At present,China's description of macrosomia diagnosis is single,Only in the quality evaluation of 4 000 or higher,and BMI,body index can better response body quality development.Macrosomia is related with many factors,and its mechanism remains unknown.Therefore,this article summarized the research status in those aspects of hormones,cell,gene,motherhood diabetes,pregnancy weight,gestational age,and the related factors of macrosomia in order to improve the knowledge of these aspects.

Objective To probe into the chnical value of strain rate imaging on the assessment of left atrial function in patients with hypertensive disorder comphcating pregnancy(HDCP).Methods Thirty two patients with HDCP and 20 control subjects were involved.Patients with HDCP were divided into 2 groups:17 with normal left ventricular mass index (LVMI) and 15 with left ventricular hypertrophy.These patients and controls underwent transthoracic echocardiography,strain and strain rate imaging examination.Atrial strain and strain rate imaging values of patients with HDCP were compared with those of controls.Multiple parameters were compared by one-way anova analysis.Results When compared with the controls,peak early diastolic strain rate (ESR) was significantly decreased in HDCP patients with normal LVMI and left ventricular hypertophy [(-1.13 ± 0.15),(-1.04 ± 0.29) s-1 vs.(-1.26 ± 0.23) s-1,P ＜ 0.05].Compared with the normal LVMI,peak late diastolic strain rate (ASR) was significantly decreased in controls and patients with left ventricular hypertrophy [(-1.23 ± 0.25) s-1 vs.(-1.36 ± 0.33),(-1.34 ± 0.32) s-1].There was no significant difference in the others (P ＞ 0.05).Conclusion Left atrial function is decreased in HDCP patients,which with left ventricular hypertrophy,the tendency is more obvious.

Objective To observe the effect of different periodontal therapies on serum levels of tumor necrosis factor-alpha (TNF-α),interleukin-6(IL-6)and C-reactive protein (CRP)in elderly patients with coronary.Methods Totally 90 elderly patients with severe periodontitis were divided into three groups,the control group performed the treatment of coronary heart disease;the periodontal treatment group performed the treatment of coronary heart disease and periodontal treatment;the combine group per-formed periodontal therapy and flap surgery on the basis of the treatment of coronary heart disease.The obvervational index were compared among three groups.Results All patients′clinical indexes of periodontitis of combination group and basic group has im-proved after treatment,the levels of PD,SBI,CAL,PLI,the percentage of bleeding on probing and probing depth were significantly decreased (P <0.05),and had significant adhesion(P <0.05);the contrast between combination group and basic group,the levels of PD,SBI,CAL,the percentage of bleeding on probing and probing depth had notable difference(P <0.05).All patients′clinical indexes of periodontitis of combination group and basic group had improved after treatment,serum levels of TNF-α,IL-6 and CRP were significantly decreased (P <0.05);the contrast between combination group and basic group,serum levels of TNF-α,IL-6 and CRP have notable difference (P <0.05).Conclusion The periodontal basic therapy and periodontal flap therapy can reduce the ser-um levels of TNF-α,IL-6 and CRP of elderly coronary heart disease (CHD),but compared to the routine medicine maintenance therapy,the effect of periodontal flap therapy is better.

Guasha(scraping) therapy falls into the category of non-medication therapy.It works well for insomnia in clinical practice.

Objective To develop a method for the direct determination of eight life elements (Ca, Mg, K, Al, P, Cu, Zn, Fe ) in serum by ICP-AES. Methods The serum samples were determined by ICP-AES after diluted in 0.1% Triton X-100. Results The RSD of the method were 2.36%-9.46% and the recovery rates were 87.3%-116.5%. Conclusion This method was quick, simple and accuracy, which is suitable for direct determination of life elements in serum samples at one time.

Objective To study the characteristics of complement expression and the effects of atorvastatin on the complement in rats after the cerebral ischemic infarction.Method One hundred and sixty adult healthy Sprague-Daweley rats were randomly divided into normal group,sham-operated group,ischemia group and treat group.The ischemia group and treatment group were sub-devided into 6 h,12 h,24 h,48 h,3 d,5 d,2week,respectively.The middle cerebral artery occlusion(MACO)model was induced by using filament method,and the thread Was withdraw from the middle cerebral artery after occlusion 2 h.Rats in the sham-operated groupdid not have thread inserted.After wakefulness,the animals The successful of animal model produced was evidenced by the paralysis of contralateral limbs.The animals model in the treatment group treated with Atorvastatins 10 mg once a day for 2 weeks and,rats in the ischemia group did not receive Atorvastatin.The neurological deficit scoring was measured at different intervals in the ischemia and treat ment groups.The expressions of complement C1q and C3 d protein in the brain of the rats in 4 groups were measured by immunohistochemical methods.Result There were a few complement expression in the brain of normal rats,showing no significant difference observed between sham-operated group and normal group(P＜0.05).The complements(C1 q and C3 d)expressied increasubgkt after cerebral ischemia injury,peaked 24 h after ischemia,and returned to normal levels 5 d after ischemia.The expression of complement C1 q and C3 d in the ischemia group were significanfly higher than those in sham-operated group(P＜0.05),The expression of complement C1 q and C3 d in treat ment group were signnificantly lower than those in the ischemia group(P＜0.05).The neurological deficit score in treatment group were signnificantly lower than that of ischemia group.Conclusions The expressions of complement C1 q and C3 d were increase gradually after cerebral ischemia in the rats,Atorvastatin Can inhibit the complement activation,improve neuro logical function of rats.

