Transforming growth factor β1 (TGF-β1) is a member of cytokine superfamily.Recent studies reveal that the abnormality of TGF-β1 and its receptors is strongly related to genesis,progression and prognosis of lung cancer.It plays an important role in early diagnosis,stage and assessment of treatment and prognosis of lung cancer.

[Objective]To assess whether calcitonin exerts an chondroprotective action in unstable knees which induce experimental osteoarthritis and its effect to MMP-1.[Method]Twenty 6-month New Zealand rabbits underwent anterior cruciate ligament transaction(ACLT) and were divided into two groups (ACLT group and ACLT+CT group) randomly after transaction on day 7 postsurgery. ACLT+CT group rabbits received a daily subcutaneous injection of salmon calcitonin at a dose of 5 IU per kg of body weight for six weeks.ACLT group were treated with the normal saline at the same dose. All animals were sacrificed 7 weeks postsurgery. The articular cartilage degeneration of medial femoral condyle was evaluated at mascroscopically and microscopically. The mRNA expression and tissue level of MMP 1 was detected by RT-PCR and immunohistochemistry.[Result]Cartilage degradation in ACLT group was significantly more severe than that in ACLT+CT group both in microscopic grading scale and in Mankin's grading scale (P

General practitioners from community health service institutions in Shijingshan,Mentougou,Haidian,Chaoyang,Fengtai and Dongcheng Districts of Beijing were selected to take the examination of chronic wounds management.Questionnaire survey was also performed on the status of community chronic wounds management,medical service motivation,influencing factors and their demand for training.Among 204 general practitioners,55 (27.0％) had mastered basic knowledge,98 (48.0％) passed the examination and 51 (25.0％) failed.The results showed that 179 (87.7％) had changing dressing service,36.8％ offered out-patient consulting service,17.6％ performed surgical debridement,only 10 (4.9％) provided home chronic wounds care service and 2 (0.9％) of them carried out long-term follow-up.According to the motivation survey,all the practitioners expressed the willingness to help the patients and win their trust.Most of the practitioners claimed no supporting from their institutions(91.7％) and chronic wounds management was excluded from daily routine.Furthermore,heavy work load(82.8％) and lack of professional knowledge(80.9％)were also considered to be main obstructive factors.The survey showed that the majority of physicians required classroom teaching (90.1％),case analysis (86.8％),operating video (92.6％) and other teaching forms.More low level doctors(97.1％)had the desire to pursue further specialist training than higher level physicians (56.7％).The results of our investigation indicate that general practitioners in community heath service institutions have strong learning motivation for chronic wounds management and systematic training of knowledge and practical skills in this field should be provided.

Health Personnel ; Humans ; Infection Control ; Infectious Disease Transmission, Patient-to-Professional ; Occupational Diseases ; prevention & control

Intraparotid facial nerve schwannoma (IFNS) is a rare benign tumor. The management of IFNS is very challenging because of the lack of appropriate methods for preoperative diagnosis, which is often conducted intraoperatively in most cases. This article reviewed the literature on IFNS recorded in PubMed from 1958 to 2014 and described in detail its clinical manifestations, diagnoses and differential diagnoses, and treatment options. Accurate diagnosis for IFNS mainly depends on intraoperative observation and postoperative histological examination. Preoperative facial nerve function, localization, and adherence, as well as preferences of IFNS patients are important factors to consider in the decision-making process for IFNS management to optimize the outcomes. Surgical resection is usually reserved for patients with facial function of House-Brackmann grade III or worse; otherwise, conservative treatment can be adopted.
Cranial Nerve Neoplasms ; Diagnosis, Differential ; Face ; Facial Nerve ; Humans ; Neurilemmoma ; Postoperative Period ; Retrospective Studies

Humans ; Mycoplasma pneumoniae ; Pneumonia, Mycoplasma ; microbiology

Tocotrienol has showed inhibition effect on a variety of cancer cells. It has different mecha-nisms in different types of cancer cells. Its anticancer effects may be mediated by anti-proliferation,anti-oxida-tion,pro-apoptotic and affecting apoptosis signal pathway. Further study on tocotrienol will provide scientific the-ory for new antitumor drugs and cancer primary prevention.

Objective To explore the cognitive changes of patients with MCI using the Montreal Cognitive Assessment(MOCA) for elderly preliminarily.Methods 85 normal controls (NC),117 subjects with mild cognitive impairment (MCI) and 73 patients with Alzheimer's disease (AD) were assessed with the MOCA.Results There were significant differences among the three groups in all items of MOCA(F=258.66,P＜0.01).Significant differences were observed in almost all the sub-tests between MCI group and NC group or MCI group and AD group(visuopatial F=54.86,P＜0.01;naming F=17.30,P＜0.01;attention F=82.50,P＜0.01;language F=25,88,P＜0.01;abstraction F=15.00 ,P＜0.01;delayed recall F=130.49,P＜0.01;orientation F=176.09,P＜0.01.).The most significant differences were found in delayed recall and orientation among three groups(F=176.09,P＜0.01;F=130.49,P＜0.01.).At 26 cut-point,The results of screening of the MOCA agree with the gold standard of clinical diagnose for the patient with MCI.The agreement rate for observation was 0.93.The agreement rate by chance was 0.61.The Kappa was 0.85.Conclusions The MOCA appropriately define MCI,NC and AD in their cognitive function,it has good discriminant validity.The test of delayed recall and orientation may be more sensitive in the detection of the older people.The MOCA is a useful screening instrument for the patient with MCI.

The relation of methylenetetrahydrofolate(MTHFR)reductase C677T polymorphism with primary hyperuricemia and gouty arthritis was observed in People's Hospital of Shanxi Province.MTHFR reductase C677T pdymorphism in 195 subjects was examined by PCR-restriction fragment length polymorphism.The results showed that MTHFR gene mutation might be a risk factor for primary hyperuricemia.However,C677T polymorphism of the MTHFR gene was not related to the development of gouty arthritis.

Objective To observe the anesthetic effects of articaine hydrochloride and epinephrine tartrate injection in oral treatment of elder patients.Methods 66 teeth of 56 elder patients were treated.Pain intensity was scaled by VAS.Pulse and blood pressure were observed before and after drugs administration for 0,5 minutes.ResuIts Pain during injection of articaine hydrochloride and epinephrine tartrate injection and surgery subsequently was rare.The total respouse rate was 95%～100%.No significent toxic effects were found.Pulse and blood pressure remained after injection.Conclusion Articaine hydrochloride and epinephrine tartrate injection was one of local anesthetics with good infiltration,safety and anesehetic effect.It would be more widely used in elder patients oral treatment field in the future.