The paper discusses whether to maintain nonhealthy foetus,the bearing control of patients with hereditary diseases,the aim to apply the technique to distinguish foetus' sex and personal morals and social ethical problems for health staff to do that,points out that the technique can be applied only to check hereditary diseases as to be benefit to bearing good child and arising people's quality ,and the techique should be controlled properly as not to serve for feudal ethic.

Objective To investigate the state of self-perceived burden (SPB) and depression and to explore the relationship between them for patients with chronic respiratory diseases.Methods 95 patients with chronic respiratory diseases were investigated by the Self-Perceived Burden Scale (SPBS) and Self-Rating Depression Scale (SDS).Results The average score of SPBS was (33.64±10.23) points,which was at the middle level,90.5％ of patients showed different levels of burden,and 34.7％ of patients were at the high level.The average score of SDS was (50.23±11.93),the index was 0.63,which was at the middle to high level,74.7％ of patients showed different levels of depression,and 33.7％ of patients were at the high level.There was a positive conrelation between SPB and depression.Conclusions Patients with chronic respiratory diseases had obvious SPB and depression,and there was a close relationship between them.With chronic respiratory diseases breaking out repeatedly and more severe year by year,most patients have high level of burden and negative emotions.Nurses should take proper measures and psychological interventions to help patients face to the diseases optimistically,and to improve patients' emotion state and enhance their physical and mental health.

Alzheimer Disease ; pathology ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Rhodiola

With the wide application of Chinese herbal medicine, herb-drug interaction (HDI) has become increasingly prominent. Metabolic enzymes and transporters are the main targets of HDI, because the changes in expression and function of enzymes and transporters can influence the disposition of drugs. Metabolic enzymes are responsible for the metabolic clearance of drugs, including cytochrome P450 (CYP), UDP-glucuronyl transferase (UGT) and sulfotransferases (SULT); transporters widely expressed in the intestine, kidney, liver and brain are involved in the oral absorption, distribution and excretion of drugs. Pueraria, ginkgo, ginseng, St. John's wort and other Chinese herbal medicine often induce a HDI because those herbal medicines combined with chemical medicine are widely used in clinic. The components of herb medicines mentioned above are prone to interact with enzymes and transporters, which often induce a HDI. This paper reviews the advances in the study of enzymes and transporters-mediated pharmacokinetic mechanism of HDI.

Ovarian cancer is highly lethal despite multiple therapies, and new therapies are therefore needed.Retinoids are potential anticancer drugs that can promote apoptosis,inhibit growth and induce differentiation in cancer cells,and all these functions are regulated by the expression of retinoid receptors.Herein the recent researches on the expression of retinoid receptors in ovarian cancer are reviewed.

Health Personnel ; Humans ; Infection Control ; Infectious Disease Transmission, Patient-to-Professional ; Occupational Diseases ; prevention & control

there are abundant products and fierce competitions in the market of skin-care products,which on the one hand provide customers with multiple choices,but on the other hand also make it difficult for customers to choose proper products.Under this circumstance,it is quite possible to create a new career of skin-care-consultant,which serves as a communication bridge between customers and skin-care products.This paper aims to clarify the ethical significance of the new-rising career of skin-care-product consultant.

Objective To investigate the relationship between metabolic syndrome and colorectal cancer. And to further prevent the risks of colorectal cancer and provide methods and evidences.Methods A literature search was performed through CNKI,Wanfang,PubMed,Ovidsp,Cochrane data within the time limit of November 2005 to November 2015.According to the inclusion and exclusion criteria,the studies were screened and the data were extracted.Then,meta -analysis was performed using Review Manager 5.3.5.Results A total of 14 studies(6 case-control studies and 8 cohort studies)met the inclusion criteria.Meta analysis showed that with metabolic syndrome had a higher risk of colorectal cancer incidence compared with the control group without metabolic syndrome(OR =1.18,95%CI:1.33cv1.22,P <0.05).Stratified analysis showed that metabolic syndrome increased the risk of color-ectal cancer between men and women population.The combined effect of the OR respectively (OR =1.12,95%Cl:1.09 -1.14,P <0.05;OR =1.13,95%Cl:1.05 -1.22,P <0.05),the differences were statistically significant. Meta analysis showed that metabolic syndrome was not associated with an increased risk of colon cancer mortality (OR =1.05,95%CI:0.92 -1.19,P =0.46).Conclusion This meta analysis indicate a positive association between meta-bolic syndrome and colorectol cancer incidence,and the association has no gender differences.The metabolic syndrome does not increase the risk of colon cancer death.More prospective cohort study needed to further confirm it.

The alkaline elution and fluorometrie DNA assay were adapted to the evaluation of DNA single-strand breaks in the cultured human fetal lung 2BS cell. the DNA damage was induced in vitro by the treatment with Alternariol monomethyl ether (AME) and Alternariol (AOH) which were the main mycotoxins of Alternariol alternata. The results showed that both AME and AOH could induce the DNA single-strand breaks in the cultured human fetal lung 2BS cells and there existed the dose-response association betweenthe fractions of DNA remaining on the filters and the doses. The fractions of DNA remaining on the filters were 0.57?0.04, 0.45?0.02, 0.30?0.02, 0.18?0.01 respetively under the AME concentration of 10, 25, 50, 100?g/ml and were 0.68?0.3, 0.54?0.01, 0.47?0.03, 0.34?0.01 respetively under the AOH concentration of 0.1, 1, 5, 10?g/ml when DNA was eluted for 6hr. It were significantly different from the fractions by solvent control (0.87?0.02) (P

Objective To evaluate the chemoprevention and therapy of tea polyphenol of colorectal cancer in colon cancer rats and cells.Methods Such database as CBM,CNKI,VIP,Wanfang,PubMed, Medline,EMBase,Cochrane Library were searched for collecting the papers including using tea polyphenol as a therapy and chemoprevention of colorectal cancer in colorectal cancer rats and colorectal cells,from their estab-lishment to June 1 ,201 4,and the references of those related papers were also searched by hand.After studying selection,assessment and data extraction were conducted by two reviewers.RevMan5.2 software was used for Meta-analyze.Results Seventeen studies were included.Three hundred and five rats and 5 colorectal cell lines were used to the research,they were divided into the study group (received the tea treatment)and the control group (not received the tea treatment).The results of meta-analyses showed that:① Aberrant crypt foci (ACF):standardized mean difference SMD =-3.69 (95%CI 为 -5.85 ~-1 .54,Z =3.40,P =0.000 8),which indicated that tea polyphenol could reduce the number of ACF.② The average number of tumors per rat:SMD =-0.83 (95%CI:-1 .1 4 ~-0.51 ,Z =5.1 8,P =0.000 01 ),which indicated that tea polyphenol could reduce the average number of tumors per rat.③ Cell cycle G1 phase:SMD =1 .85(95%CI:0.03 ~3.66,Z =1 .99,P =0.05 ),which indicated that tea polyphenol could increase the cell in G1 phase.④ Cell cycle S phase:SMD =-2.64(95%CI:-4.38 ~-0.90,Z =2.98,P =0.003),which in-dicated that tea polyphenol could decrease colon cancer cell in S phase.Conclusion Tea polyphenol has a positive effect on colon cancer cell and colon cancer rats.