OBJECTIVE: The application of ambulatory blood pressure monitoring (ABPM) has been a great impetus to clinical hypertension research in respect of the liability, differentiation between high-risk and low-risk patients and the therapeutic effect of antihypertensive drugs. Therefore, in this study we reviewed recent research on ABPM in the prevention and early intervention of hypertension. DATA SOURCF: Related articles were retrieved by computer in the Medline between January 1993 and January 2002, with the key words of 'ambulatory blood pressure monitoring', 'hypertension', 'life satisfaction', 'effect factors'and 'blood pressure monitoring' and the language confined to English. STUDY SELECTION: After the first trial, literature containing research randomized controlled clinical trial and review on the confirmed primary,allel control group. Repetitive studies were excluded. DATA EXTRACTION: We selected a total of 20 articles on the association of ABPM with the prevention and early intervention of hypertension, 7of which accorded with the inclusion criteria. The other 13 articles were excluded because 10 of them had little relevance to the objective of our study and 13 were repetitive studies.DATA SYNTHESIS: ABPM was used to assess general BP profile, the peak level of drug action and lasting time under various states, such as resting, instable emotion, as well as movement and sleep. Then the safe dosage and medication time were draw up according to the peak-effect (the maximum decrement of diastolic pressure and systolic pressure after a dosage administration) and the valley effect (the decreasing amplitude when completing a dosage medication), as well as the relationship between them, aiming to keep the antihypertensive peak-to-valley ratio above 60%,which guaranteed the stable antihypertensive effect within 24 hours and was beneficial to the individualized treatment. CONCLUSION: ABPM can decide whether patients with hypertension need earlier intervention, and has been used in the assessment of therapeutic effect. It is also considered as an important independent predictor for the occurrence of hypertension complications. Twenty-four hours ABPM can not only determine the type of hypertension, but also keep the patients informed of their BP fluctuation profile at any time in order to avoid hypotension when sleeping, thus helping prevent severe hypertension complications such as stroke. Furthermore, ABPM can predict the severity of hypertension, and BP variation and day-night fluctuation, which provides guidance for the early intervention, correct medication and regular life.

To identify the cell wall-binding proteins of Streptococcus suis serotype 2(SS2), according to their structure feature, the substrates of sortase and I type secreted proteins with LysM domain, WxL domain, choline-binding domain,GW domain or S layer homologous domain in the recently published genome of SS2 strain 98HAH33 were firstly identified and then the putative functions were attributed to individual proteins by reference to the identification of conserved domains of InterPro and BlastP servers. Homologous proteins were identified by unfiltered BlastP homology searches (including conserved domain detection). Among the 23 putative proteins with a C-terminal LPXTG recognition signal for covalent attachment to peptidoglycan by sortase, 9 with I signal peptide were identified as sortase substrates. Among 9 substrates , YP_001201232, YP_001201531 and YP_001201656 had been experimentally verified to anchor to bacterial cell wall , and YP_001201232 known as the opacity factor of S. suis (OFS) was proved to be the virulence factors. According to function analysis, YP_001201484, YP_001201544, YP_001199825, YP_001197640, YP_001197840 and YP_001199755 appeared to be involved in SS2 pathogenesis. and YP_001200959, YP_001201233 and two proteins with LysM domain( YP_001199784 and YP_001201729) were the hypothetical proteins. These data suggest the majority of putative sortase substrates may implicate in the virulence of SS2 and could serve as a basis for targeted experimental studies into the function of these proteins.

Objective:To analyze the risk factors on soft birth canal laceration in normal delivery and discuss the reasonable prevention and control measures.Methods:A follow-up study among the mothers, who delivered vaginally at our hospitals during 9-12 months in 2014, and investigate the risk factors on soft birth canal laceration.Results: In this study, the incidence of soft birth canal laceration in normal delivery was 66.12%, by the single factor unconditioned Logestic regression analysis found that emergency birth, primiparity, pregnancy induced hypertension syndrome, macrosomia, malposition, the short gel time, turn the hips to the fore, rotary fetal head, obstructed labor, oxytocin, cervical inflammation, obstetric forceps'application 12 factors were associated with soft birth canal laceration; On the alpha=0.05 level, multiariable unconditioned Logistic regression analysis showed seven factors: emergency birth, macrosomia, malposition, turn the hips to the fore, rotary fetal head, oxytocin, obstetric forceps'application. Conclusion: Emergency birth, macrosomia, malposition, turn the hips to the fore, rotary fetal head, oxytocin, obstetric forceps'application, the seven factors were closely related to the occurrence of soft birth canal laceration, corresponding measures should be taken to reduce and control the incidence of soft birth canal laceration effectively.

