Objective:To evaluate radiography,CT,MRI,and DSA in the diagnosis of chondrosarcomas in pelvis.Methods:A retrospective review was conducted of 14 radiographs,14 CT scans,9 MR images and 6 DSA obtained in 14 patients with histologically proved chondrosarcoma.Results:The sites of tumor occurrence were ilium(4 cases),sacrum(3 cases),both ilium and sacrum(6 cases),and ischium(1 case).Mean tumor size at diagnosis was 9.3 cm(range,3～16cm).Of the 14 cases,allmanifested osteolytic lesions associated with cortical destruction on radiography,CT scans and MR images.Intraosseous calcification suggestive of a cartilage tumor was present in 9 cases on radiographs and 14 cases on CT scans.An associated soft-tissue mass was identified in 11 cases on radiographs,14 cases on CT scans and 9 cases on MR images.Ten of 14 CT scans and 8 of 9 MR images were obtained after intravenous administration of contrast material.The tumors demonstrated heterogeneous enhancement on CT scans and MR images.Six cases of DSA showed abundant blood supply and above 2 feeding arteries.The surgery was done 2～3 days after embolism by spongia gelatinosa.Conclusions:Destruction of bone,soft-tissue mass and cartilage calcification are the characteristic imaging features of the chondrosarcoma.Each imaging modality has advantages and disadvantages.CT and MR images can reflect the pathology of the pelvic chondrosarcoma.Correct diagnosis before operation is useful to the surgeons.

The study examined the association between calcified liver metastases and the histopathology of the primary colorectal carcinoma in Chinese. The clinical, pathological and CT data were retrospectively analyzed in 210 patients (mean age: 54.2 years) with liver metastases from colorectal carcinoma. Plain CT scanning and contrast-enhanced scanning were performed in all the patients. For the contrast-enhanced examination, iohexol was injected by using a high pressure syringe at a flow rate of 2.5-3.0 mL/s. The arterial phase lasted approximately 25 s and the portal venous phase about 60 s. All patients had no history of chronic liver diseases and had never received interventional treatments. χ(2)-test was used to analyze the rate of calcification in the liver metastasis from colorectal cancer of different differentiation degrees. Among the 210 cases of liver metastases, 22 patients (10.5%) were found to have calcified liver metastases on CT scan. Two patients with calcified liver metastasis received lumpectomy and developed calcification in recurrent tumors. Another two patients had calcification in newly developed tumor masses. And the calcification in the newly developed masses was similar to that of their primary counterparts in terms of morphology and distribution. On the enhanced CT scan, the tumors exhibited no enhancement during hepatic arterial phase and showed slight rim enhancement during portal venous scan in the 22 cases. The calcification became obscure on contrast-enhanced scans. Histopathologically, the primary tumors were well-differentiated adenocarcinoma in 6 cases, moderately-differentiated adenocarcinoma in 10, poorly-differentiated adenocarcinoma in 4 and mucinous adenocarcinoma in 2 among the 22 cases. No statistical correlation was noted between the incidence of calcified liver metastasis and the pathological subtypes and differentiation degrees of the primary colorectal carcinoma. It was concluded that calcified liver metastases may result from colorectal adenocarcinomata of different differentiation degrees or mucinous adenocarcinomata in Chinese population. There is no correlation between calcification of liver metastases and the pathological subtype of the primary colorectal carcinoma in Chinese, which is different from the findings that calcified metastases were associated with colorectal mucinous adenocarcinoma in other ethnic groups.

Objective To analyze the association of DOG1 protein with gastrointestinal stromal tumors(GIST). Methods Seventy-seven patients diagnosed with GIST between January 2005 and June 2010 were enrolled. The DOG1 expression in GIST was determined using immunohistochemistry.The result was compared with that of CD117 and CD34. Results Of 77 GIST patients, the DOG1 was expressed in 74 (96.10%) patients and CD117 in 70 (90. 9%) patients, with no significant difference between DOG1 and CD117 (P＞0.05). DOG1 expression was not related to the risk stratification of the tumor, site, age and gender (P＞0. 05). Of 7 GIST patients with negative CD117,6 patients were positive for DOG1 expression. Whereas 2 of 3 DOG1 negative patients were positive for CD117 expression. Conclusions DOG1, as a novel marker for GIST,has high sensitivity as CD117. It is a good complementarity in diagnosis of GIST when combine DOG1 with CD117, especially in diagnosis of CD117 negative patients. However, the DOG1 can not be used as an index in eveluating the risk stratification of the GIST.

Objective To determine common molecular markers between endometriosis and ovarian cancer . Methods The specimens from 31 endometriosis patients who underwent laparoscopic excision , 28 other disease patients with normal oarium and 35 ovarian cancer patients who received the ovariectomy were collected. Expressions of transforming growth factor β1 (TGF-β1), cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), estrogen receptor 1α(ER-1α), progesterone receptor (PR), androgen receptor (AR) and aromatase (CYP19) were detected by real-time reverse transcription polymerase chain reaction (RT-PCR). Results Compared with those in normal oarium group, the mRNA levels of TGF-β1, VEGF, ER-1α, AR, CYP19 and COX-2 in endometriosis group were increased by 2.05 fold, 2.20 fold, 3.32 fold, 1 . 45 fold , 3 . 19 fold and 3 . 00 fold , respectively , and the mRNA level of PR was reduced by 69 % ( all P< 0.05), while those in ovarian cancer group were increased by 5.61 fold, 7.61 fold, 7.49 fold, 4.79 fold, 7.76 fold and 5.35 fold, respectively, and the mRNA level of PR was reduced by 95 % (all P< 0.05). Conclusion In endometriosis and ovarian cancer tissues, the expression levels of TGF-β1, COX-2, VEGF, ER-1α, AR and CYP19 are increased, and the expression levels of PR are decreased, which maybe suggest both diseases are potentially relevant.

