Objective To investigate the early post-operative nutritional support for kidney transplant recipients.Methods Totally 67 patients who received early post-operative nutrition supports were randomly divided into three groups:group A (n = 24,relatively high nitrogen intake),group B (n = 25,intermediate nitrogen intake) and group C (n = 18,relatively low nitrogen intake).Two weeks after operation,albumin,hemoglobin,the nutrition indieators,serum lipids,and renal function 1 day before operation and 2 weeks after operation were evaluated. Results Body weight was significantly different among three groups;the nitrogen balance in group A was significantly better than those in groups B and C (P ＜0.05);albumin and hemoglobin were not significantly different between group A and group B (P ＞ 0.05),but were significantly higher than those in group C (P ＜ 0.05).The renal function in group C was significantly better than those in group A and group B (P ＜ 0.05).The triglyceride level was not significantly different among three groups,while the cholesterol level in group A was significantly higher than those in group B and group C (P ＜ 0.05),but not between group B and group C.Conclusion Proper nitrogen intake in early post-operative nutrition support can improve the recovery of renal function and nutritional status in kidney transplant recipients.

Objective To investigate the correlation between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district .Methods The polymorphisms of Fas-670 gene were detected by polymerase chain reaction-restric-tion fragment length polymorphisms assay (PCR-RFLP) in 232 female breast cancer patients ,χ2 test was applied to assess the asso-ciation between the polymorphisms of Fas-670 gene and breast cancer clinic pathologic index .Results In 232 breast cancer pa-tients ,the frequency of Fas-670 homozygous wild type(AA) ,heterozygous type(AG) ,homozygous mutant type(GG) were 39 .7%(92/232) ,48 .7% (113/232) ,11 .6% (27/232) respectively .It was no statistical significance between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district(P>0 .05) .Conclusion The polymorphisms of Fas-670 gene is not associated with clinic pathologic index of breast cancer in Qinghai district .

Objective To study the prevalence of thrombocytosis in patients with non-small-cell lung cancer (NSCLC) and its correlation with clinicopathological features.Methods 156 patients with advanced NSCLC were retrospectively analyzed.The platelets degree between the groups with different sex,age,smoking,histological type of advanced NSCLC was compared and analyzed statistically.The relationship between the platelet count and chemotherapy effects was analyzed.Single analysis and Cox regression analysis were used for TTP and OS.Results Compared with the healthy persons,Plt significantly elevated in group with advanced NSCLC (36.5 ％,57/156 vs 5.0 ％,5/100) (P ＜ 0.01),and thrombocytosis group responded poorly to chemotherapy (22.8 ％,13/57 vs 39.4 ％,39/99) (P ＜ 0.05).The TTP (3.0 months vs 5.2 months) and OS (11.2 months vs 14.2 months) of Plt elevated group were significantly shorter than those of normal group.Conclusion Thrombocytosis is closely related to progress and metastasis of advanced NSCLC.Platelet count can be used as an assistant index in the prognosis judgment of patients with advanced NSCLC.

Objective To investigate the relationship between the area of corpus callosum and neurodevelopmental outcomes in very preterm infants.Methods Brain magnetic resonance (MR) images of 106 term infants with gestational age 40 weeks were obtained,which were collected in 24h after birth.Brain MR images of 130 very low birth weight (VLBW) neonates at 40-week gestational age equivalent were successfully obtained.A total of 228 eligible MR images of them were chosen,and divided into the full-term infant group (100 cases) and the premature infant group (128 cases).The whole and sub-regional corpus callosum areas were calculated.The 20-neuromotor examinations were performed at 3 months of corrected gestational age.Results The whole corpus callosum,anterior mid-body,posterior mid-body,isthmus and splenium area in very premature infant group were significantly smaller than those in full-term infant group (P ＜ 0.05),but the differences in genu and rostral body area between two groups was not statistically significant (P ＞ 0.05).The genu area in the abnormal nervimotion group was significantly smaller than that in the normal nervimotion group (P ＜ 0.05),but the differences in the whole corpus callosum,anterior mid-body,posterior mid-body,isthmus,and spleniuvm area between two groups were not statistically significant (P ＞ 0.05).Conclusions The development of very premature infant corpus callosum is affected by prematurity,especially posterior end of corpus callosum.Adverse neurodevelopmental outcomes at 3 months of corrected gestational age may be associated with decreased genu area of corpus callosum in very preterm infants.

OBJECTIVE To investigate the etiological factors,diagnosis and therapy of postmenopausal pyometra.METHODS The 8 cases of postmenopausal pyometra who hospitalized at China-Japan Union Hospital of Jilin University were retrospectively analyzed.RESULTS Postmenopausal pyometra was related with senile vaginitis,endometritis,not taking out of IUD after menopause promptly and endometrial cancer.There were 3 patients complicated with uterine perforation and 1 patient complicated with septic shock.4 patients had intrauterine dropsy with ultrasonic inspection.5 patients were cured with draining in cavitary uteri,and 3 patients were cured with operation.CONCLUSIONS The courses of postmenopausal pyometra are slow moving,with no evident clinical symptoms,which is easy to be misdiagnoed.Some have severe complications.We should prevent the disease aimed at carly diagnosis and therapy.

