To discuss the significant application for the membrane science and technology in the development of pharmaceutical industry of Chinese materia medica(CMM) in such aspects as obtaination of integrated effctive substances,transformation of traditional technology,reduction of power consumption, product safety,sewage treatment,and technological innovation.To analyze the major restrictions on the industrialization of CMM's membrane science and propose the corresponding measures.Currently,the development of macromolecule science and technology and the implementation of environmental-friendly strategy have advanced the technology of membrane to a new stage and thus offer the insurance to the integration of extraction,separation,concentration,and purification in traditional pharmaceutical production of CMM.Meanwhile,the technolgy of membrane separation has been widely used in the separation,concentration, and purification of macromolecule,which bears similar characteristics with traditional CMM.It is also a proof that the technology of membrane will improve the efficency of traditional CMM production when it is used in the pharmaceutical industry of CMM.

Compound composition of several natural products including plants,animals,and minerals.In the different needs of Chinese medicine research and application,different extraction and separation methods have been chosen,however,these technologies lacked of scientific and reasonable evaluation criteria because most of these technologies stem from other disciplines,which is the main reason for limited application of the method in Chinese medicine.So the key scientific issue is to establish the quality evaluation system of extraction and separation technology in line with the modern medicine.This article aims to establish the scientific principles of evaluation system for extraction and isolation of Chinese herbal compound.

Objective To establish the quality standard for Ulter Zhuhuang gel.Methods Indirubin,cholic acid and borneol were identified by TLC.The content of indirubin and cholic acid was determined by HPLC.Result The TLC sports developed was fairly clear.The HPLC method showed that the average recovery of indirubin and cholic acid was 100.3% with RSD=2.1% and 98.9% with RSD=1.8% respectively.Conclusion The method is convenient and accurate.It can be used for the quality control of Ulter Zhuhuang gel.

Objective To investigate chitosan flocculating and other pretreatments of Huoxue Tongluo extract and their effects on the membrane flux and fouling degree of membrane. Methods Based on the index related to the total sinomenine reserved in liquid and fouling degree of membrane, compared to other pretreatments, discuss the function of chitosan used as flocculation and the effect on membrane separation by orthogonal test. Results The reservation of the total sinomenine was best by means of chitosan flocculation and the smallest fouling degree of membrane was it too, compared with other pretreatments as decompress filtration, high-speed-centrifugation, low-speed-centrifugation and decolored by active carbon. Conclusion Chitosan flocculating is the best pretreatment method of Huoxue Tongluo extract, and the suggested operation condition is that the Huoxue Tongluo extract’s temperature is 50 ℃, pH=5 and add 1% chitosan 30 mL/L.

AIM:To explore the effect on stability of hyperforin with different medicinal herbs and the changes of hyperforin content in herb combinations with Hypericum perforatum L.(HP).METHODS:Several common antidepressant medicinal herbs were selected separately to match with HP.The herbal samples consisted of HP group,HP with Curcuma wenyujin Y.H.Chen et C.Ling group,HP with Curcuma longa.L.group,HP with Epimedium brevicornum Maxim group and HP with Wuling powder(WY)group.The contents of hyperforin with each group were determined by reverse phase HPLC.RESULTS:The rates of extraction and retention of hyperforin in HP with Curcuma wenyujin Y.H.Chen et C.Ling group and HP with Curcuma longa.L.group were significantly lower than that of HP group.There were no obvious differences in the extraction rates of the HP group,HP with Epimedium brevicornum Maxim group and HP with WY group.The retention rate of hyperforin in HP group with WY powder was higher than that of HP group.The retention rate of hyperforin in HP with Curcuma wenyujin Y.H.Chen et C.Ling group,was lower than that of HP group.CONCLUSION:The results show that compatibility of HP with traditional Chinese medicine have effects on the stability of active herbal component.

