1.Yimucao Injection combined with oxytocin in preventing postpartum hemorrhage after cesarean section
Drug Evaluation Research 2017;40(6):820-823
Objective To investigate the clinical effect of Yimucao Injection combined with oxytocin in preventing postpartum hemorrhage after cesarean section.Methods 500 cases of pregnant women with cesarean section who were treated in Leshan Maternal and Child Health Hospital from January 2011 to June 2016 were divided into two groups randomly.The patients in the control group were only given oxytocin,while the patients in the observation group were given Yimucao Injection combined with oxytocin.To observe the clinical effect of the two groups,the amount of intraoperative hemorrhage volume,postoperative 2h bleeding,postoperative 24 h bleeding volume,the duration time of postpartum hemorrhage and hospitalization time,and the occurrence of adverse reactions in the two groups.Results The total effective rate of observation group was 90.40% (226/250),which was significantly higher than the control group 73.20 (183/250) (P < 0.05).Compared with the control group,the amounts of blood loss,2 h postoperative bleeding volume and 24 h postoperative bleeding volum in observation group were significantly decreased (P < 0.05).The duration time of postpartum hemorrhage and hospitalization time in observation group were significantly shorter than the control group (P < 0.05).24 h hemoglobin and red blood cell of the observation group were significantly lower than that of the control group (P < 0.05).The incidence of adverse reactions was significantly lower than that of the control group (P < 0.05).Conclusion Yimucao Injection combined with oxytocin can effectively reduce the amount of bleeding,shorten the time of bleeding and hospitalization time,safe and effective,which is worthy of clinical application.
2.ANALYSIS OF DEVELOPING STRATEGY ON THE GRADE B CLASS 3 HOSPITAL UNDER THE BACKGROUND OF HIERARCHICAL DIAGNOSIS AND TREATMENT POLICIES
Modern Hospital 2015;(10):81-82
The implementation of hierarchical diagnosis and treatment policies will have a significant impact on the entire health care system .From the view the implementation of the policies of provinces now , tertiary hospital has been defined as a whole , and did not consider differences between grade b class 3 hospital and grade a class 3 hospital.Based on the overview of the policies , this article analyzed the external environment of the grade b class 3 hospital facing from strengths , weaknesses , opportunities and threats by using SWOT Analysis .Then propose counter-measures and suggestions of enhancing its ability and competitiveness to respond to the policies .
3.Analysis of K-ras gene mutation in 358 cases of lung cancer
International Journal of Laboratory Medicine 2016;(3):321-323
Objective To analyze the mutation situation of K‐ras gene in 358 cases of lung cancer to provide the guidance for the personalized therapy of lung cancer .Methods The nested and low denatured temperature compound PCR (COLD‐PCR) method was used to analyze the K‐ras mutations situation in 358 patients with lung cancer .Results In 358 lung cancer patients ,the total mutation frequency of K‐ras gene was 8 .10% .The mutation rates were 2 .13% in 94 plasma samples ,9 .60% in 250 tumor tissue samples and 7 .14% in 14 pleural and ascites samples .The mutation types included G12C ,G12D ,G12A ,G12V ,G13D and Q61H ,the mutation rate had no statistical difference among 3 kinds of samples (P= 0 .064 8) ;the mutation rate was 6 .96% in male patients and 8 .59% in female patients ,the difference was not statistically significant (P= 0 .574 0) ;the mutation rates were 4 .76% in the patients aged 30 - < 45 years old ,5 .34% in the patients aged 45 - < 60 years old and 9 .22% in the patients aged ≥ 60 years old , the differences were not statistically significant (P = 0 .250 3) .Conclusion The mutation types of K‐ras gene are mainly G12C , G12D ,G12V and G13D .The mutation rate of K‐ras gene has no significant differences among different types of sample ,different genders and different ages .
4.Situation and countermeasures of the educational inspection for colleges and universities
Liqin FU ; Jicheng LI ; Xiaoming ZHANG
Chinese Journal of Medical Education Research 2006;0(11):-
This study analyzes the reason and situation of the educational inspection for colleges and universities.The author suggests the five points to solve these problems and provide countermeasures for improving the educational inspection.
5.Effects of modified radical mastectomy combined with chemotherapy on complications and quality of life in patients with breast cancer
Quanyuan LI ; Liqin YAN ; Jian WEI
Journal of Clinical Surgery 2015;(2):132-134
Objective To explore the effects of modified radical surgery combined with chemo-therapy on postoperative complications and quality of life in breast cancer patients.Methods The clinical data of 175 patients with early breast cancer were retrospective analyzed.According to the different ways of surgical treatment,patients were divided into the control group(n =100)and the study group(n =75).In the study group,patients received modified radical mastectomy,and preoperative and postoperative chemo-therapy as adjuvant therapy.In the control group,patients received traditional standard radical surgery.The follow-up ranged from 1 to 3 years.Recurrence,mortality,postoperative complications,and quality of life were compared between the two groups.Results There were no significant differences in local recurrence (6.7% vs 6%)and axillary lymph node recurrence (2.7% vs 3%),distant metastasis (10.7% vs 11%),and 5-year survival rate(92% vs 91%)between the study group and control group(P >0.05).In the study group,the incidence of postoperative complications was significantly lower(6.7% vs 42%), while its score on quality of life significantly improved(P <0.05).Conclusion For early breast cancer, modified radical mastectomy combined with chemotherapy has similar effects as the standard radical mas-tectomy.It has obvious advantages in reducing complications and improving the quality of life,which is worthy of being spread clinically.
