Objective To investigate the impact of different surgical methods and different doses of euthyrox on bone mineral density.Methods A sample of 40 patients received thyroid cancer operation (excised affected side leaf,aisthmus,most of offside and neck VI lymph node dissection)and 40 patients received nodular goiter operation (excised affected side leaf)were collected,the dose of euthyrox taken in was 85 .2μg in thyroid cancer patients and 36.2μg in nodular goiter patients daily,the bone mineral density 6 month and 1 year after operation was detected. Results There was no difference of BMD between the two group 6 month after operation (P>0.05),but BMD of the observation group was (0.64 ±0.28)g/m2,which was lower than that of control group (t=2.235,P=0.03).Com-pared with pre-operation,BMD of control group had no change and the observation group appeared drop 1 year after operation.Conclusion Patients received thyroid cancer taking in euthyrox may show BMD reduced,especial 1 year after operation,doctors should be on the alert and supplement calcium appropriately.

(0.05)).Conclusions PE is an effective form of treatment for recurrent FSGS by removing circulating factor,especially if initiated early.Failure to achieve remissions and maintain stable remission after the initial period of PE imply a poor outcome and glomeruli lesion been sclerosis.Therefore,PE should be performed as early as possible until completely remissions.

Objective:To investigate the relationship among serum uric acid,C-reactive protein and the degree of carotid artery atherosclerosis in patients with essential hypetension.Methods:122 patients with essential hypertension were divided into intima-media thickness group(Ⅰ),plaque development group(Ⅱ) and vessel stenosis group(Ⅲ).Concentration of serum uric acid and C-reactive protein were measured in each patient and the relationship between serum uric acid and C-reactive protein was observed.Results:The concentrations of serum uric acid and C-reactive protein in group Ⅱ and Ⅲ were positively connected with pathologic changes of carotid artery atherosclerosis( P

Objective:To investigate the effects of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease.Methods:45 patients with chronic congestive heart failure due to coronary artery disease were divided into two groups,23 patients in trimetazidine group and 22 in placebo-control group.The echocardiogram indices of cardiac function of patients in two groups-SV,CO,CI,LVEF,VA,VE and VA/VE were measured before and after treatment.Results:The indexes SV,CO,CI and LVEF were significantly higher in trimetazidine group than those in control group(P0.05).Conclusion:Trimetazidine can improve systolic function of ischemic heart by improving the energy metabolism of ischemic heart.

A lot of children with congenital heart disease have an abnormal development of nervous system. A variety of biochemical and physical examination indices can be used to predict adverse outcome of neurodevelopment caused by congenital heart disease and they contribute to early intervention and improvement of neurodevelopmental disorders. In recent years, new progresses in the laboratory tests, neurological physiccal examination and perioperative management of the neurodevelopmental abnormalities caused by congenital heart disease have been made. The predictive factors of abnormal neurodevelopment caused by congenital heart disease were reviewed in this article.

The data of 1 case diagnosed with hyperphenylalaninemia (HPA) combined with Cornelia de Lange syndrome (CdLS) by neonatal screening in Newborn Disease Screening Center, Liaocheng Maternal and Child Health Hospital in February 2018 were analyzed retrospectively.The patient was a girl, 22 months old, with clinical features of specific facial appearance, excessive body hair (especially on the forehead and face), dark and thick hair on the head, a low hairline, a heavy and straight brow, lower ear positions, a small nose, a shallow philtrum, a simian line, strong and rhythmic heart sounds, no murmur in the precordial area, clear respiratory sounds of both lungs, purple marbling patterns on the whole body skin, a soft abdomen, and high muscle tension of limbs.The gene mutation c. 1256A>G(p.Q419R) of the polyclonal antibody( PAH) originated from the patient′s mother, while the mutation c. 4421G>A(splicing) derived from the patient′s father. SMC1A gene was X-linked dominant inheritance, and c. 1979_1980insTGAA was a spontaneous mutation.In this paper, the diagnosis and treatment of HPA and clinical and genetic variation characteristics of 23 CdLS cases in China were reviewed, so as to improve the knowledge of doctors about HPA combined with CdLS.