0.05). The threshold of warm of digit 2 differed remarkably from digit 5 ( P

Objective To investigate changes of markers of prethrombotic state(PTS)with heart failure and to explore their clinical significances.Methods Plasma levels of t-PA、PAI-1、Fg、PT、APTT、ET-1、MPV were measured in 52 patients with heart failure and in 38 normal controls.Results Compared with the healthy control group,patients with heart failure had significant increase of plasma PAI-1、Fg and ET-1level.Conclusions PTS is present in heart failure,especially in those with more severe Nyha class.

The effect of 5.8 ////mol L-1 propafeone on 0 phase depolarization of action potential were studed in meonatal and adult canine Purkinje fibres. Results showed: 1. in both groups, propafenone caused a reduction if APA and a decrease of Vmax; and the neonatal fibres were less sensitive to propafenone; 2. the inhibition of Vmax by propafenone showed frequency-dependent manner in both groups; and with theincrease of frequencies, the extent to which Vmax was inhibited became similiar in both groups. This sudy suggests that neonates were less sensitive to propafenone, but at higher frequencies neonates showed similiar responses as adults.

The MRI appearances of 7 adult patients with pathologically proven intracranial primitive neuroectodermal tumors (PNET) were retrospectively analyzed. The MRI features were compared with findings in pathology and surgery. In this group, the tumor masses were most commonly found in the semisphere of cerebrum and in the vermis of cerebellum. They were relatively large and 4 were in lobulated shape. All of them had well-defined margins. MR images showed the tumors to be mildly or obviously hypointense on T1-weighted images and hyperintense on T2-weighted images. Most masses had heterogeneous appearances with some cystic and necrotic areas. Intratumoral haemorrhage and focal calcification were occasionally seen. Mostly, there was no or only mild surrounding edema. Marked inhomogeneous contrast enhancement on MRI was seen in 6 cases except one. Two patients with multiple intracranial metastases were revealed on MR images. In this series, there was good correlation between MRI features and findings in pathology and surgery. These results showed that certain MRI features might suggest the diagnosis of intracranial PNET in adults. MRI is an effective technique to detect these tumors and is helpful to treatment planning and follow-up.
Brain Neoplasms/*diagnosis ; Brain Neoplasms/*pathology ; *Magnetic Resonance Imaging ; Neuroectodermal Tumors, Primitive/*diagnosis ; Neuroectodermal Tumors, Primitive/*pathology ; Retrospective Studies

Objective To explore the effect of antinuclear antibody ( ANA+dsDNA),extractable nuclear antigen (ENA) and antineutrophil cytoplasmic antibody (ANCA) on the clinical manifestation and cerebrospinal fluid characteristics of neuromyelitis optica (NMO).Methods All 41 patients with NMO in PUMC hospital from 1985 to 2009 were retrospectively reviewed.All patients underwent examination of serum ANA+dsDNA,ENA and ANCA.Fourteen positive-autoantibody patients were compared with 27negative-autoantibody patients in gender,onset age,duration,relapse ratio,first demyelination event,the extent of optic neuritis and myelitis,EDSS,CSF protein,WBC,Oligoclonal band, 24 hours IgG index and myelin basic protein.Results The 14 NMO patients (34.1%) had positive non-organ-specific antibodies.NMO patients who had negative autoantibodies were compared with NMO patients with positive autoantibodies with significantly higher EDSS (the EDSS score were 4.5 and 2.5 respectively,U=92.5,P=0.008),more complete damage of spinal cord (3/14 vs 0/27, x2=6.736, P=0.0095) and tended to have higher visual Function Scale in remitting phase.There was no significant difference on the gender,onset age,duration,relapse ratio,first demyelination event.The positive-autoantibody patients had higher CSF WBC (2.0 vs 0,U=68.0,P=0.007) and tended to have lower 24 hours IgG index (-8.663 vs 0.163,U=30.0,P=0.053).There was no significant difference in CSF protein,MBP and OB.Conclusion NMO patients with positive autoantibodies have more severe intrathecal autoimmune inflammatory and disability,so they might need more intensive treatment.

Objective To explore the expression of glucose-regulated protein (Grp) 78 in ovarian cancer tissues and its clinical significance.Methods The expression of Grp78 in 60 cases of ovarian cancer tissue,15 cases of ovarian borderline tumor tissue,10 cases of normal ovarian tissue,10 cases of ovarian cyst tissue,was detected by immunohistochemistry,and analyzed the relationship between its expression and clinicopathological features of ovarian cancer.Results The expression of Grp78 in ovarian borderline tumor and ovarian cancer tissue was significantly higher than that in normal ovarian and ovarian cyst tissue[7/15 and 68.3％ (41/60) vs.1/10 and 1/10] (P ＜0.05).The expression of Grp78 was positively correlated with clinicopathological staging and lymphatic metastasis of ovarian cancer (P ＜ 0.05),negatively correlated with histological differentiation (P ＜ 0.05).No correlation with age and ascites (P ＞ 0.05).Conclusions The levels of Grp78 are elevated in ovarian cancer specimens; high expression of Grp78 maybe participate in the occurrence,development,and prognosis of ovarian cancer.Increased expression of Grp78 might be a useful marker for predicting the carcinogenesis and progression of ovarian cancer.