Objective To improve the clinical efficacy of angina pectoris with dyslipidemia patients, analysis of the combined use of trimetazidine, atorvastatin calcium, the clinical value of psychological intervention.Methods 86 cases of patients with coronary heart disease and angina pectoris with dyslipidemia were selected, according to the random number table method is divided into control group and study group, each group of 43 cases. The control group were given routine symptomatic angina pectoris of coronary heart disease with abnormal blood lipid therapy plus trimetazidine hydrochloride oral Sibutramine, study group on the basis of the control group given oral atorvastatin calcium plus psychological intervention of statin treatment. Results After treatment, the clinical efficiency of the study group and the control group was 95.34％ and 81.4％, the difference between the two groups was statistically significant (P<0.05); patients in the study group SDS, SAS score than the control group, the difference between the two groups was statistically significant (P<0.05); patients in the study group, TC, TG, LDL and C levels were significantly lower than the control group, the HDL level of C higher than that of control group, the difference between the two groups was statistically significant (P<0.05); study on patients with angina pectoris attack times less than the control group, the seizure duration shorter than the control group, the difference between the two groups was statistically significant (P<0.05). Conclusion Psychological intervention combined with the treatment of angina pectoris of coronary heart disease with abnormal blood lipid, clinical efficiency increased from 81.4％ to 95.34％, reduced in patients with depression, anxiety and other negative emotions, so that the blood has been effectively controlled, improve clinical symptoms, reduce the pain of patients, with high clinical value.

Objective To evaluate the effect of dexmedetomidine on the intraocular pressure during laparoscopic gastrectomy.Methods Forty ASA physical status Ⅰ or Ⅱ patients of both sexes,aged 34-64 yr,weighing 45-81 kg,scheduled for elective laparoscopic gastrectomy,were randomly divided into 2 groups with 20 patients in each group using a random number table:control group (group C) and dexmedetomidine group (group D).In group D,a loading dose of dexmedetomidine 1.0 μg/kg was infused intravenously over 15 min,followed by continuous infusion of dexmedetomidine at 0.4 μg·kg-1 · h-1 until the end of surgery.In group C,normal saline 0.25 ml/kg was infused intravenously over 15 min,followed by continuous infusion of normal saline at 0.1 ml·kg-1 · h-1 until the end of surgery.Anesthesia was induced with propofol,sufentanil and rocuronium.After tracheal intubation,intermittent positive pressure ventilation was carried out.PET CO2 was maintained at 33-36 mmHg.Anesthesia was maintained with sevoflurane,propofol,cisatracurium and sufentanil.The pressure of carbon dioxide insufflation was maintained at 9-14 mmHg and airway pressure was maintained at 11-23 cmH2O.Intraocular pressure was measured at 5 min after intubation (T1),at 5,30 and 60 min of pneumoperitoneum (T2-4),and at 5,30 and 60 min after pneumoperitoneum (T5-6).Results Compared with the value at T1,intraocular pressure was significantly increased at T2-6 in group C,and intraocular pressure was increased at T3-5 in group D.Intraocular pressure was significantly lower at T3-5 in group D than in group C.Conclusion Dexmedetomidine can decrease the intraocular pressure during laparoscopic gastrectomy.

Objective This study was designed to determine the expression ofgeneproducts of phosphatase and tensin homoligy deleted onehromoseten(PTEN)and DNA content in non small cell lung cancer(NSCLC)tissue and investigate their association with the invasion and metastasis of NSCLC.Methods The expression of PTEN were detected in 78 cases of lung cancer tissues by immunohistochemistry SP methods,DNA content in 30 cases of lung cancer tissues was examined by flow cytometry.Results The rate of total expression depletion of PTEN was 42.3%.The rates of PTEN expression depletion in lymph node metastasis group and no lymph node metastasis group were 52.1%and 26.7%respectively,with significantant difference(P＜0.05).The patients who had high expression of PTEN had a longer survival time.The range of the DNA index(DI)distribution ranged from 1.04 to 1.93,the DNA index and aneuploid tumor had a positive correlation with the lymph node metastasis,with the increased of TNM stage,the DI and the rate of DNA aneuploid increased(P＜0.05).Conclusions Expression of PTEN is associated strongly with lymph node metastasis of lung cancer,correlations exist between DNA content and TNM stage,lymph node metastasis.They are indications of metastasis potential and prognosis of lung cancer.