Objective To investigate the clinical efficacy of abdominal acupuncture plus pricking bloodletting in treating diabetes-associated herpes zoster. Methods One hundred diabetes patients were randomly allocated to treatment and control groups, 50 cases each. Both groups took oral hypoglycemics and acyclovir. In addition, the treatment group received abdominal acupuncture plus pricking bloodletting and control group, electroacupuncture plus local surround needling. The time for blister disappearance, the time for pain relief and the time for scabbing were observed in the two groups before and after treatment. The clinical therapeutic effects were compared between the two groups. Results The total efficacy rate was 92.0%in the treatment group and 86.0%in the control group;there were statistically significant differences between the two groups (P<0.05). There were statistically significant differences in the time for blister disappearance, the time for pain relief and the time for scabbing between the two groups (P<0.01, P<0.05). Conclusion Abdominal acupuncture plus pricking bloodletting is an effective way to treat diabetes-associated herpes zoster.

One new quinoline alkaloid and seven known bisabolane sesquiterpenes: 2-(2'-methyl-1'-propenyl)-4, 6-dimethyl-7-hydroxyquinoline(1), 2, 5-dihydroxybisabola-3, 10-diene(2), 4, 5-dihydroxybisabola-2, 10-diene(3), turmeronol A(4), bisacurone(5), bisacurone A(6), bisacurone B(7), bisacurone C(8), as well as dehydrozingerone(9) and zingerone(10) were isolated from the root tuber of Curcuma longa. Their structures were identified by spectral evidence. Compound 1 is a new compound, compounds 6-8 were isolated from this plant for the first time and compounds 9-10 from Curcuma for the first time.

Objective Neurological diseases are closely associated with the apoptosis of neuronal cells .This article aims to study the inhibitory effect of taurine on the apoptosis of hippocampal neurons by activating Caspase 9 as well as its protective effect on the nervous system and its mechanisms . Methods Mouse hippocampal neuronal cells were randomly divided into four groups:control, injury and apoptosis, low-dose taurine protection, and high-dose taurine protection.The proliferation of the neuronalcells was observed, their apoptosis examined by MTT colorimetric assay, and the expression of Caspase 9 in different groups detected by immunofluorescence and Western blot. Results The injury and apoptosis group showed a poor proliferation of the hippocampal neuronal cells and decreased cell viability (A=0.102 ±0.025), significantly lower than the control group (relative A=0.643 ± 0.013), the low-dose taurine group (relative A=0.504 ±0.072), and the high-dose taurine group (relative A=0.452 ±0.029) ( all P<0 .05 ) .Immunofluorescence assay revealed significantly increased Caspase 9 activation in the injury and apoptosis group (A=61386.8 ±10083.6) compared with the control (A=4502.2 ±2518.1), the low-dose taurine (A=20077.4 ±4187.5), and the high-dose taurine group (A=13976.2 ±7044.1) (all P<0.05).Western blot showed a remarkably higher expression of Caspase 9 in in the injury and apoptosis group (A=1.23) than in the control (relative A=0.17), the low-dose taurine (A=0.21), and the high-dose taurine group (A=0.19) (all P<0.05). Conclusion Taurine can protect neuronal cells by inhibi-ting Caspase 9 activation.

ObjectiveTo study the diagnostic value of double balloon endoscopy (DBE) for gastrointestinal disease.MethodsClinical data of 53 patients with suspected intermediate gastrointestinal diseases who underwent DBE procedures were retrospectively analyzed for detection rate,complications and the incidence of adverse reactions.ResultsAll of 53 patients underwent successful DBE,Procedures were performed via mouth ( n =26),anus ( n =9 ) and the combined routes ( n =18 ).And definite diagnosis was made in 46 cases (86.79％),including upper gastrointestinal (above ligament of Treitz) disease in 3 cases (5.66％),intermediate gastrointestinal disease in 41 cases (77.36％ ) and lower gastrointestinal disease in 2 cases (3.77％).All 53 patients were tolerant to the operation and anesthesia.No severe complications like bleeding,perforation,intestinal torsion,mesenteric tear,pancreatitis or anesthetic accident occured.Several patients showed abdominal flatulence,transient abdominal pain.Some patients in oral route reported slight throat discomfort or slight nasal bleeding.Incarceration occurred in 1 case due to friction of endotracheal intubation and the silicone tube,which was released after deflation and removed out.2 patients showed mild diarrhea with low fever,and the symptoms were self-healing without special treatment in 48 h.ConclusionDBE is of high diagnostic value for gastrointestinal diseases with a high safety.

