The plant Melastoma dodecandrum Lour. is an ingredient used in She medicine that belongs to the Melastomacea family. Its main chemical components include fatty acids, organic acids, polysaccharides, volatile oils, flavonoids, tannins, triterpenes, steroids and other chemical components. Various pharmacological properties of this herbal medicine have been proved, such as anti-oxidation, hypoglycemic, blood lipid, anti-inflammatory and analgesic, hemostasis and coagulation, and antibacterial effects. Clinical studies have shown that it can be used for diseases such as gastrointestinal bleeding, metrorrhagia and diabetes. This article mainly reviews the research progress of the chemical components, pharmacological effects and clinical application of Melastoma dodecandrum, and provides theoretical guidance and practical value for the development, application and clinical research of Melastoma dodecandrum.

OBJECTIVE: To compare the clinical efficacy between scalp acupuncture electrical stimulation and routine scalp acupuncture for motor aphasia in subacute stage of cerebral infarction. METHODS: A total of 54 patients with motor aphasia in subacute stage of cerebral infarction were randomly divided into an observation group (27 cases, 1 case dropped off) and a control group (27 cases, 2 cases dropped off ). Both groups were treated with routine medication and language training. In the observation group, scalp acupuncture was given at bilateral lower 2/5 of the parietal and temporal anterior oblique line and temporal frontline; after the arrival of RESULTS: After treatment, the scores of listening comprehension, retelling, naming, spontaneous conversation and BDAE grade in the two groups were improved compared with those before treatment ( CONCLUSION The scalp acupuncture electrical stimulation could improve cerebral circulation, activate specific functional areas of cerebral cortex, and promote the reconstruction and recovery of brain language function. Its curative effect is better than conventional scalp acupuncture.
Acupuncture Points ; Acupuncture Therapy ; Aphasia, Broca ; Cerebral Infarction/therapy* ; Electric Stimulation ; Humans ; Scalp ; Stroke ; Treatment Outcome

AIM: To investigate the effects of conjunctival approach, lateral approach, skin approach and lateral medial conjunctival approach on visual acuity, tumor residual rate and complications in patients with deep cavernous hemangioma of the orbit.

METHODS: Totally 114 patients with deep cavernous hemangioma of the orbit were divided into group A(30 cases, conjunctival approach), group B(34 cases, translateral approach)and group C(27 cases, transcutaneous)according to the surgical approach. The approach and the D group(23 cases, combined with the medial conjunctival approach via the lateral side), compared the visual acuity improvement effect, tumor residual rate and postoperative complications in the four groups.

RESULTS: There was no difference in visual acuity improvement between the four groups(P=0.918). The residual tumor rates of patients in group A, group B, group C and group D were 0, 2.9%, 3.7%, and 0, respectively. There was no difference in the incidence of postoperative complications between the four groups(P=0.244).

CONCLUSION: According to the indications of deep cavernous hemangioma of the orbit, the reasonable choice of minimally invasive surgery can effectively maintain the normal visual acuity level and the safety is consistent.

