New progress of myelodysplastic syndomes (MDS) in the 55th ASH annual meeting on 5-azacytidine and decitabine was reviewed.Except in older females,the survival time for a diagnosis of MDS in the United States does not seem to have substantially improved since the introduction of 5-azacytidine into the market in 2004.However,clinical and mechanism data suggest that judicious,mechanism-based application and optimization of these agents will have increasingly meaningful impact.Moreover,these drugs are exemplars of an inspiring alternative to the traditional cytotoxic paradigm and should pave the way for additional relatively nontoxic but broadly effective agents.

Objective To research the quality management technique of medical device that as an important technique of medical engineering department in hospital is a guarantee of the hospital's development.Methods The definition,elements,signification and extension of management technique,elaborated the technique process and requirement of the quality control in hospital were introduced.Results Following an analysis of the quality control system and actualizing methods,perspective and current objective of the accident report system,legal and systemic quality management,as well as the role and responsibility of medical engineering practitioner were discussed.Conclusion The quality level of hospital will be fully improved depending on establishment of the quality management technique for medical device.

Objective The diagnosis and treatment of modern hospital are greatly influenced by medical devices. With the widespread introduction of medical equipment, the scientific management how to carry on the instrument and appliance by the administrative department of hospital becomes an unavoidable problem. Methods Based on the definition of medical equipment, basic attributes and management skills, some key questions which the administrator should notice and solve in the scientific management are introduced, and gives out the principle and method. Results It is pointed out that scientific management can correctly guide the investment of equipment, and gain great benefit with a minimum input. Conclusion Investment according to the developmental strategy is proposed, which provides strong theoretical basis for leadership and administrative departments.

Central nervous system(CNS) disease induces functional deficits in persons.Simultaneously,there appears axonal destruction and the formation of scar tissue,as well as cavity and physical gaps in the lesions.Olfactory ensheathing cells(OECs),acting as prime candidates for autologous transplantation,secrete neurotrophic factors for neuroprotection,angiogenesis and outgrowth of both intact and lesioned axons to different degrees,change the response status of endogenous glia after lesion,as well as remyelinate axons after a range of demyelinating insults.OECs transplantation has become an ongoing clinical therapeutic approach for human CNS disease in recent years.Thus,OECs transplantation can be used for cell-mediated repair following a variety of CNS lesions.Here,the paper reviews the current status of foundational research of OECs transplantation in treating CNS disease underlying the wide variation of results obtained in the field.

The indexes of teaching quality evaluation,such as attitude,teaching and evaluation,contents and methods,and evaluation standards,such as "excellent,good,medium,bad,worse",show the characteristics of inaccuracy.While traditional evaluation methods focus on accurate figures,the paper proposes a new method which is based on fuzzy mathematics to evaluate teaching quality.The theory,computing procedure and examples of the method are introduced.

Objective To study the changes of apoptosis in brain after traumatic injury(TBI)treated with exogenous vascular endothelial growth factor(VEGF)gene therapy in oder to find out the role of exogenous VEGF gene in protectiog brain tissue.Method The injurea cerebral cortex from the rat models of brain with traumatic injury was injected with adenovirus(adenovirus,Ad)as the carrier of VEGF-165 gene(Ad-VEGF-165 Gene).RT-PCR and Western blot were used to detect the expression of VEGF mRNA and VEGF protein in the brain 6 h,24 h,3 d,7 d and 14 d after injury,and apoptosis in the injured location of brain was also detected by TUNEL successively after Ad-VECF-165 gene therapy.Results With exogenous Ad-VEGF-165 applied to the locally injured brain tissue after injury,VEGF mRNA and VEGF protein showed consistent expression and their expressions were significantly higher than those in trauma group and vehicle control group.Compared with the trauma group.the apoptosis in the gene therapy group 24 h,3 d and 7 d after injury presented a.significant reduction,and had close relationship with VEGF.(Control group:4.17±0.73;TBI group,24 h:47.18±6.01,3 d:79.44±11.23;TBI+VEGF group.24 h:28.72±5.31,3 d:54.18±7.66;P＜0.05).Conclusions The exogenous VEGF gene therapy administered to have protective effects on the local brain tissue in rats with traumatic injury in a certain time.

