Objective To study the high-frequency ultrasound features of papillary thyroid microcarcinoma and pathological features.Methods The ultrasonic diagnostic features of 89 cases of papillary thyroid microcarcinoma were analyzed retrospectively,and the ultrasound results and pathological results were compared.Results In this study,high frequency ultrasound examination showed that the thyroid ultrasound diagnosis coincidence rate of papillary microcarcinoma was 94.4％.Patients mainly concentrated in 40 ～ 59 years,8 cases of type Ⅰ blood flow,16 cases of type Ⅱ blood flow,65 cases of Ⅲ blood flow,83 cases of L/T (aspect ratio).Conclusion The different pathological features of papillary thyroid microcarcinoma accompanied with the different ultrasound images.Doppler high frequency ultrasound in the identification and diagnosis of papillary thyroid microcarcinoma is accurate,convenient operation,and low cost,which is worthy of clinical application.

Stereotactic body radiation therapy (SBRT) has been increasingly used in the treatment of early-stage non-small-cell lung cancer (NSCLC).Different from conventional radiotherapy,SBRT is characterized by the delivery of high-dose radiation in 1 to 5 fractions with a high degree of precision and steep dose gradients that minimize the dose to normal tissues,and image guidance technology,image fusion technology and respiratory gating system make the therapy more accurate.SBRT delivers higher biological equralent dose (BED) than conventional radiotherapy.The latest small sample data have suggested outcomes for SBRT patients that superior to the success rate of surgery,and the evidence for SBRT over conventional radiotherapy has resulted in a major change in the standard of care for inoperable NSCLC patients.

Enterovirus 71 (EV71) is one of the major pathogens that cause hand foot and mouth disease.Epidemics and pandemics have been periodically reported worldwide.EV71 also can cause serous complications and lead death in children.The mechanisms of EV71 cause serious complications has remained unclear,may relate to many factors,including cell tropism,cell death and host immune responses.This article reviews the recent advances in the identification of factors determining EV71 cell tropism,the associated mechanisms of viral infection-induced cell death and the interplay between EV71 and immunity.

The pattern/symptom differentiation system in acupuncture treatment is lack of the unique characteristics and advantages in theory and clinical practice and it just rigidly adopts the methods of pattern/symptom differentiation of the other disciplines in TCM. In fact, it is necessary to have the unique and more practical theoretic system to guide acupuncture treatment. According to the characteristics of acupuncture in diagnosis and treatment, the acupoints selection based on "disease-symptom-location" combination becomes the law of acupuncture treatment. The acupoints selection based on "disease-symptom-location" combination is the expression to concretize the diagnosis and treatment of disease under the guidance of pattern/syndrome differentiation. Both of them are originated from the general principles of TCM and for the particular disciplines of TCM. The acupoints selection based on "disease-symptom-location" combination benefits the promotion and application of acupuncture.
Acupuncture Points ; Acupuncture Therapy ; Diagnosis, Differential ; Humans ; Meridians

Objective Inaccurate dosing is an important cause of medical malpractice, how to adjust the medication dose to overcome the excessive deviation will be discussed in this paper. Methods Gold zone method was proposed on the basis of the probability theory and mathematical statistics for handling inaccurate dosing problems. Investigation and study in large sample size was carried out on adverse reactions of Cefamandole Nafate for Injection by adopting the method. Results The conclusions from the super large sample size test indicate that there is highly significant difference of total adverse reaction rates between taking values within and outside golden zone of dosage, and the adverse reaction rate of taking values within golden zone is significantly lower than that of outside golden zone. It is noteworthy that when dosage was lower than golden zone,the adverse reaction rate was significantly increased,which is more than 4 times of that within golden zone. Conclusion It is effective measures and simply and easy to apply that taking values within golden zone of dosage reduce adverse drug reactions,probability within golden zone less than 1/4 range of experience that contains the actual demand of the body up to 70%.

Objective　To explore the correlative factors of ovulation-failure induced with clomiphene(CC) in polycystic ovary syndrome(PCOS).Methods　The relationship between ovulation rate(OR),ovulation cycle rate(OCR) among 178 cases,569 taking medicine cycles and clinical features,endocrine markers were retrospectively analysed.Results　OR was 73.0%,OCR was 45.3%,OCR of both the dysfunctional uterine bleeding(DUB) and anovulatory menstruation groups were markedly higher than those of secondary amenorrhea group(P＜0.005，0.05)，OCR of the DUB group was significantly higher than that in oligomenstruation group too(P＜0.05).OR of the nonpilosity and nonobesity groups were markedly higher than that of pilosity and obesity groups respectively(P＜0.01，0.005).OCR of the unmarried group was significantly higher than infertility and fertilized groups(P＜0.025，0.005).OCR of LH/FSH≥3 and serum testosterone(T) level-normal groups were respectively higher than LH/FSH＜3 and serum T level-elevated group(P＜0.05～0.025).There was markedly correlation among LH/FSH radio,T level,BMI and OR,OCR,PRL levels and OR(P＜0.05～0.01).Conclusions　The findings suggest that effect of the ovulation induced with CC in PCOS relate to types of menstruation,pilosity,status of marry-fertility,levels of LH/FSH,T,PRL.

With the progress of medical research,more and more inherited and congenital factors predisposing to hematologic malignancies have been revealed,which have brewed into a hot topic of the 56th American Society of Hematology (ASH) annual meeting in 2014.Correctly understanding and interpreting these innate susceptible factors will be of great significance in improving the treatment in patients and prevention or early detecting of cancers in individuals carrying these factors.Research progress in this area will be introduced together with the authors' research in this article.

Objective:To Integrated PACS and hospital information systems (HIS), and improve the efficiency of PACS, and improve the user experience. Methods:Base on deeply analysis of existing problems in system application, using process optimization, software optimization, and hardware upgrades manner optimize PACS. Results: PACS and HIS realized Integrated, improving the overall performance of the PACS. Enhance the user experience and expand the application scope of PACS. Conclusion: Deeply analysis of existing problems should be done before optimizing the system. Process optimization, software environment optimization should be considered as the most important and upgrading and replacement of the hardware as the secondary.

The heterospecies hybrid cells(HL-N)from the fusion of human promyelocy-tic leukemia mutant cells(HL-60-AR)and mouse bone marrow nucleated red cellswere established in HAT selective medium.Malignant phenotype comparative analy-sis between parental tumor cells and hybrid cells showed that growth ability ofhybrid cells was decreased.The hybrid cells reduced their DNA synthesis rate andlost the ability of colony-forming in 0.3% soft agar medium.The cells lost tumor-producing ability when they were transplanted into nude mice also.Inhibition orreduction of c-myc oncogene expression was demonstrated by Northern molecularhybridization techniques.The ultrastructure of hybrid cells were also different fromtheir parental cells.These results mentioned above showed that the mouse bone mar-row nucleated red cells might provide some peculiar factors(both nuclear factorsand cytoplasmic factors)to inhibit the expression of HL-60-AR cell malignant phe-notypes.