Objective:To investigate the feasibility of MRI measurement for normal fetal aortic arch isthmus diameter and ductus arteriosus diameter between 20 to 36 weeks of gestation and analyze its relationship with gestational age.Methods:This retrospective study enrolled 257 pregnant women with an unclear fetal four-chamber view in prenatal ultrasonography, whose following fetal MRI examination results showed no structural cardiac abnormalities, in Shanghai Children's Medical Center Affiliated to the Medical College of Shanghai Jiaotong University from June 2018 to June 2020. Postnatal echocardiography confirmed cardiac structures were normal in all cases. MRI images were reviewed to measure the diameter of the aortic arch isthmus, defined as the aortic arch isthmus's central diameter, in the transverse section of the aortic arch in steady-state free precession sequence imaging and the diameter of ductus arteriosus near the descending aorta. The average values were calculated after repeating each measurement three times. The 5th, 50th and 95th percentiles and their 95% CI of the aortic arch isthmus diameter and the ductus arteriosus diameter corresponding to different gestational age and the mean value and its 95% CI of the ratio of the aortic arch isthmus diameter to the ductus arteriosus diameter were calculated. Pearson correlation analysis and regression analysis were used to evaluate the relationship of the aortic arch isthmus diameter and the ductus arteriosus diameter with gestational age. Results:The regression equation between the aortic arch isthmus diameter and gestational age was as follows: the aortic arch isthmus diameter (mm) =-2.85+0.22×gestational age (weeks), and there was a positive linear correlation between them ( R2=0.737, P<0.001). The 50th percentile of the aortic arch isthmus diameter was 1.8-3.5 mm at 20-28 weeks and 3.5-5.0 mm at 28-36 weeks. The regression equation between the diameter of ductus arteriosus and gestational age was as follows: the diameter of ductus arteriosus (mm) =-2.17+0.19×gestational age (weeks), and a positive linear correlation between them was revealed ( R2=0.606, P<0.001). The 50th percentile of the diameter of ductus arteriosus was 2.0-3.5 mm at 20-28 weeks and 3.2-4.8 mm at 28-36 weeks. The 95% CI for the ratios of the aortic arch isthmus diameter to the ductus arteriosus diameter at 20, 22, 24, 26, 28, 30, 32, 34 and 36 weeks of gestation were 0.8-1.1, 0.8-1.0, 0.8-1.0, 0.8-1.3, 0.8-1.5, 0.9-1.5, 0.9-1.7, 0.9-1.1 and 1.0-1.3, respectively, and were all close to 1. Conclusions:It is feasible to measure fetal aortic arch isthmus diameter and ductus arteriosus diameter at 20-36 weeks of gestation in MRI, and both measurements have a linear correlation with gestational age.

AIM: To establish the determination for camphor, menthol, synthetic borneol, and methyl salicylate in four kinds of TCM adhesive plasters by GC. METHODS: The internal standard method was employed. Naphthalene, the internal standard, was added to the sample before treatment. The sample solution was prepared by distillation with essential oil collector. The GC system consisted of glass column, 10% PEG 20M as the stationary phase, nitrogen as the carrier gas, column temperature at 130℃, and FID as the detector. RESULTS: Camphor, menthol, synthetic borneol(borneol and isoborneol), and methyl salicylate in 6 lots of samples and naphthalene have been separated well under the chromatographic condition. In the methodology study on Fengshi Zhitong Adhesive Plasters, the average recovery of camphor, menthol, synthetic borneol, and methyl salicylate were 95.54%( RSD =1.6%), 96.90%( RSD =2.2%), 97.30%( RSD =1.4%), and 96.48%( RSD =2.8%), respectively. CONCLUSION: The method is sensitive, accurate and reproducible, and can be used to control the quality of the four kinds of preparations.

Alzheimer Disease ; pathology ; China ; Genes, p53 ; Glial Fibrillary Acidic Protein ; metabolism ; Humans ; Multiple Sclerosis ; pathology ; Nervous System Neoplasms ; classification ; genetics ; metabolism ; pathology