Objective:As a branch of image processing,image mining is a subject for great concern.With the development of image acquisition and storage,human can gain a lot of useful image information,but lack of effective analytic technique,so it is a focus of image mining that how to obtain useful image information and make full use of image information.So this paper gives an overview of the research and applications of image mining.Method:Firstly,it presents the concept and primary frame of image mining and the major techniques of lower layer image mining and higher layer image mining.Then,it discusses some applications in the biomedical,DNA analysis,data analysis of medical imaging and forensic medicine and so on.Result:Image mining is that the technique which can mine to discover new and valuable knowledge from vast collection of image.Conclusion:This article expounds the related technologies about image mining by our study of the image mining areas integrating the usual methods of the methods.Then,it identifies some applications in medicine and future research directions of image mining.

@@

OBJECTIVE:To investigate the reform mode of experiment teaching in pharmaceutical analysis in the new situation of vocational education and provide reference for improving the teaching quality of secondary vocational education. METHODS:The present situation of experiment teaching in pharmaceutical analysis was assessed deeply and in detail,and the problems exist-ing in teaching were analyzed;the reform plan and measures according to the disadvantages of the current teaching were raised. RE-SULTS:The experiment teaching in pharmaceutical analysis existed some problems,involving lagging textbook compilation,single teaching mode,“heavy theory,light practice”for time arrangement,obsolete laboratory apparatus and lack of advanced equipments. So a series of measures were adopted,including writing supplementary teaching materials and experimental guidance;reforming the contents of the experiment teaching;reforming the model of teaching and improving the students’participation;reforming the time arrangements;increasing the investment in laboratory equipment and attaching great importance to extramural cooperation;estab-lishing the virtual laboratory;and establishing a flexible,comprehensive and effective experimental evaluation mechanism.CON-CLUSIONS:Reform experimental teaching mode has fully mobilized the enthusiasm and initiative of students and improved the abil-ity of operating skills,and cultivated the strict scientific research style of students. The reform mode of experimental teaching in pharmaceutical analysis is in accordance with the students’learning needs of pharmaceutical majors,and lay a good foundation for the students better and faster adaption to the job.

Objective To examine the effect of somatostatin in the treatment of adhesive intestinal obstruction by meta-analysis. Methods Researchers extensively searched CNKI, Wanfang, and Pubmed and included articles which met the inclusion criteria.For each included article, researchers extracted the research methodology and the related indicators including gastrointestinal decompression, abdominal distension time, exhaust time and hospitalization time.We selected fixed effect models or random effect models to combine the effect of each variable according to the heterogeneity test results.Results Somatostatin could significantly reduce the amount of gastrointestinal decompression -213.19 mL/d (-252.97,-173.40), shorten the abdominal distension time-1.42 d( -1.71,-1.14), exhaust time-1.39 d( -1.79,-0.98), and the hospitalization time-3.46 d( -4.10,-2.83).Conclusion Somatostatin is effective in the treatment of adhesive intestinal obstruction.

BACKGROUND:Cartilage is an avascular tissue and has a limited capacity for self-repair after injury. There are various methods for the treatment of articular cartilage injury ranging from conservation therapy to invasive surgery. With the development of tissue engineering technology, it provides a new way for treating articular cartilage injury. OBJECTIVE:To review the new development of tissue engineering technology for repairing articular cartilage injury. METHODS:The PubMed database and CNKI database were retrieved for articles from 2000 to 2013 by the first author with computer in May 2013. The key words were“cartilage tissue engineering, cartilage defect, stem cell, scaffold, growth factor”in English and Chinese. A total of 64 articles were included which related to cartilage regeneration and cartilage tissue engineering. For the articles in the same field, those published recently or in authorized journals were selected. RESULTS AND CONCLUSION:The three elements of cartilage tissue engineering, seed cells, scaffolds and cytokines, must be coordinated and mutual y beneficial development. At present, the research of tissue engineering for repairing articular cartilage injury has made a great progress. But the application in clinic has not enforced yet which is limited in experimental exploration stage. With the continuous development of new materials, the new tissue engineering cartilage repair materials should meet the requirement of material science and biological science, thus making the materials closely meet the biological characteristics of the self tissues. The animal studies wil turn to clinical experiments with the support of new technique, which make a breakthrough in the treatment of articular cartilage injury.

Objective To establish a method to evoke cerebral potentials by stimulating nociceptive fibers with contact heat evoked potential stimulator,evaluate the state of nociceptive system in patients with multiple sclerosis and assess the value of the potentials in multiple sclerosis(MS).Methods Thirty-six definite MS patients and 40 sex-,height-and aged-matched healthy persons underwent stimulation of contact heat delivered via a circular thermode to excite selectively nociceptors with a rapid rising time at 70℃/s to elicit pain and contact heat evoked potentiaI(CHEP).Thermal stimuli were sent at two intensity levels (47 ℃ and 51℃)to 3 body sites:volar surface of the forearm,the skin of leg 5 cm proximal to the medial malleolus and lumbar part.The CHEP were recorded from Cz.The relationship between the stimulus intensity and pain rating was observed,and the main components of the evoked potential were recorded.Then,somatosensory evoked potential(SEP)was examined in 36 patients with MS.Results CHEP were elicited reliably and stably in all control subjects.In contrast,in 4 patients there were no recordable CHEP on stimulation of the upper limb,and in some cases of lower limb(n=5).Conduction velocity of Aδ fihers was(18.1±7.3)m/s.The 21 MS cases had hypesthesia in upper limb and 29 cases in lower limb.The visual analog scale(VAS)for pain perception was higher in control subjects(upper limb:8.0±0.7;lower limb:7.9±0.7)than MS with hypesthesia(upper limb:6.1±0.9;lower limb:5.6±1.3,Z=-3.249 and -5.272,both P＜0.01).The group of patients (MS) with hypesthesia(upper limb 17 cases,lower limb 24 cases)had markedly reduced N-P amplitudes(upper limb:(30.5±12.8)μV;lower limb:(28.2±16.2)μV,t=-4.612 and -3.144,both P＜0.01)and prolonged N-wave latencies(upper limb:(387.3±34.2)ms;lower limb:(489.9±70.2)ms,t=4.790 and 4.798,both P＜0.01)compared with the control group in CHEP mediated by Aδ fibers.CHEP abnormality was observed more often in the lower(26/36,72.2%)than the upper limb(16/36,44.4%,P=0.031)and SEP(19/36,52.8%,χ~2=4.261,P=0.039).CHEP were abnormal in 3 of 15 skin areas with clinically normal nociception in upper limb,and in some cases of lower limb(2 of 7).Conclusions CHEP provides a clinically practical,non-invasive and objective measure,and can be a useful additional tool for the assessment of nocieptive system.Combined assessment of other Eps can help to document dissemination of demyelinating CNS lesions and detect subclinical lesions thus contribute to the diagnosis of multiple sclerosis.

