Objective To evaluate the value of serum tumor markers in diagnosis and following up of large intestinal cancer(LIC) in the aged patients. Methods Serum CA19-9?CA50?CA242 and CEA in 163 aged patients with LIC and 29 aged patients with benign large intestinal diseases by micropartical enzyme immunoassay were examined,and 42 of them with radical operation was followed up. Results Serum levels of CA19-9?CA50?CA242 and CEA in patients with LIC were (45.2?21.3)?g/L, (29.7?17.6)?g/L, (43.2?37.6)?g/L, (18.7?12.4)?g/L and were significantly higher than those patients with benign large intestinal diseases〔 (8.4?11.5)?g/L, (7.7?5.2)?g/L, (9.1?6.3)?g/L and (2.5?1.8)?g/L〕, and the elevation was increased with the progress of LIC. The sensitivity of 4 tumor markers was related with the stages of LIC. Parallel combined testing methods increased the diagnostic sensitivity to 83.5%, and serial combined testing increased the diagnostic specificity to 88.7 %. The levels of serum tumor markers declined significantly after operation. The rate of recurrence or metastasis was 73.3% and 85.2% respectively in cases that the serum tumor markers were not decreased to normal level and reelevated after the operation. Conclusions Serum tumor markers show certain values in the diagnosis and the follow-up for LIC in the aged patients and can be used to monitor tumor recurrence and metastasis. The combined assay of tumor markers is helpful in the early diagnosis of LIC and increases the sensitivity and specificity in diagnosing LIC.

Objective:To summarize and analyze the clinical data of Chinese patients with colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy, and clarify the phenotypic and genetic characteristics of Chinese patients.Methods:Medical history of patients with CSF1R-related leukoencephalopathy diagnosed from April 1, 2018 to January 31, 2021 in the department of neurology of 22 hospitals in China was collected, and scores of Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA), magnetic resonance severity scale were evaluated. Group comparison was performed between male and female patients.Results:A total of 62 patients were included, and the male-female ratio was 1∶1.95. The age of onset was (40.35±8.42) years. Cognitive impairment (82.3%, 51/62) and motor symptoms (77.4%,48/62) were the most common symptoms. The MMSE and MoCA scores were 18.79±7.16 and 13.96±7.23, respectively, and the scores of two scales in male patients (22.06±5.31 and 18.08±5.60) were significantly higher than those in females (15.53±7.41 , t=2.954, P=0.006; 10.15±6.26, t=3.328 , P=0.003). The most common radiographic feature was bilateral asymmetric white matter changes (100.0%), and the magnetic resonance imaging severity scale score was 27.42±11.40, while the white matter lesion score of females (22.94±8.39) was significantly higher than that of males (17.62±8.74 , t=-2.221, P<0.05). A total of 36 CSF1R gene mutations were found in this study, among which c.2381T>C/p.I794T was the hotspot mutation that carried by 17.9% (10/56) of the probands. Conclusions:The core phenotypic characteristics of CSF1R-related leukoencephalopathy in China are progressive motor and cognitive impairment, with bilateral asymmetrical white matter changes. In addition, there exist gender differences clinically, with severer cognitive impairment and imaging changes in female patients. Thirty-six CSF1R gene mutations were found in this study, and c.2381T>C/p. I794T was the hotspot mutation.