1.Effect of Xiang-Qi-Tang on coagulation factors in mice with endotoxemia
Yuting ZHANG ; Yu MA ; Lizi YIN ; Yangping OU ; Gang YE ; Gang SHU ; Bendong FU ; Haiqing SHEN ; Changliang HE
Chinese Journal of Veterinary Science 2017;37(8):1583-1588
To study the anticoagulant effect of Xiang-Qi-Tang (XQT),the mice model of endotoxemia was established to detect the expression of coagulation factors and their regulatory proteins in serum and aorta.The results showed that XQT could decrease the expression of TF and increase the expression of tPA in the aorta of mice with endotoxemia,and also decrease the expression of sEPCR in the serum.We further found that XQT caused the decrease of sEPCR through the regulation of PKC δ and ADAM17 to contribute the anticoagulation in mice.This study may provide a new strategy for treating endotoxin-induced disease and provide evidences for further researching the pharmacological action of XQT.
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