Paraneoplastic retinopathy (PR) is a rare form of paraneoplastic syndrome,it occurs when autoantibodies of neoplasms cross-react with autoantigens in normal retina.PR includes carcinoma-associated retinopathy (CAR),melanoma-associated retinopathy (MAR) and bilateral diffuse uveal melanocytic proliferation (BDUMP).Many kinds of autoantigens are involved in the process of CAR,like recoverin,α-enolase,α-transducin and so on.TRPM1 is a component of an ion channel of bipolar cell,it plays an important role in MAR.There are fewer kinds of antibodies associated with BDUMP,only anti-recoverin and anti-heat shock protein 70 (HSP70) antibodies were found in one particular research.The clinical manifestation of PR includes rapid vision loss of both eyes,photopsia and nyctalopia.The fundus can be normal or mild abnormal.Electroretinogram (ERG) presents various abnormalities based on the type of PR and autoantibody.The treatment of PR mainly targets on the original tumor,meanwhile glucocoticoids,plasmapheresis and intravenous immune globulin are also applied singly or combinedly in clinic.

Objective :More recently ,biological oriented personality research has been a hot is sue and has sought rel atively stable biological traitsassociated with enduring personality features The objective of this study is toexploremedical college student’ssensation seekingtrait and its’biologicaltraits and basis Methods :Seventy -ninecollege students were assessed with MM PIand Sensationsee king scale (SSS)and the ywereal sounder went long latencyauditoryevoked potential studies using to nesat 4 different in ten si ties of 70 ,80 ,90 ,10 0d BSPL Results :1 Rapid habituation ise lectrophy siological trait for highsensation seekers 2 There is a difference between high sensation seekers and lowsensation seekers on the MM PIand SSS Conclusion :1 Veryhig horvery lowsensation seekers are probably related to mania or depressived is orders 2 Compare dtointensity dependence ,rapid habituation is probably a more sensitiveele ctrophysiological trait for high sensation seekers

Objective To explore the clinical effect of extracorporeal shock wave lithotripsy (ESWL) for the treatment of horseshoe kidney stones.Methods A total of 42 cases of horseshoe kidney stones from March 1987 to January 2015 were enrolled.Among them,33 cases were male and 9 cases were female.Their age range was 19 to 71 years,average age was 42 years old.25 cases got left renal pelvis stone,17 cases were on the right renal pelvis side.The diameter range of stone was 0.4-3.7 cm,the average was 1.8cm.ESWL was applied to treat whole group.The prone position was used to removing calculus.The frequency of treatment was 2000-2700 times,with an average of 2500 times;the treatment voltage was 4-7KV.The gravel time of the treatment was 30-45min,the average was 35min.Results One time for ESWL was 29 cases,two times for ESWL was 8 cases,three times for ESWL was 3 cases,four times for ESWL was 2 cases.The first discharge stones time was 3 to 10 days.There was no special discomfort after operation.40 cases got hematuria after operation,which occurred in 1 to 3 days after ESWL Renal colic was in 7 cases which happened on 1-3 days after ESWL.Condusions Calculi in horseshoe kidney may be treated by ESWL.It is a safe and simple operation.The prone position may bring satisfactory effect.

Objective To evaluate clinical efficacy of extracorporeal shock wave lithotripsy (ESWL) for treating patients with double J (DJ) stent extubation difficulties.Methods A retrospective analysis were conducted from July 1999 to December 2013,total 30 cases (18 male and 12 female) were accepted the ESWL therapy for treating the DJ extubation difficult due to the stone scales surface.The average age in those patients was 46 years (range 24 to 83 years).The average duration of DJ stents indwelling was 8.3 months (range 1.5 to 36.0 months).There were 10 cases with single stone and 20 cases with multiple stones.The distribution of stone location included left kidney in 14 cases,right kidney in 6 cases,left ureter in 3 cases and right ureter in 7 cases.The ureteral stone scales around the DJ stent showed tubular distribution.The distribution of imaging characteristic included kidney stones around the DJ stent joint in 20 cases and surface coarse in 10 cases.The diameter of the stone ranged from 0.7 to 3.2 cm (mean 1.8 cm).All the 30 cases were treated by ESWL with the 2 000-3 300 times frequency (mean 2 800 times).Treatment voltage was 4-8 KV.Results Gravel time ranged from 40 to 70 min (mean 45 min).No intraoperative and postoperative complications occurred.Their DJ stents were easily extubated immediately after ESWL.One week after ESWL,all the patients reported the flushing of the stone.Conclusion ESWL is a simple,convenient and efficacy way to solve the DJ stent extubation difficulties due to the scales surface.

Pulmonary hypoplasia (PH) may lead to severe respiratory distress immediately after birth,even neonatal death. The etiological factors, clinical, ultrasonic and pathologic characteristics of PH and the proposed methods for the prenatal diagnosis were reviewed in this article.

