SpA,one of the important virulence factors of Staphylococcus aureus,can impede phagocytosis,induce apoptosis of B cells,initiate staphylococcal pneumonia and endocarditis,et al.The expression of Spa gene is regulated by a very subtle and complicated systematic web.With the mechanism of the virulence and the gene regulation of Spa were known more and more clearly,New methods of the infection by Staphylococcus aureus were would be found.

Obiective To observe the clinical effect of treating upper respiratory infection induced coughing with atomizated ioint of compound liquorice oral solution and ipratropium bromide.Methods 69 cases of respiratory tract infection induced coughing were randomly recruited into A,B,and C group.Group A was treated with atomizated joint of compound liquorice oral solution and ipratropium bromide;Group C was treated with azithromycin and levofloxaein;Group B was treated with the combined therapy of Group A and Group C.Clinical effects and side effects were observed after the treatment.Results Symptom scores of cough in group A and group B were lower than those in group C.The difference was statistically significant(P＜0.05).Dry mouth and throat complaints disappeared in group A and group A and group B after the treatment.Conclusion Tomizated ioint of compound liquorice oral solution and ipratropium bromide had good therapeutic effects in treating cough induced by upper respiratory infection.

Objective: To investigate the clinical value of a micro-array for multi-tumor marker detection (abbreviate C-12 system in the following) in four kinds of tumors (lung, liver, pancreas/colon and stomach cancers). Methods:30 lung cancer?19 liver cancer?24 pancreas/colon?22 stomach cancer and 173 non-tumor patients' serum were detected by C-12 system, and the results were analyzed by ROC curve.Results:There is no difference in the positive rate of single TM between C-12 system and the previously reports; The positive rate and the mean positive value of tumor patients were both obviously higher than that of non-tumor patients (P

Obj ective To explore changes of plasma NT-proBNP and inflamatory cytokines levels before and after treatment for preeclampsia.Methods The levels of NT-proBNP(with fluore-scent immunoassay)and infammatory cytokines(IL-6 ,hs-CRP and TNF-αwith high-sensitive en-zyme immunoassay and radio immunoassay)in plasma were detected in 93 patients with preeclamp-sia (including 45 cases of light pre-eclampsia and 48 cases of severe pre-eclampsia),and 42 normal people were collected and detected for contrastive analysis.Results Before treatment,the plasma NT-proBNP and inflammatory cytokines (IL-6 ,hs-CRP and TNF-α)levels in 93 patients with preeclampsia were significantly higher than those in 42 normal people (P<0 .0 1 ).The plasma NT-proBNP,IL-6,hs-CRP and TNF-αlevels increased with increasing degree of preeclampsia.After treatment,the levels of NT-proBNP,IL-6,hs-CRP and TNF-αin 45 patients with light pre-eclampsia reached to normal level (P>0 .05 ).Though the plasma IL-6 level reached to normal lev-el,the levels of NT-proBNP,hs-CRP and TNF-αin 48 patients with severe pre-eclampsia were sig-nificantly higher than those in 42 normal people (P<0 .05 ).Conclusion The plasma NT-proBNP and inflammatory cytokines participate in pathogenesis process of preeclampsia,and these two indi-cators are effective monitoring index for the early treatment of preeclampsia.

Obj ective To explore changes of plasma NT-proBNP and inflamatory cytokines levels before and after treatment for preeclampsia.Methods The levels of NT-proBNP(with fluore-scent immunoassay)and infammatory cytokines(IL-6 ,hs-CRP and TNF-αwith high-sensitive en-zyme immunoassay and radio immunoassay)in plasma were detected in 93 patients with preeclamp-sia (including 45 cases of light pre-eclampsia and 48 cases of severe pre-eclampsia),and 42 normal people were collected and detected for contrastive analysis.Results Before treatment,the plasma NT-proBNP and inflammatory cytokines (IL-6 ,hs-CRP and TNF-α)levels in 93 patients with preeclampsia were significantly higher than those in 42 normal people (P<0 .0 1 ).The plasma NT-proBNP,IL-6,hs-CRP and TNF-αlevels increased with increasing degree of preeclampsia.After treatment,the levels of NT-proBNP,IL-6,hs-CRP and TNF-αin 45 patients with light pre-eclampsia reached to normal level (P>0 .05 ).Though the plasma IL-6 level reached to normal lev-el,the levels of NT-proBNP,hs-CRP and TNF-αin 48 patients with severe pre-eclampsia were sig-nificantly higher than those in 42 normal people (P<0 .05 ).Conclusion The plasma NT-proBNP and inflammatory cytokines participate in pathogenesis process of preeclampsia,and these two indi-cators are effective monitoring index for the early treatment of preeclampsia.

Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.