This review focuses on the current situation of traditional Chinese medicine culture propaganda in the field of basic public health and summarizes that traditional Chinese medicine culture propaganda in this field adopts health lectures, household surveys, books, videos, billboards, village radio and other forms. The existing single forms of publicity lead to poor awareness of traditional Chinese medicine knowledge and nonsufficient service in the treatment with traditional Chinese medicine. It is suggested to build and improve the health publicity system, mobilize the residents' senses in an all-round way, and promote nationwide body health.

Objective To investigate the effect of different transdermal enhancers on percutaneous absorption of ephedrine in Compound Herba Ephedrae Adhesive Plaster.Methods Using modified Franz diffusion cell,the ephedrine content was determined to investigate the effect of different transdermal enhancers in promoting percutaneous absorption.Results Azone or azone used together with other transderml enhancers had a better effect in promoting percutaneous absorption,indicating that azone was the leading transderml enhancers for ephedrine.The mixed transdermal enhancer of azone and propylene glycol was the most effective combination and the rate constant of percutaneous absorption is 94.280 ?g?cm-2?h-1.Conclusion The mixture of azone and propylene glycol can enthance the percutaneous absorption of ephedrine and can be used as the transdermal enhancers for this compound plaster.

Objective To establish the quality control standard of Pinellia Heart-Sedating Granules. Methods TLC methods for identifition of Radix Pinellia and Radix Scutellariae were established. A simple HPLC was established for the determination of Berberine hydrochloride. Results The spots on TLC plates were clear without interference in the blank reference. The liner range of Berberine hydrochloride was 0.009375～0.3 ?g,r =0.9 999. The average recovery of Berberine hydrochloride was 101.46% and RSD was 2.88%. Conclusion The method is simple, accruate, reproducible and can be used as the quality control method for Pinellia Heart-Sedating Granules.

AIM: To discuss the fouling mechanism of 0.2 ?m Al_2O_3 ceramic membrane in the microfiltation of extraction of Qijudihuang Pills, and obtain the effective cleaning procotrol. METHODS: The extract of Qijudihuang Pills microfiltered and the distributions of filtration resistance were studied according to the Darcy-Poiseuille principle. The characteristic of the surface and section of the polluted membrane were analysed by SEM also. RESULTS: ① For the main body, the filtration resistance was mainly decided by the deposit resistance, the membrane itself and the concentration polarization resistance were less important, and the pore blocking resistance was minimum. Moreover, this result was proved by the analysis of SEM. ② The effective four-step cleaning procotrol, which could almost recover original membrane flux, was achieved by three cleaner, including ultrasound, NaOH solution and HCl solution. CONCLUSION: Based on the different fouling mechanism,the appropriate cleaning procotrol can be obtained. This provides great significance for the application of the industrialized manufacture.

The aim of the study is to investigate the effects of concentration, intestinal segments, pH, inhibitors of proteins (P-gp), Na(+)-dependent glucose transporter (SGLT1) on the intestinal absorption of berberine, and to compare intestinal absorption of berberine in combinations. With phenol red as the indicator, in situ single pass intestinal perfusion (SPIP) model was used and intestinal absorption of pure berberine at concentrations of 36.70, 46.17 and 92.33 microg x mL(-1), simulated system of HLJDT (mixture of berberine, baicalin and geniposide), HLJDT with the concentration of berberine 92.33 microg x mL(-1) in perfusion solution of different intestinal segments (duodenum, jejunum, ileum, and colon) were determined by HPLC in combination with diode array detection (DAD). The results indicated that Ka values ofberberine at different concentrations had little significant difference among that obtained after perfusing via duodenum, jejunum, ileum and colon indicating that the absorption of berberine was mainly the passive diffusion. It was also suggested that SGLT1 and P-gp might exert some effects on the absorption of berberine. Ka and Peff values of berberine in a mixture of pure compounds and HLJDT for different intestine segments of rat showed an increasing tendency and was significantly different (P < 0.05) indicating that berberine in a mixture of pure compounds and HLJDT was assimilated better in small intestine. These results indicate that the intestinal absorption of berberine may be affected by compatibility of compounds. Additionally, berberine has wide absorption window and better absorption in colon.