Objective To understand the present situation of Successful Aging (SA) and its Constitution Types of Traditional Chinese Medicine (CTTCM) in the elderly,exploring on the correlation between SA and CTTCM. Methods Totally 198 old adults from community service center were investigated with Chinese-version Successful aging Inventory (C-SAI) and TCM physique type scale. Results The mean score of SA was(56.90±10.01), the physical types of the elderly are mostly biased. The results of one-way variance analysis of Constitution Types of Traditional Chinese Medicine showed that there were differences in the SAI scores of old people with different physique types (F=21.180, P<0.05). Multiple linear regression analysis showed SA scores were statistically significant in terms of educational level, living styles, dietary habits, sleep quality and participation in social activities (t=-4.969-4.257, P<0.05). Conclusions The SA in our study was at a moderate level, the constitution types of the elderly are mainly biased. The Constitution Types of Traditional Chinese Medicine could influence the old adults′ SA. By providing individualized Chinese medicine intervention for the elderly to correct biased physique, and improve the level of successful aging in future.

Objective To investigate the clinical efficacy of endoscopic variceal ligation (EVL) in the treatment of type 1 gastroesophageal varices (GOV1).Methods From July 2016 to May 2017,at the First Affiliated Hospital of Anhui Medical University,NO.2 People's Hospital of Fuyang City and the Sixth People's Hospital of Shenyang,the efficacy of EVL in the treatment of patients with GOV1 were retrospectively analyzed.The number of ligation rings,emergency (bleeding within 24 hours) hemostasis,successful hemostasis,early rebleeding (from 72 hours to six weeks after operation),delayed rebleeding (at six weeks after operation) and disappearance of gastroesophageal varices were observed.Patients were followed up for six to 16 months and postoperative complications of EVL were evaluated.Results There were 61 patients with GOV1 (40 males and 21 females),and the mean age was (50.9±10.9) years.The number of ligation during EVL operation was one to six (mean 3.8 ± 1.9).Seven patients with active bleeding were all successfully achieved emergency hemostasis.One case had rebleeding in 72 hours after operation,and the hemostatic rate was 98.3 ％ (60/61).The early rebleeding rate was 11.5 ％ (7/61),the delayed rebleeding rate was 4.9％ (3/61),and the total rebleeding rate was 16.4％ (10/61).The disappearance rate of gastroesophageal varices was 85.2％ (52/61).The complication rate was 21.3％ (13/61).No post-ligation ulcer bleeding,spontaneous bacterial peritonitis and perforation were observed in all patients.Conclusions EVL can effectively control the acute hemmorrhage of GOV1 type gastric varices.The postoperative rebleeding rate and complication rate are low.However,the disappearance rate of varices is high.

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant degenerative disease. The main clinical manifestation of SCA2 is progressive cerebellar syndrome, but a wide range of extracerebellar and non-motor symptoms can be observed clinically. The non-motor symptoms and extra-cerebellar signs in SCA2 patients are reviewed to provide a better understanding in cognition, diagnosis and treatment of the disease.

This article explains the concept of completion ability, summarizes the measurement tools of nursing students' completion ability and the status of completion ability, and analyzes the influencing factors of nursing students' completion ability from the levels of personal, school, and clinical practice, aiming to explore scientific and effective training models and intervention measures to provide reference for future research.

Objective:To explore the mediating effect of adversity quotient between transition shock and work readiness among newly graduated nurses.Methods:This is a cross-sectional study. From May to June 2021, a total of 242 newly graduated nurses from three ClassⅢ Grade A hospitals in Shandong Province were selected as the research objects by the convenient sampling method. The general situation questionnaire, Transition Shock Scale of Newly Graduated Nurses (TSS-NGN) , The Adversity Response Profile (ARP) and Work Readiness Scale for Graduate Nurses (WRS-GN) were used to survey. Pearson correlation analysis was used to test the correlation between transition shock, adversity quotient and work readiness AMOS 23.0 was used to establish the structural equation model. A total of 242 nurses were investigated in this study. 228 valid questionnaires were collected, and the effective recovery rate was 94.21%.Results:Among 228 newly graduated nurses, the total scores of work readiness, transition shock and adversity quotient were respectively (279.04±47.73) , (81.43±22.22) and (132.39±15.00) . Transition shock was negatively correlated with adversity quotient and work readiness ( r=-0.307, -0.291; P<0.01) , and adversity quotient was positively correlated with work readiness ( r=0.339, P<0.01) . The results of structural equation modeling showed that adversity quotient partially mediated between transition shock and work readiness (β=-0.243, P<0.01) , and the mediating effect accounted for 38.76% of the total effect. Conclusions:The work readiness of newly graduated nurses is at the upper middle level. Clinical nursing managers should pay attention to cultivating the adversity quotient of newly graduated nurses, so as to reduce the negative effect of transition shock on their work readiness, in order to realize a good transition from school to clinical nursing work.

Fathers play an important role in supporting maternal breastfeeding. Father's self-efficacy in supporting breastfeeding can predict the outcome of breastfeeding. This article reviews the concept, evaluation tools, roles, status, influencing factors, and intervention measures of self-efficacy in father's support for breastfeeding, so as to provide suggestions for further promoting the formation of breastfeeding intervention plans, thereby improving marital relationships, and promoting infant health.