Since the State Council approved and issued the law of The People's Republic of China Government Procurement Regulations(Draft),from the perspective of internal control,regarding internal control environment,risk assessment and evaluation,internal control supervision and other elements,it explored and analyzed the existing problems and improvement measurement for government procurement business in public hospitals,summarized the highlights and deficiencies to provide enlightenment for improving internal control level of public hospitals.

Substituting the value-added tax for business tax was one of the main content of the current implementation of structural tax cutting.As the policy fully implemented,it put forward how to strengthen the management of public hospital in tax and accounting cohesion measures around the public hospital tax changes and the resulting effects.

Fcgamma receptors family conclude three groups(CD64、CD32、CD16),of which FcγR Ⅱa,Ⅱb,Ⅲb have Gene polymorphisms,for this reason they have an effect on affinity of FcγR to antibodies different,so FcγRⅡa,Ⅱb,Ⅲb are related to genetic susceptibility and IVIG treatment response.The Gene subtype of FcγR Ⅱ a is considered to be the susceptibility genes of KD.Polymorphisms of FcγRs were intimately connected to pathogenesis,coronary artery impairment and disease prevention of Kawasaki disease.

Tachykinins are potent mediators of many functions in the airways.The tachykinins substance P and neurokinin A,presenting in human airways,can be recovered from the airways after a series of stimuli.They interact in the airways with tachykinin Neurokinin1,Neurokinin2 and Neurokinin3 receptors to cause bronchoconstriction,plasma extravasation,mucus secretion and to attract and activate immune cells and inflammation cells.They play a important role in the pathophysiology of asthma.However,the application of tachykinin receptor antagonists in clinic has been rather slow and somehow disappointing and needs to be further studied.

Objective To evaluate the clinical efficacy of the treatment of idiopathic hyperprolactinemia infertility by Chinese medicine combined with bromocriptine.Methods 80 patients diagnosed of idiopathic hyperprolactinemia infertility were randomly recruited into a control group and a experimental group.The control group was treated with bromocriptine alone and the experimental group was treated additionally with self-designed Bushen Shugan decoction on the basis of the control group.The improvement of the clinical symptoms and follicular development were compared between the two groups.The data of ovulation and pregnancy rate was collected.The serum prolactin level and pregnancy outcomes afterdrug withdrawal was followed up and the recurrences was evaluated.Results The follicular development of the experimental group was improved greatly.Its ovulation rate was 72.5％(29/40),pregnancy rate was 60.0％ (24/40) and recurrence rate was 10.0％ (4/40).The follicular development of the control group was not obvious.Its ovulation rate was 27.5％(11/40),pregnancy rate was 20.0％(8/40)and recurrence rate was 35.0％ (14/40).The difference between the two groups was statistically significant (x2＝ 16.200,13.333,7.168,P＜0.05).Besides,there was no miscarriage,premature delivery and fetal malformations in the experimental group.Conclusion The treatment of idiopathic hyperprolactinemia infertility by Chinese medicine combined with bromocriptine had the characteristics of sound clinical efficacy,little side effect,high ovulation and pregnancy rate,low recurrence and good pregnancy outcomes.

Objective To evaluate the efficacy of laparoscopic surgery combined with sanjiezhentong capsule for endometriosis. Methods Thirty-three cases of endometriosis who accepted conservative surgery were divided into 2 groups: 19 cases accepted treatment of sanjiezhentong capsule (sanjiezhentong capsule group, infertile patients were 9 cases) and 14 cases accepted goserelin (goserelin group, infertile patients were 8 cases ). The treatment of two groups were given drugs on the first day of menstrual onset after operation for 3 months. The effect, side effect and pregnant was compared after treatment. Results The total effective rate of sanjiezhentong capsule group was 73.7%( 14/19) and in goserelin group was 78.6%( 11/14), there had no statistically significant (P> 0.05). The pregnancy rate of secondary infertile patients in sanjiezhentong capsule group was 55.6%(5/9) and in goserelin group was 62.5%(5/8)(P> 0.05). The side effect was lower in sanjiezhentong capsule group than that in goserelin group. Conclusion Sanjiezhentong capsule is a safe and effective drug in treating post-operative endometriosis.

Inflammatory reaction plays an important role in the occurrence and development of ischemic stroke. Monocyte chemotactic protein-1 (MCP-1) is one of the subfamily members of the CC chemokine class. It can attract and activate a variety of cells, such as monocytes and T lymphocytes, promote the expression of cytokines, and participate in the occurrence of ischemic brain injury. This article reviews the progresses on the MCP-1 and ischemic stroke-related research.