1.Primary hypoparathyroidism and non-functioning pituitary adenoma: An incidental coexistence?
Journal of the ASEAN Federation of Endocrine Societies 2014;29(1):86-89
Primary hypoparathyroidism is caused by a group of heterogeneous conditions in which hypocalcemia and hyperphosphatemia occur as a result of deficient parathyroid hormone (PTH) secretion. The most common cause is surgical excision and damage to the parathyroid gland(s). Nonetheless, autoimmune endocrine disorder of primary hypothyroidism has been well-described in polyglandular autoimmune syndromes (PAS).1 Its association with pituitary lesion may be autoimmune lymphocytic hypophysitis as the cause for pituitary disorder. In this report, we encountered a patient with primary hypoparathyroidism who had a non-functioning pituitary tumour. It was confirmed as pituitary adenoma rather than lymphocytic hypophysitis from the histopathological examination. To our knowledge, this is the first reported case of non-functioning pituitary macroadenoma and primary hypoparathyroidism.
Hypopituitarism
;
Autoimmune Hypophysitis
;
DiGeorge Syndrome
2.Rare presentation of right Adrenal Mass: Extramedullary haematopoiesis in a patient with Thalassaemia Intermedia
Poh Shean Wong ; Lit Sin Yong ; Nor Afidah Binti Karim ; Ee Leng Gan ; See Guan Toh ; Noor Lita Binti Adam
Journal of the ASEAN Federation of Endocrine Societies 2021;36(1):80-84
Extramedullary hematopoiesis (EMH) is a rare cause of adrenal mass. We present a 44-year-old woman who has thalassaemia intermedia, referred to Endocrinology clinic for huge adrenal mass. Along with a paraspinal lesion discovered in this patient, the leading diagnosis was EMH. The patient was treated with hypertransfusion and hydroxyurea, which led to a reduction in the size of the right adrenal mass and paraspinal mass. This case highlights the challenges in managing this rare condition. Although EMH is a rare cause of adrenal mass, the diagnosis must be considered in any patient with a history of a congenital hemolytic disorder, to avoid unnecessary surgical procedures.
Hematopoiesis, Extramedullary