0.03], p = 0.05, MD = -0.36, 95% CI [-0.77 to 0.05], p = 0.09, and MD = -0.41, 95% CI [-0.85 to 0.03], p = 0.07, respectively). Conclusions The supplementation of curcumin and piperine showed a numerical reduction in FPG, HOMA-IR and BMI, but were not statistically significant. Further research is needed as there is a paucity of studies included in the review.
Curcumin ; Prediabetic State ; Diabetes Mellitus, Type 2

Introduction: Hyperlipidemia is a condition that may lead to many illnesses. The worldwide prevalence of hyperlipidemia is still relatively high. Lactoferrin is a glycoprotein found in mammals and fishes’ epithelial mucosa cells, also known for its protective roles. Objective: This study aims to d Objective: This study aims to discover the histopathologic changes in rat’s liver after the intervention of 100, 200, and 400 mg/kgBW lactoferrin. Method: This study involved 30 Sprague-Dawley rats divided into six groups: normal, negative control, statin-treated, dose 1, dose 2, and dose 3. The normal group was given standard feed, while the other groups were hyperlipidemic induced by a high cholesterol diet. The intervention for the statin-treated group was 1.5 mg/kgBW statin, while dose 1, 2, and 3 were respectively given 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW of lactoferrin. After six weeks, all rats were dissected, and the livers’ histopathologic slides were scored with Manja Roenigk scoring. Result: Lactoferrin improved the fatty liver condition. The statistical test results showed that 200 mg/kgBW of lactoferrin caused a significant change in the rats’ liver structures (p < 0.05). Conclusion 200 mg/kgBW of lactoferrin significantly improved the histopathologic structure of fatty liver
Histology