1.Influence of family intervention on the medication compliance of patients with depression
Chinese Journal of Practical Nursing 2008;24(17):62-63
Objective We discussed the influence of family intervention on the medication compliance and treatment effect of patients with depression. Methods 60 patients with depression were divided into the test group and the control group with 30 cases in each group. The control group adopted routine treatment. The test group was given strengthened family intervention based upon routine treatment. The medication compliance was evaluated at the first day of visit and 6 months after treatment. The Hamilton depression scale (HAMD) was used to estimate the depression condition of these patients. The treatment effect was compared between the two groups. Results The medication compliance of the test group was better than that of the control group (X2=4.29, P<0.05). The HAMD score of the test group was lower than that of the control group (P<0.01). Conclusion Family intervention had positive effect on the medication compliance and treatment effect of patients with depression.
2.Influence of Taoist Education on Subjective Well-being of Elderly
Minjuan ZHOU ; Liqi YAO ; Jimei XU
Chinese Mental Health Journal 1989;0(03):-
Objective: To investigate the influence of Taoist education on subjective well-being of elderly Method: 105 elderly participated the Taoist education for 3 months were assessed with PGC (Philadelphia geriatric confidence) and SCL-90 before and after the education Other information, such as status of marriage, family relationship, self-reported health state, were also collected Results: The average scores of anxiety, phobia, somatization and depression in SCL-90 were higher in elderly than Chinese norm (P
3.Role of Macrophage Activation and Polarization in Myocardial Fibrosis and Intervention of Traditional Chinese Medicine
Kunpeng YAO ; Huzhi CAI ; Xiang ZHAO ; Ke GONG ; Chuning TIAN ; Yuntao LUO ; Liqi PENG ; Guangyang OU ; Qingyang CHEN ; Xinyu CHEN
Chinese Journal of Experimental Traditional Medical Formulae 2024;30(9):272-282
Myocardial fibrosis (MF) is a common pathological manifestation of various heart diseases. Due to the non-renewable nature of myocardial cells, the occurrence of MF represents irreversible damage to the myocardium. Previous studies have suggested that fibroblast-mediated collagen deposition is the main mechanism of MF. Recent studies have found that there is an immune regulation mechanism in the heart itself, and macrophage activation/polarization plays an important role in MF. With the deepening of traditional Chinese medicine research, scholars have found that traditional Chinese medicine can interfere with MF by regulating the renin-angiotensin-aldosterone system (RAAS) system and the inflammatory process, repairing the extracellular matrix, managing oxidative stress, and maintaining the balance of autophagy. This process is closely related to the activation and M1/M2 polarization of macrophages. Throughout the MF process, macrophage activation is beneficial, but excessive activation will be harmful. In the early stage of MF, appropriate M1 macrophage polarization is conducive to activating immunity and removing harmful substances. In the middle and late stages of MF, appropriate M2 macrophage polarization is conducive to remodeling the damaged myocardium. If macrophage activation is excessive/insufficient, or the balance of M1/M2 macrophage polarization is broken, the effect changes from improvement to destruction. Traditional Chinese medicines that regulate the activation/polarization of macrophages have the effects of replenishing Qi and nourishing Yin, as well as regulating Qi and activating blood, but there are also some heat-clearing, dampness-drying, and detoxification products. Therefore, the occurrence of MF may be caused by Qi and Yin deficiency, damp heat accumulation, and Qi stagnation and blood stasis. By summarizing the biological processes involved in macrophage activation/polarization in MF, this paper expounded on the research progress of traditional Chinese medicine in regulating macrophage activation and M1/M2 polarization from different angles to improve MF, so as to provide a reference for the treatment of MF with traditional Chinese medicine.