This study was aimed to investigate the efficacy ofTong-Bu San-Sheng(TBSS) Decoction to reduce the toxicity and side effects of chemotherapy, as well as prolong progression-free survival (PFS) for advanced lung squamous carcinoma patients who received chemotherapy. A total of 83 lung squamous carcinoma cases were divided into two groups by patients’ wishes. The control group contained 41 cases were treated by the chemotherapy of gemcitabine plus cisplatin (GP). The trial group contained 42 cases were treated by chemotherapy plus Chinese herbal medicine TBSS decoction. The toxicity and side effects of chemotherapy, as well as short-term outcome were evaluated. PFS of patient was recorded. The results showed that there were no differences on granulocytopenia (P = 0.115) or short-term outcome (P = 0.081) for patients of both groups after chemotherapy. The percentages of nausea, vomiting and thrombocytopenia in the trial group were lower than that in the control group (P = 0.037,P = 0.040). The PFS of patients in the trail group were prolonged compared to patients in the control group (4.31 ± 0.24 VS 3.78 ± 0.16 month;P = 0.043). It was concluded that Chinese herbal medicine TBSS decoction cannot reduce granulocytopenia caused by chemotherapy, or improve the tumor response rate (RR) of short-term outcome. However, it can prolong PFS, relieve nausea, vomiting and thrombocytopenia during chemotherapy.

Objective To explore the effects of stress management on the quality of life ( QOL) of patients with chronic pelvic pain syndromes .Methods By convenience sampling method , 60 cases of patients with chronic pelvic pain syndromes in the urology department , were divided into the experimental group and the control group with 30 cases in each group .Patients in the control group were given routine nursing and guidance , while patients in the experiental group were given stress management intervention and health education guidance . National institutes of health-chronic prostatitis symptom index (NIH-CPSI) and quality of life measurement scale ( WHOQOL-BRIEF) were used to measure some index before and after intervention .Results Before the intervention, there was no sigificant difference in the scores of WHOQOL-BRIEF and NIH-CPSI between two groups ( P>0.05 ) .After intervention , the scores of physiological field , psychological field , social field and environment in QOL in the experimental group were (67.85±18.81), (59.37±15.36), (65.27±13.28) and (63.34±17.59), and they were all obviously higher than that in the control group with (51.27±14.96),(56.62± 17.28),(58.36±16.72) and (57.94±14.93) (t=3.276,3.732,2.365,3.210;P<0.05).The total NIH-CPSI score of the experimental group were (16.20±2.18), which was significantly lower than that of the control group (27.16±2.06) (t=19.947,P<0.05).Conclusions Stress management can notablely improve the QOL and symptornsof patients with chronic pelvic pain syndromes .

Objective To explore the effects of the holistic nursing in perioperative nursing among patients with solitary kidney calculi with the treatment of extracorporeal shock wave lithotripsy. Methods A total of 62 patients with solitary kidney calculi in out-patient service of urology department at Peking University First Hospital were selected from January 2014 to January 2016. They were divided into observation group (n=32, holistic nursing) and control group (n=30, routinely perioperative nursing) with the method of the random number table. The psychologic status evaluated by the symptom checklist 90 (SCL-90) and complications was compared between two groups after lithotripsy. Results Compared with that in observation group, the symptom of body discomfort in SCL-90 of patients in control group was significant (Z=6.356, P< 0.05). Moreover, patients in control group were with anxiety and depression (Z=6.407, 6.758; P<0.05). There were 19 patients with gross hematuria and three patients with renal colic in observation group. The incidences of gross hematuria and renal colic were lower than those (25 patients with gross hematuria and 10 patients with renal colic) in control group with significant differences (χ2=4.314, 5.363; P<0.05). Conclusions The holistic nursing can improve the treatment effects of patients with solitary kidney calculi and effectively reduce postoperative complications.

BACKGROUND:Three dimensional finite element analysis is widely used in orthopedics, but research in the knee flexion movement is not much. OBJECTIVE:To analyze biomechanical properties of knee flexion using finite element analysis.METHODS:Three dimensional finite element models and models of knee flexion at 30 degrees, 60 degrees and 120 degrees were established. Femoral forward movement, femur inward movement, tibia internal rotation and tibia vara were analyzed at different flexion angles. RESULTS AND CONCLUSION:(1) When knee flexion was at 30 degrees, 60 degrees and 120 degrees, the femur had backward movement. The backward movement value was larger at 60 degrees than at 30 and 120 degrees (P<0.05). The backward movement value was larger at 120 degrees than at 30 degrees (P>0.05). (2) The femur had outward movement at 30 degrees, and inward movement at 120 degrees. The inward movement value was significantly larger at 120 degrees than at 30 and 60 degrees (P<0.05). No significant difference in outward movement was determined between the 30 and 60 degrees (P>0.05). (3) Tibia internal rotation was not significantly different at 30, 60 and 120 degrees of flexion (P>0.05). (4) Tibia vara was found at 30, 60 and 120 degrees of flexion, but the tibia vara was not obvious at 120 degrees. The tibia vara was maximum at 60 degrees, and significantly higher than that at 120 degrees (P<0.05). The tibia vara was larger at 30 degrees than at 120 degrees (P>0.05). (5) These findings verify that backward movement was most obvious at 60 degrees. Femur inward movement was most large at 120 degrees. Tibia internal rotation was noticeable at 30 and 120 degrees. Tibia vara was remarkable at 60 degrees.