Abscess ; Anus Diseases ; Cough ; Fever ; Humans

Objective To investigate the changes before and after docetaxel chemotherapy and significances of T lymphocyte subsets of patients with non-small cell lung cancer.MethodsThe clinical data of 100 cases of patients with non-small cell lung cancer treated in our hospital from January 2013 December 2016 were retrospectively analyzed, these patients were regarded as lung cancer group, another 100 cases of healthy subjects in our hospital received over the same period were selected as healthy group, the changes of T lymphocyte subsets of the two groups were statistically analyzed.ResultsThe CD+3, CD+3CD+4, CD+4/CD+8, NK cells before and after chemotherapy of the lung cancer group were significantly lower than the healthy group (P<0.05), the CD+3, CD+3CD+4, CD+4/CD+8, NK cells before chemotherapy were significantly lower than after chemotherapy (P<0.05), the difference of CD+4/CD+8 between the two groups was not significant;The CD+3, CD+3CD+4, CD+4/CD+8, NK cells of the disease control patients in the lung cancer group were significantly lower than the disease progression patients, healthy group (P<0.05), the differences of CD+3, CD+3CD+4, CD+4/CD+8, NK cells between the disease control patients and healthy group were not significant, the difference of CD+4/CD+8 between the two groups was not significant.ConclusionThe changes of T lymphocyte subsets before and after docetaxel chemotherapy of patients with non-small cell lung cancer can provide effective basis for clinical evaluation of cellular immune function and efficacy of chemotherapy of patients with non-small cell lung cancer, so is worthy of the clinical's full attention.

Objective:To establish the methods and standard for the evaluation of rational application of parenteral nutrition ( PN) in primary hospitals. Methods:Medical records with the use of fat emulsion, amino acids (17) and glucose (11%) injection were col-lected. The integrity of the medical records was analyzed, the compatibility of supplementary drugs was evaluated, and basal metabo-lism rate(BMR) was calculated for the relevant assessment. Results:Totally 66. 7% of the patients had incomplete basic parameters of nutritional risk assessment, the cases had different course of treatment but showed no significant difference in total usage of fat emul-sion, amino acids (17) and glucose (11%) injection,and the non-protein calories of fat emulsion, amino acids (17) and glucose (11%) injection accounted for 72. 1% of basal metabolism rate of an individual on average (S=8. 9). Supplementary usage of KCl accounted for 63. 0% of the cases, of which 70. 6% were overdosed;62. 9% of the cases used supplementary alanyl-glutamine with overdosage. Conclusion:In the PN application in our hospital, nutritional risk assessment is basically missed, and there is a great gap between the level of developing reasonable individual program and the requirements in guidelines. Clinical pharmacists should enhance the related monitoring and evaluation in PN application.

Objective　To Investigate the pathogenesis of chronic idiopathic urticaria.Methods　Basophil histamine release assay was utilized.Result　15 of 32 cases(46.9%)had increased serum histamine releasing activities. This implied that anti-FcεR1 and anti-IgE autoantibodies existed in the sera of some patients with chronic idiopathic urticaria.Conclusion　It suggested that autoimmunity might take part in the occurrence of some patients with chronic idiopathic urticaria.

The incidence of α-thalassemia and β-thalassemia is high in Guangxi,Guangdong,Sichuan and other province in China.Because no effective approach to thalassemia treatment could be used clinically now,the most cost-effective strategy to control this disease is to prevent the birth of babies with severe form of thalassemia.It is important to make effective screening and correct diagnosis of thalassemia by laboratory test.Laboratory diagnosis of thalassemia includes routine diagnosis and genetic diagnosis.The laboratory routine tests are some hematology examination,comprising red blood cell indices,erythrocyte osmotic fragility test,hemoglobin analysis,and others.Anyone alone of these laboratory parameters can not be used to diagnose the carrier of thalassemia.It is necessary to combine these tests to make screening diagnosis.The final diagnosis of thalassemia need to perform the gene mutation examination or globin train analysis.Technologies for gene mutation detection have been the main and gold standand method of diagnosing thalassemia now.