Objective: To research the clinical effect of platelet rich plasma combined with Bio-oss artificial bone meal in repairing bone defects around implants. Methods: From January 2015 to January 2017, 70 cases who completed the implant repair in Lishui People's Hospital, and later confirmed the defects around the implant were selected in the research.They were equally divided into observation group and control group according to admission, with 35 cases in each group.The control group was treated with Bio-oss artificial bone powder.The observation group was treated with platelet rich plasma combined with Bio-oss artificial bone powder.The clinical effects of the two groups were compared and analyzed. Results: Before treatment, the probe depth (PD), clinical attachment loss (CAL), plaque index (PI), gingival sulcus hemorrhage index (SBI) of the observation group and the control group were (7.18±1.31)mm, (5.68±0.87)mm, (1.23±0.31), (2.48±0.34) and (7.22±1.28)mm, (5.74±0.83)mm, (1.27±0.33), (2.53±0.36), respectively, which were significantly higher than those after treatment (all P<0.05). Before treatment, the bone mineral density (BMD) levels of the two groups were (35.48±4.58)g/cm³ and (35.74±4.61)g/cm³, respectively, which were significantly lower than those after treatment (all P<0.05). The levels of PD, CAL, PI and SBI in the observation group at 3 months and 6 months after treatment were (4.48±1.01)mm, (4.27±0.53)mm, (0.68±0.21), (1.12±0.13) and (3.43±0.76)mm, (3.58±0.54)mm, (0.38±0.07), (0.41±0.08), respectively, which were significantly lower than those in the control group [(5.19±0.83)mm, (4.83±0.71)mm, (0.89±0.27), (1.46±0.21) and (4.14±0.98)mm, (4.21±0.62)mm, (0.49±0.11), (0.63±0.13)], the differences were statistically significant (t=3.213, 3.739, 3.632, 8.144 and 3.387, 4.533, 4.991, 8.526, P=0.002, 0.000, 0.000, 0.000, 0.001, 0.000, 0.000, 0.000, 0.000, 0.000). The levels of TA anterior temporalis muscle EMG and MA masseter muscle EMG in the two groups at 6 months after treatment were (76.81±15.17)mV, (67.56±14.43)mV, (74.24±13.28)mV, (68.27±13.03)mV, (66.44±13.28)mV, (58.76±13.07)mV, (65.58±11.55)mV, (59.04±10.76)mV, respectively, which were significantly higher than those before treatment [(46.48±11.15) mV, (38.19±13.04) mV, (54.83±12.57) mV, (56.48±13.13) mV and (45.71±10.98) mV, (38.23±13.11)mV, (55.14±12.69) mV, (56.61±13.08) mV] (all P<0.05). After treatment, the ICP-HB, ICMAP-MC, TA, EMG levels in the observation group were significantly higher than those in the control group, the differences were statistically significant (t=3.042, 2.674, 2.911, 2.994, P=0.003, 0.009, 0.004 and 0.003). Conclusion The effect of rich plate plasma combined with Bio-oss artificial bone powder on the repair of bone defect around the implant is significant.The platelet rich plasma can speed up and improve the repair speed and repair quality of bone defect around the implant, so that the therapeutic effect of implant repair can be maintained for a long time.

OBJECTIVE To investigate the components and metabolites of leaves of Cyclocarya paliurus in rats plasma. METHODS UHPLC-Q/TOF-MS method was applied to identify the components and metabolites of rat plasma. The prototype components and metabolites were analyzed in rats plasma of leaves of Cyclocarya paliurus water extract after intragastric administration by comparing the chromatograms of Cyclocarya paliurus, blank serum and drug-containing serum. RESULTS A total of 15 compounds including 6 prototype components and 9 metabolites were identified. The main prototype components in blood were caffeylquinic acid, flavonoids and saponins, and the metabolic pathways were methylation and hydroxylation. CONCLUSION This experiment showes that the prototype components absorbed into blood may be the potential bioactive components in leaves of Cyclocarya paliurus, providing a scientific basis for clarifying its material basis in pharmacodynamics.

OBJECTIVE To prepare vancomycin hydrochloride （VH）-loaded polydopamine （PDA） nanoparticles （VH@PDA nanoparticles）， and study their antimicrobial effect in combination with photothermal therapy. METHODS Using PDA as the carrier， VH was loaded to prepare VH@PDA nanoparticles （PDA nanoparticles were prepared using the same method）. The nanoparticles were characterized with laser particle size analyzer， transmission electron microscope， and UV visible absorption spectrometer； the drug loading capacity and encapsulation efficiency of the nanoparticles were determined. The near-infrared laser irradiation was adopted to determine their photothermal ability. Taking Staphylococcus aureus as the research object， the bactericidal properties of the nanoparticles in combination with photothermal therapy in vitro were clarified through plate colony coating method， live/dead staining analysis， crystal violet staining. Using L929 cells as the research object， the effects of VH@PDA nanoparticles at different mass concentrations （0， 3.125， 6.25， 12.5， 25， 50 and 100 μg/mL） on cell viability were investigated to assess their biocompatibility. RESULTS VH@PDA nanoparticles were successfully loaded with VH， exhibiting uniform particle size （approximately 300 nm）， distinct pore size， and a spherical structure. The drug loading capacity was 11.34%， the encapsulation efficiency was 32.00%， the photothermal conversion efficiency reached 23.55%， and they demonstrated stable photothermal performance. The antibacterial effect results of the combined photothermal therapy demonstrated that without near- infrared laser irradiation， the antibacterial effects of VH， PDA nanoparticles， and VH@PDA nanoparticles were not significant. However， when subjected to near-infrared laser irradiation， VH@PDA nanoparticles exhibited a pronounced antibacterial effect. The results of the cell experiments revealed that after treatment with VH@PDA nanoparticles at various mass concentrations， the cell viability rates remained above 80%. CONCLUSIONS VH@PDA nanoparticles are successfully prepared， which exhibit stable photothermal properties， significant antibacterial effects when combined with photothermal therapy， and good biocompatibility.