BACKGROUND: Fiber post is widely used in front teeth aesthetic repair, but some defect teeth cannot form ferrule or thick root canal, which resulted in fiber post prosthetic replacement defluxion and a failure of repair. Presently, new-style resin cement had self sticking component, showing good effects in sticking of fiber post. Whether combination of new-style resin cement can repair affected teeth using fiber post deserves further investigation.OBJECTIVE: Through fatigue test, residual flexural strength and scanning electron microscope (SEM) observation to compare the strength of severely weakened roots restored with three resin cements. METHODS: Eighteen intact maxillary central incisors were collected and formed to severely weakened canals at the same size. Three kinds of resin cements were used to restore. Rely X Unicem, Panavia F and Super-Bond C&B resin cement and identical glass fiber post were used. All the specimens were restored using Ni-Cr ceramic crown, and placed on TCML chewing machine that loaded 1 200 000 cycle forces, and the cycle times when failure occurred were recorded. The samples were intact following loading received residual flexural strength testl SEM was employed to observe breakage surface of the samples. RESULTS AND CONCLUSION: Mean cyclic loading was significantly greater in the Super-Bond C&B Group (1 200 000 times) than in the Relyx Unicem Group (640 000 times) and Panavia F Group (550 000 times) (P< 0.05). No significant difference was detected between the Rely X Unicem and Panavia F Groups. Residual flexural strength was 747.99 N in the Super-Bond C&B Group. SEM demonstrated that Super-Bond C&B formed longer resin processes, which were more than other two groups. Results confirmed that Super-Bond C&B demonstrated better results when restoring flared roots with prefabricated glass fiber posts.

10% at 24-hour later than the initial value.Conclusion In patients with refractory septic shock who achieved the goal of combiming CVP ≥ 8mmHg,MAP ≥ 65mmHg,SmVO2 ≥ 65% hyperlactemia was ameliorated.Lactate clearance rate can be used as a good marker to predict outcome of septic shock patients.

Objective To evaluate the functional alternations of canine renal ischemia and reperfusion injury by using MR perfusion-weighted imaging, and to correlate the imaging with the pathologic findings. Methods Using 1. 5 T MR system, four groups of three anesthetized dogs each were studied by left renal artery ligation for 30-, 60-, 90-, and 120-min, respectively, after the removal of ligation, reperfusion injury was suffered for one hour. True-FISP, TSE, and EPI sequences were performed in five different time phases ( pre-ischemia, onset-ischemia, post-ischemia, onset-reperfusion, and post-reperfusion). Finally, IR-turbo-FLASH sequence (TR 5. 8 ms, TE 3. 2 ms, TI 400 ms, FA 12?) with a temporal resolution of 1. 16 s was performed. Signal intensity (SI) in cortex, outer medulla, and inner medulla was measured. SI was plotted as a function of time. Peak height (P) , time to peak (Tp) , and the area (A) under the time-course curves after the intravenous injection of Gd-DTPA were estimated. Blood and urine examples were collected for measuring serum creatinine level and urinary protein before and after the insult. Histologic examination was performed with light and electron microscopy in all dogs. Results After arterial ligation,there was marked and significant reduction in the SI of each layer of left kidney on true-FISP, TSE, and EPI, except for the SI of inner medulla on TSE. After the removal of ligation,there were no significant differences in the SI of cortex of both kidneys, however, significant differences in the SI of outer and inner medulla of both kidneys remained on EPI in all groups. The turbo-FLASH study clearly depicted the three-phase pattern of SI changes in each layer on right kidney. The uniphasic enhancement pattern in all groups was showed in outer and inner medulla on left kidney, with the area under the curve decreased. Conclusion This preliminary study shows that MR perfusion-weighted imaging may be useful and very promising for the evaluation of renal dysfunction following normothermic ischemia and reperfusion injury.

The ultraviolet spectrophotometric method for determination of vitamin A in breast milk was simplified. The milk sample was extracted directly with ammonia water, ethyl alcohol and ether, the saponification procedure be- ing omitted. The optimal height of the aluminum oxide adsorption column and the optimal rate of flow for elution were developed. The observation was made whether the elution for vitamen A was complete by identifying the fluorescence of vitamin A directly under ultraviolet light in the eluat-es collected instead of SbCl3-Vitamin A blue color reaction. The simultaneous estimation of Vitamin A in breast milk and in the standard solution of Vitamin A with this method showed E300nm/E325nm less than 73%, agreeable with the British Pharmacopoeia. The recovery was 100.8%. This procedure has advantages of high sensitivity, simplicity, time saving and economy.