Objective To evaluate the value of spiral CT in diagnosis and treatment of lung lesions in clini-cal work.Methods A retrospective analysis of 100 patients with pathological diagnosis of lung lesions patients were randomly divided into the control group (CT normal scan)and observation group (CT -D post -processing tech-niques).Lungs lesions,hilar and mediastinal lymph node metastasis sensitivity,specificity and accuracy of lymph node metastasis of both group were analyzed.Results In the control group,the diagnosis of lung lesions showed sensitivity of 75%,specificity of 50% and accuracy of 72%;while in the observation group the sensitivity was 80%,specificity was 65 % and accuracy rate was 85%.The differences between the two groups were statistically signficant(χ2 =3.854,4.604,5.007,all P <0.05).50 cases of pathologically verified as lung cancer patients with hilar lymph node metastasis in the control group showed diagnostic sensitivity of 60%,specificity of 72%,accuracy of 70%;while diag-nosed hilar lymph node metastasis in the observation group showed sensitivity of 76%,specificity of 84 percent and accuracy rate of 84%.The differences between the two groups were statistically signficant(χ2 =5.882,4.196,5.534, all P <0.05).50 cases of pathologically verified as lung cancer patients with mediastinal lymph node metastasis in the control group,showed diagnostic sensitivity of 62%,specificity of 57% and accuracy of 60%;in observation group the sensitivity was 72%,specificity was73% and accuracy was 72%.The differences between the two groups were statisti-cally signficant(χ2 =4.342,5.626,4.583,all P <0.05).Conclusion The spiral CT for diagnosis of lung lesions positioning has good effect,and can be widely used in the diagnosis of lung lesions.

OBJECTIVE:To explore the effects of Compound Ligusticum chuanxiong drop pill on hemorheology and blood gas in model rats with diabetic nephropathy(DN). METHODS:60 rats were randomly divided into normal control group,model group, positive control group [Irbesartan tablet,0.013 g/(kg·d)] and Compound L. chuanxiong drop pill high-dose,medium-dose,low-dose groups [0.4,0.2,0.1 g/(kg·d)],10 in each group. Except for normal control group,rats in other groups were given high-sugar high-fat feed and intraperitoneally injected streptozotocin to reduce DN model. After 7 d modeling,rats in each group received relat-ed drugs intragastrically,once a day,10 mL/kg;normal control group and model group received equal volume of purified water in-tragastrically. After 64 d,hemorheology indicators [whole blood viscosity(high-shear,medium-shear and low-shear),plasma viscosi-ty,whole blood reduced viscosity] and blood gas indicators(carbon dioxide partial pressure,oxygen partial pressure,hemoglobin content,oxygen saturation,ratio of oxygenated hemoglobin to total protein) of rats were determined,hematoxylin-eosin staining was used to observe the pathological changes in kidney tissue. RESULTS:Compared with normal control group,hemorheology indi-cators and carbon dioxide partial pressure in model group were significantly increased(P<0.05 or P<0.01),oxygen partial pres-sure,hemoglobin content,oxygen saturation,ratio of oxygenated hemoglobin to total protein were significantly decreased(P<0.05 or P<0.01),with severe kidney damage. Compared with model group,except the improvement of carbon dioxide partial pressure, oxygen partial pressure,hemoglobin content in rats were not significant in Compound L. chuanxiong drop pill low-dose group,the above-mentioned indicators in other medicine groups were significantly improved(P<0.05 or P<0.01);the kidney tissue damage was improved to varying degree. CONCLUSIONS:Compound L. chuanxiong drop pill can significantly improve the hemorheology indicators of DN model rats,reduce blood viscosity,improve microcirculation and capacity of the blood to transport oxygen,and has certain improvement effect on kidney tissue morphology of DN rats.