The clinical values of acetoacetate ( AcAA ) and β hydroxybutyrate ( βHBA ) determination in classification of type 1 and2 diabetes were explored. 102 normal control subjects,33 cases of type 1 diabetes, and 104cases of type 2 diabetes were enrolled. Serum AcAA, βHBA, fasting plasma glucose ( FPG), C-peptide, and insulin levels were measured. The results showed that serum AcAA, βHBA, total ketone tody (TKB) levels in the diabetic groups were significantly higher than those of the normal group( P＜0. 01 ). AcAA, βHBA, TKB levels in type 1diabetes were higher as compared with those of type 2 diabetes( P＜0.01 ). The AcAA, βHBA, and TKB levels were negatively related with C-peptide and insulin in diabetic patients( P＜0. 01 ). All the type 1 diabetic patient were found to have TKB and lower C-peptide levels. TKB positive and lower C-peptide in type 2 diabetes were found in 47% and 26% respectively. Receiver operating characteristic (ROC) curve suggested that the area under the ROC curve of type 1 and type 2 diabetes was 0.926. The optimal operating point of the total ketone body was 0. 532 mmol/L with higher sensitivity and specificity. Enzymatic determination of acetoacetate and β hydroxybutyrate seems to have important clinical values for classification of type 1 and 2 diabetes.

Cochlear Implantation ; Cochlear Implants ; Guidelines as Topic

Objective To evaluate the diagnostic value of the level of plasma D-dimer, lipoproteins and carcino-embry-onic antigen(CEA) in gastrointestinal cancer.Methods The plasma D-dimer ,lipoproteins,CEA and clinicopathological data of 139 gastrointestinal cancer patients and 155 normal controls were collected and analyzed .Lipoproteins included high-density lipoprotein(HDL),low-density lipoprotein(LDL) and lipoprotein a[LP(a)].SPSS 13.0 statistical software was used to analyze the sensitivity and specificity of each examination method and to find the appropriate combination .Results The plasma D-dimer,LDL,LP( a) and CEA levels were distinctly higher in patients than those in normal controls ( P<0.001).HDL levels were significantly lower in patients than those in normal controls (P<0.001).The cutoff of D-dimer was 0.495 μg/ml , the sensitivity of D-dimer was 62.6%,and the specificity was 86.5%.The cutoff of HDL was 1.025 mmol/L, the sensitivity was 72.7%,and the specificity was 85.2%.The cutoff of LDL was 3.375 mmol/L, the sensitivity was 54%,and the specificity was 82.6%.The cutoff of LP(a) was 27.3 mg/dl, the sensitivity was 58.3%,and the speci-ficity was 87.1%.The cutoff of CEA was 2.14 ng/ml, the sensitivity was 59.7%,and the specificity was 76.8%.The sensitivity and specificity of HDL +CEA were 77.7%and 88.4%, respectively.The sensitivity and specificity of HDL +D-dimer were 70.5% and 96.1%, respectively.The sensitivity of HDL +LP(a) was 76.3%,and the specificity was 93.5%.The sensitivity of D-dimer +HDL+LP(a) was 84.2%,and the specificity was 92.3%.The sensitivity of D-dimer +HDL+CEA was 87.1%, and the specificity was 85.8%.The sensitivity and specificity of HDL +LP(a) +CEA were 85.6%and 92.3%, respectively.The sensitivity of D-dimer +HDL+CEA +LP(a) was 89.9%while the specificity was 92.3%.Conclusions Plasma D-dimer and lipoproteins can serve as tumor markers in gastrointestinal cancer .Combined detection has higher sensitivity and specificity .

AIM: The purpose of this study was to observe the morphological features of neuroendocrine cells(NECs),their proliferation and apoptosis in ovarian epithelial tumors,and to discuss their biological and clinical significance.METHODS: 79 specimens of ovarian epithelial tumor samples were collected,of them 20 benign,18 boderline,41 milignant tumors,and 22 normal ovaries were investigated immunohistochemically.Chromogranin A was used to detect NECs and their proliferation and apoptosis were examined by double-label staining of chromogranin A and Ki67 or TUNEL.RESULTS: The positive rate of CgA,distribution and staining intensity in ovarian epithelial tumors were higher than those in normal ovary.NECs showed various shapes with neuronoid protuberances stretching to the neighboring cells or basement membrane.Occasionally,they might touch together.No TUNEL positive coexpression in all NECs was observed by double-label staining,but some NECs were coexpressed with Ki67.CONCLUSION: NECs of ovarian epithelial tumors like cancer cells showed a proliferation,but no apoptosis.Their secretion might promote their neighboring non-NECs to proliferate and prevent them from apoptosis.

Objective: To explore the relationship between gross motor development and perceived motor competence among children aged 7-8 years old. Methods: Random cluster sampling method was used to conduct a test among 162 students aged 7-8(78 boys,84 girls)by using Test of Gross Motor Development Ⅲ(TGMD-3) and 3 and Pictorial Scale of Perceived competence and Social Acceptance for Young Children(PSPC-P). Results: There were no statistical significance of perceived motor competence in different genders,and ages among children(t=-0.82, -0.58, P>0.05). Gross motor development differed significantly in different age groups (t=-4.79, P<0.01). Eight-year-old group(63.10±5.70) scored higher than 7-year-old group(57.96±7.76).There exists clear association between gross motor scores and perceived motor competence (r=0.29, P＜0.01), as well as locomotor development and manipulative development with perceived motor competence (r=0.21, 0.24, P<0.05). Conclusion There are close correlations between gross motor development and perceived motor competence among children aged 7 to 8 years. Manipulative development shows obvious influences on perceived motor competence. No gender differences are found in perceived motor competence.