Objective:To investigate the improving effect of simvastatin on the related indices of hyperlipidemia Patients at the early stage in Talimu oil field, and analyze the correlation between the pulse wave velocity ( PWV) and the other indicators. Methods:Totally 59 patients with hyperlipidemia in Talimu oil field hospital received simvastatin for 6 months. The systolic and diastolic blood pressure, high-sensitivity C-reactive protein (hs-CRP), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol ( LDL-C) , PWV and ankle-brachial index ( ABI) were assessed before and after the treatment. Moreo-ver, the correlation between PWV with the other factors were analyzed by a multiple linear regression method. Results: After the six-month treatment, the systolic and diastolic blood pressure showed no significant change;TC and LDL-C were significantly decreased ( P<0. 05), while HDL-C was increased. PWV was significantly decreased, and ABI was improved significantly (P<0. 05). The chan-ges in PWV were correlated with age and hs-CRP(P<0. 05 or P<0. 01). Conclusion:Simvastatin can significantly improve the relat-ed indices in the patients with hyperlipidemia, reduce PWV, increase ABI and decrease serum hs-CRP level. The determination of PWV and hs-CRP can predict the degree of atherosclerosis better, which plays an important role in the prevention of cardiovascular dis-eases.

In order to understand the roles of the other subunits, we investigated expression of the NMDA receptor subunits (NR2A and NR2B) in visual cortex of normal and anisometropic amblyopia kittens with different ages in the present study. We examined the expressions of NR2A and NR2B in the visual cortex of the kittens by immunohistochemistry with polyclonal anti-NR2A antibody and anti-NR2B antibody, respectively. Using immunohisto-chemical Streptavidin Perosidase (SP) method, we observed the dynamic changes of NR2A and NR2B with microscope and computer-assisted image analyses. We found that NR2A and NR2B remained low expression after the peak of the critical period of kitten visual development; compared with normal group of the same age, NR2A expresses low. However, the difference is not significant for NR2B before maturation period of visual development. NR2B rises after the maturation period of visual development. According to this, the component of NR2A and NR2B can be affected by anisometropia. This research suggests that the difference of NR2A and NR2B expressions may affect the formation of amblyopia.
Amblyopia ; metabolism ; Animals ; Cats ; Female ; Male ; Receptors, N-Methyl-D-Aspartate ; genetics ; metabolism ; Vision, Ocular ; physiology ; Visual Cortex ; metabolism