The postoperative management of papillary thyroid microcarcinoma (PTMC) is one of the most important parts of management for PTMC,and it includes the initial management and long-term management of PTMC.The initial management of thyroid cancer is based on initial recurrence risk stratification system.The initial risk stratification system can be used to guide initial TSH suppression therapy,RAI assistant therapy and management of follow up.Initial risk assessment of recurrence,as a static representation of the patient in the first few weeks post-operatively,could not be continually updated during follow up.In order to account for the changes of the recurrence risk and disease specific mortality,re-stratification of risk should be performed during follow up,using all the clinical,biochemical,imaging (structural and functional),and cytopathologic findings obtained during follow up.Re-stratification of risk can inform clinicians on degree of ongoing TSH suppression,frequency and intensity of follow-up,and need for additional therapies were recommended in guideline.Adjustment of TSH suppression therapy should incorporate the impact of side effects and set TSH targets to ensure the benefits of TSH suppression outweigh against the potential risks.

Sheep with chronic lung lymph fistula were used as model, lung injurywas induced with endotoxin, changes of pulmonary phospholipase A_2(PLA_2) activity wasmeasured and the effect of dexamethasone on PLA_2 activity was also observed. The resultsshowed that after endotoxin infusion PLA_2 activity, thromboxane B_2 (TXB_2) and 6-Keto- prostaglandin F_1? (6-Keto-PGF_1?) increased markedly (P

Objective To explore early prognostic value of quantitative detection of paraquat (PQ) plasma concentration and urine sodium dithionite assay for prognosis in patients with acute PQ poisoning. Methods A prospective study was conducted. The patients with acute PQ poisoning admitted to Department of Emergency of First Hospital of China Medical University from August 2013 to December 2015 were enrolled. At admission, blood samples and urine samples were collected. The PQ plasma concentration was determined by high-performance liquid chromatography (HPLC), and the PQ urine concentration was determined by sodium dithionite, meanwhile the biochemical parameters were determined to carry out sequential organ failure assessment (SOFA) score. According to the prognosis of 90-day follow-up, the patients were divided into survival group and death group. Logistic regression analysis was used to analyze the relationship between the prognosis and the indexes, and the receiver operating characteristic curve (ROC) was drawn to evaluate the prognosis. Results There were 148 patients with acute PQ poisoning, with 43 alive and 105 dead, and the 90-day mortality rate was 70.9%. The ingestion volume (mL: 22.69±18.57 vs. 9.91±4.61), plasma concentration of PQ (mg/L: 2.28±1.52 vs. 0.91±0.38) and positive rate of urine sodium dithionite (87.6% vs. 14.0%) in death group were significantly higher than those of survived group (all P < 0.01), but no significant differences in gender, age, poisoning time, gastric lavage time between the two groups were found. Significant differences in white blood cell count [WBC (×109/L): 13.45±6.12 vs. 23.03±7.67] and blood lactate [Lac (mmol/L): 1.50±0.45 vs. 8.10±4.51] between survival group and death group were found (both P < 0.01), while no significant difference in SOFA score was found (0.98±0.72 vs. 1.34±1.29, P > 0.05). It was shown by logistic regression analysis that the key factors affecting the prognosis of patients with PQ poisoning were urine sodium dithionite assay [odds ratio (OR) = 8.731, 95% confidence interval (95%CI) = 2.828-26.954, P = 0.000], PQ plasma concentration (OR = 2.082, 95%CI = 1.204-3.603, P = 0.009) and ingestion volume (OR = 1.175, 95%CI = 1.048-1.318, P = 0.006) respectively. It was shown by ROC curve that the area under ROC curve (AUC) of plasma PQ concentration, urine sodium dithionite assay, poisoning dose and SOFA score for predicting the prognosis in patients with acute PQ poisoning was 0.866, 0.857, 0.826, and 0.631 respectively (all P < 0.05). The sensitivity of urine sodium dithionite assay for predicting the prognosis was 87.6%, and the specificity was 83.7%. Conclusions Early plasma PQ concentrations can objectively reflect the body absorbed toxicant doses and actual situation after poisoning, and help to judge the early evaluation of prognosis. The accuracy of urine sodium dithionite assay in judging the prognosis of PQ poisoning is high. Because of its simplicity and availability, it was easier to be performed in the primary hospital.