6.Hepatoprotective effect of Paecilomyces tenuipes polysaccharides on carbon tetrachloride-induced liver injury
Liqin JIN ; Baojian LI ; Jianxin L
Chinese Journal of Pathophysiology 1999;0(09):-
AIM: To investigate the protective effect of crude Paecilomyces tenuipes polysaccharides(cPtPs) and Paecilomyces tenuipes polysaccharides(PtPs) in a rat model of acute hepatic necrosis induced by carbon tetrachloride(CCl4).METHODS: Wistar rats were divided into four groups(control group,CCl4 group,cPtPs+CCl4 group and PtPs +CCl4 group),the four groups were given intragastrically with normal saline,cPtPs and PtPs for 15 d,respectively.In the last two days,these groups except control group were injected peritoneally with CCl4.Serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),direct bilirubin(DBIL) and indirect bilirubin(IBIL) were detected by automatic biochemistry analyzer.Pathological changes of hepatic tissue were assessed by hematoxylin-eosine(HE) staining.The levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in liver homogenate were analyzed using xanthinoxidase and thio-barbituric acid,respectively.The concentration of Ca2+ in hepatocyte mitochondria was determined by colorimetric method.The expression of ?-smooth muscle actin(?-SMA) was examined in hepatic tissue by immunohistochemical method.RESULTS: Compared with control group,serum levels of ALT,AST,TBIL,DBIL and IBIL in CCl4 group increased significantly,denaturation and necrosis implicated to the whole hepatic lobules.Compared with CCl4 group,serum levels of ALT,AST,TBIL,DBIL and IBIL in PtPs +CCl4 group decreased significantly,denaturation and necrosis located in the third region of hepatic lobules,the level of SOD increased and MDA decreased(P
7.Implementation and development of independent check in radiotherapy
Jiuling SHEN ; Guangjun LI ; Liqin LI ; Fubo LIU ; Sen BAI
Chinese Journal of Radiation Oncology 2017;26(6):715-718
Independent check is one of the key measures of quality control (QC) in radiotherapy and is essential for the assurance of radiotherapy accuracy.In recent years,with the application of computer-aided system,the automaticity of independent check,as well as its accuracy and efficiency,increases.Meanwhile,QC has evolved from a device-centered to a process-centered program.Therefore,independent check has been increasingly systematic and specific.This review gives a brief summary of the implementation and development of independent check.
8.Research progress in electronic portal imaging device-based in vivo dosimetry verification
Liqin LI ; Guangjun LI ; Jiuling SHEN ; Sen BAI
Chinese Journal of Radiation Oncology 2017;26(7):833-837
In vivo dosimetry (IVD) is currently the most direct and effective means of quality assurance.The electronic portal imaging device (EPID) has been widely used for IVD verification owing to its favorable dosimetric properties.In recent years,an increasing number of EPID-based IVD studies have emerged around the world.The purpose of this paper is to give an overview of the present progress in EPID-based IVD studies,and to provide a reference for the subsequent application of EPID in IVD.
9.Research on the Conformance Test of Health Information Standard in Canada
Yazi LI ; Liqin XIE ; Guolei LI ; Aiyun ZHANG
Journal of Medical Informatics 2015;(10):8-13
〔Abstract〕 Based on the retrieval sources of the official website of Inforway in Canada , Tongfang Knowledge Network and Internet re-sources, by investigating the conformance test of health informatization and health standards conducted by Inforway in Canada , the paper makes a comprehensive analysis of the conformance test of health information standards in Canada from 4 aspects, namely the certification subject, certification object , certification standard , certification process .It aims to provide references for the conformance test of health information standards in China .
10.Practice of strengthening private hospitals governance in Hubei province
Chengcheng YIN ; Song LI ; Wenbin ZHANG ; Lanxiang YU ; Liqin LI
Chinese Journal of Hospital Administration 2013;29(9):646-648
Better governance of private hospitals is key to deepening the health reform.In view of the present development of private hospitals in Hubei province,this paper expounded the characteristics development of private hospitals and the governance of specific measures in the province and analyzed the defects found in the legal system and mechanism.The authors also raised such recommendations as perfecting the legal system and improving the mechanism of information disclosure and evaluation.