The monosaccharide composition and the structure of polysaccharide from Pichia fermentans were analyzed. The yeast cells were broken with ultrasonic disruption and the crude polysaccharide was precipitated by addition of ethanol. Then, the crude polysaccharide was separated by diethylaminoethyl(DEAE) cellulose column separation and an acquisition of uniform water-soluble polysaccharide yeast polysaccharides 5(YP5) was obtained. The results of gas chromatographic analysis indicated that the glycosyl was made of rhamnose, arabinose, xylose, mannose, glucose and galactose, whose molar ratio was 9.51∶ 1.33∶ 2.31∶ 0.94∶ 84.93∶0.96, respectively. The molecular weight of polysaccharides YP5 was 8.3×10~4 measured by Ubbelohde viscosity method. Combination of IR and ~1H NMR analysis showed that the YP5 owned characteristic infrared absorption peaks of polysaccharide and contained amino groups. The β-D-glucan was main glucosidic linkage of polysaccharides PY5.

This study was purposed to explore the significance of tissue factor (TF), tissue factor pathway inhibitor (IFPI) and interleukin-1beta (IL-1beta) in the evaluation of development, curative effect and prognosis of AL patients. ELISA was used to detect the levels of TF, TFPI and IL-1beta in plasma of 20 healthy individuals and 24 newly diagnosed AL patients. All the three indications of patients were measured in different stages including pre-chemotherapy phase, at 72 hours after chemotherapy, complete remission phase. The results showed that as compared with normal control, levels of TF, TFPI and IL-1beta in plasma of AL patients during pre-chemotherapy phase were higher (p < 0.01); as compared with pre-chemotherapy phase, levels of TF, IL-1beta were elevated at 72 hours after -chemotherapy (p < 0.05). However, the levels of TFPI was much lower than that of 72 hours after chemotherapy (p < 0.01). 16 out of 24 patients got complete remission, there was no difference of TF, TFPI and IL-1beta between complete remission group and normal control group. It is concluded that the levels of TF, TFPI and IL-1beta in plasma can be used as the indicators for understanding clinical features, evaluating disease status and predicting prognosis in acute leukemia patients.
Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; blood ; Child ; Female ; Humans ; Interleukin-1beta ; blood ; Leukemia ; blood ; Lipoproteins ; blood ; Male ; Middle Aged ; Thromboplastin ; metabolism ; Young Adult

Field surveys and literatures show that Polygonati Rhizome (Huangjing) was firstly recorded in Shen Nong&s Herbal Classic, and widely used as a medicinal and edible plant. It has a long history of cultivation, and the researches on chemistry have made some progress. The future development is prospected on health market. But the Polygonati Rhizome industry has faced a lot of problems, including the resource depletion, unstable quality, low-tech in cultivation and germplasm confusion, unclear of functional composition, decentralized, small scaled and primary processing products. The suggestion for sustainable development are listed below. First, the relevant researches should focused on material basis and biological mechanism of core effects. To speed up the selection and breeding of improved varieties, ensure the supply of high-quality seedlings and eliminate the unauthentic species are the most important measures. Secondly, to strengthen the conservation and rational use of wild resources, break through the key technologies of high-quality artificial cultivation on light regulation, site control, density control and precision harvesting are also very important. Thirdly, to reveal the toxicity-reducing-and-efficacy-enhancing mechanism of processing, optimize the parameters and setup the standard operating procedure are indispensable. Fourthly, that full advantage of the root, leaf, flower and fruit resources should be strengthened for enlarged health products based on the development of exact functional factors. Above all, Polygonati Rhizome could be a growing market in the future driven by the technological innovation, cultural creativity, integration of three industries, brand strategy and internet+technique.

COVID-19 ; Humans ; Olfaction Disorders ; SARS-CoV-2 ; Smell