Objective To observe the therapeutic effect of intermittent pneumatic compression pump to prevent deep venous thrombosis for patients after hip surgery. Methods A total of 104 bedridden patients 72 hours after hip surgery were divided into the treatment group and the control group. Patients in the control group were administrated routine antithrombotic drugs and active functional exercise. While patients in the treatment group were provided with intermittent pneumatic compression pump as assistant based on the routine treatment and active functional exercise. The condition of deep venous thrombosis in the two groups were observed. Results Intermittent pneumatic compression pump had remarkable therapeutic effect on preventing deep venous thrombosis of lower extremity for patients lying in bed over 72 hours after hip surgery. Conclusions Intermittent pneumatic compression pump as an assistant treat -ment based on the routine antithrombotic therapy contributes to prevent deep venous thrombosis of lower extremity for patients lying in bed over 72 hours after hip surgery.

Objective Through the statistical analysis of the student assessment on curriculum quality,through the observation of the current curriculum teaching situation and its cheracteristics to promote the curriculum construction effectively and improve the medical teaching quality.Methods The current study is carried out among 2 841 undergraduates who study in varied majors and different grades in a medical university.A table of Student Evaluation of Course Teaching Quality developed by the researcher is applied to the questionnaire survey and statistical analysis including comparation means test and correlation tests are adopted in the present study to analyze the course teaching quality.Results Initially.the National Selected Model Courses show no significant difference from the common courses;secondly,three variables including teaching content adopting the course syllabus,good professional qualification and teaching capability of teachers and advanced teaching methods and techniques ale highly scored among ten variables;thirdly,the correlation coefficient of the variable of improving self-learning ability and total score is statistically significant and it can be observed higher than that of other variables and total score.Conclusion Establishing student-centered curriculum evaluation and construction of long-effect mechanism,and developing the students'ability of autonomous learning ale important to improve the quality ofthe course.

Delayed cerebral vasospasm is the leading cause of death in patients with subarachnoid hemorrhage. A good in vivo animal model of cerebral vasospasm after subarachnoid hemorrhage helps to understand the occurrence, development of this cerebral vasospasm, and the complicated and various pathophysiological mechanisms. It will provide important information for clinical interventions

BACKGROUND:With elevated medical levels, limb salvage surgery for limb malignant tumor is valuable day by day. At present, the limb salvage surgery has substituted amputation and becomes mainstream and development direction of present surgical treatment of limb tumors. However, so far, there are no unified surgical indications for proximal femur tumor, which are controversial. OBJECTIVE:To investigate the efficacy of artificial total hip arthroplasty combined with extended resection of tumor sections for proximal femoral bone tumors. METHODS:Patients with proximal femoral bone tumors in the Second Xiangya Hospital of Central South University were selected and divided into control group and observation group, with 30 patients in each group. According to the disease, lesion curettage, aneurysm wal inactivation, autologous and (or) al ogeneic bone, mixed bone graft and bone graft fixation were selected to treat the control group. The observation group patients received extended resection of tumor sections and total hip arthroplasty. The operative time, intraoperative blood loss, hospital stay and joint function of two groups were compared. 2 years later, patients were revisited. Metastasis and recurrence rate, death rate and quality of life of two groups were compared. RESULTS AND CONCLUSION:There was no significant difference in intraoperative blood loss and surgery time between the two groups (P>0.05). However, hospital stay of patients in the observation group was shorter than the control group. The excellent and good rate of recovery of joint function (83%) was higher in the observation group than in the control group (53%). The metastasis and recurrence rate within 2 years after surgery (7%) and death rate (3%) were lower in the observation group than in the control group (30%, 23%). Various indicators of quality of life of patients in the observation group were significantly better than the control group (P<0.05). These results confirmed that artificial total hip arthroplasty in the treatment of proximal femur tumors is safe and effective.