The Syndrome of yin -deficiency was made by thyroid hormone with reserpine in Kunming mice. Oyster complete nutritional tablet was used to treat the syndrome of yin -deficiency in mice. The results showed that a series of syndrome of the yin -deficiency were improved and animal mortality was cut down patently. The degree of histopathologic damage in cells of liver,kidney,spleen,intestine was reduced and histochemical observation suggested that the contents of RNA and glycogen in liver cell were raised significantly. Abnormal activity of enzyme was improved. The tablet showed a benefit effects on protecting liver, kidney,spleen and intestine to a certain extent.