OBJECTIVE:To assess the application value of large dose of naloxone hydrochloride in treating early stage craniocerebral trauma.METHODS:79craniocerebral trauma cases whose GCS scores were5to8scores were enrolled:38(control group)were randomly assigned to receive conventional therapy(dehydrating agent,glucocorticoid,antibacterials,nu?tritional brain cells,and so on),and41(naloxone group)to receive additional naloxone besides the conventional therapy as stated in the control group.Variations on GCS scores,serum?-endorphin(?-EP)level,indexes of respiration and circulation,and safe consciousness time of the2groups after treatment were observed.RESULTS:As compared with the control group,naloxone group had shorter safe consciousness time,lower incidences of respiration failure and circulatory failure,more and faster decrease of serum?-EP level(P

Apolipoprotein A-I (ApoA-I), the main protein component of high-density lipoprotein (HDL), plays a pivotal role in reverse cholesterol transport (RCT). Previous studies indicated a reduction of serum ApoA-I levels in various types of cancer, suggesting ApoA-I as a potential cancer biomarker. Herein, ectopically overexpressed ApoA-I in MDA-MB-231 breast cancer cells was observed to have antitumor effects, inhibiting cell proliferation and migration. Subsequent studies on the mechanism of expression regulation revealed that estradiol (E2)/estrogen receptor α (ERα) signaling activates