Despite the proven benefit of cryotherapy in the management of threshold retinopathy of prematurity (ROP), it was shown leading to ocular adverse effects. A male infant was born at 28 week of gestation with a birth weight of 1200 g. Serial examinations revealed worsening ROP in both eyes until he reached a high risk pre-threshold ROP in his right eye and threshold ROP in his left eye. Cryotherapy was performed for the threshold ROP in the left eye while the right eye was subjected to further observation. Subsequently, ROP in both eyes regressed without cicatrisation. The patient was followedup over 8 years and refractions showed that the treated eye developed steadily increasing myopia while the untreated eye remained emmetropic. This case demonstrated the detrimental effect of cryotherapy to the treated eye leading to the progressive myopia as the child grew.
Retinopathy of Prematurity ; Cryotherapy

Humans ; Severe Acute Respiratory Syndrome ; pathology ; Specimen Handling

We report a case of infantile fibrosarcoma in an 8-month-old boy manifested as a right-sided lower leg mass. Repeated local recurrence and distant metastasis were noted during the following three-year period. Whole body fluoro-deoxyglucose positron emission tomography scan revealed an asymptomatic metastasis involving the fourth lumbar vertebrae. The patient received chemotherapy (VAC regimen) with Cyberknife(R) stereotactic hypofractionated radiotherapy (26 Gy; 4 fractions). This treatment reduced tumor size by 23% without acute radiation toxicity even after 33 months. This case suggests that combining chemotherapy and this form of radiotherapy may be safe and effective against childhood spinal metastasis.
Drug Therapy* ; Fibrosarcoma* ; Humans ; Infant ; Leg ; Lumbar Vertebrae ; Male ; Neoplasm Metastasis* ; Positron-Emission Tomography ; Radiotherapy* ; Recurrence