Objective: To compare sleep condition and mental ac tivity among short sleeper, insomniacs and normal sleeper Method: Subjects were grouped as normal sleeper, short sleeper (according to ICSD cri teria) and insomniacs All of them were measured with MMPI, self-made questionn a ire on emotion at bedtime Psychophysiological arousal and polysomnogram over n i ght were also recorded Results: Sleep latency was longer in sh o rt sleeper than normal The total spent asleep and sleep efficiency of short sl e eper had no different from those of insomniacs The awake time, A/TSA and funct i on of daytime of short sleeper were as good as normal The result of MMPI showe d , short sleeper had lower scores in Hypochondria, Depression, Conversion Hysteri a and Psychasthenia than insomniacs, higher scores in Hypomania than insomniacs or normal control They were also less anxious than insomniacs at bedtime, had s maller correlation coefficient between daytime psychophysiological arousal and s leep condition than insomniacs had Conclusion: Short sleeper h a s longer sleep latency, but quality of their sleep, their personality and emotio n at bedtime are more close to normal sleeper

OBJECTIVETo investigate the loss of heterozygosity (LOH) on chromosomal arms 13q and 14q in nasopharyngeal carcinoma (NPC) using 21 microsatellite polymorphic markers and to study whether there is a correlation between LOH and clinicopathologic parameters and/or Epstein-Barr virus (EBV) infection in NPC.

METHODSSixty cases of NPC were studied using polymerase chain reaction based microsatellite analysis with genescan and genotyping techniques.

RESULTSLOH was detected on 13q in 78% of NPC tumors, high frequency LOH loci (more than 30%) clustered to 13q12.3-q14.3 and 13q32. On chromosome 14q, LOH was detected in 80% of NPC tumors; high frequency LOH loci clustered to 14q11-q13, 14q21-q24 and 14q32. High frequency LOH at 13q31-q32 correlated with a lower level of EBV infection; LOH on chromosome 14q was closely associated with poor differentiation of NPC tumor cells.

CONCLUSIONOur results suggest that in NPC, LOH on chromosome 13q and 14q are common genetic events, and putative tumor suppressor genes (TSG) residing in these regions may be involved in tumorigenesis.

Adult ; Aged ; Chromosomes, Human, Pair 13 ; genetics ; Chromosomes, Human, Pair 14 ; genetics ; DNA, Neoplasm ; genetics ; Female ; Gene Frequency ; Humans ; Loss of Heterozygosity ; Male ; Microsatellite Repeats ; Middle Aged ; Nasopharyngeal Neoplasms ; genetics ; pathology ; Statistics as Topic