Objective To study the clinical application of low molecular weight heparin combined with psychological intervention in the prevention of deep venous thrombosis after lower limb fracture surgery.Methods 100 patients with lower limb fracture treated in our hospital from January 2013 to December 2016 were selected as the research object in the course of the study, and randomly divided into control group and experimental group, with 50 cases in each group,.The patients in control group were treated with routine lower limb physical pressure to prevent deep venous thrombosis after lower limb fracture.The patients in the experimental group were treated with low molecular heparin combined with psychological intervention to prevent deep vein thrombosis after lower limb fracture.Comparative analysis of patients with prothrombin time and platelet and the experimental group and the control of activated partial thromboplastin time index.Results After different treatment, the platelet index of the experimental group was(189.23±36.23)×109 /L, significantly better than that of the control group(264.34±39.56)×109/L,the difference was statistically significant(P<0.05).After treatment, the patients in the experimental group the activated partial thromboplastin time and prothrombin time index respectively(35.62±4.23)s and(16.12±2.19)s, significantly better than the control group, the difference was statistically significant(P<0.05).Conclusion low molecular weight heparin combined with application of psychological intervention in prevention of deep venous thrombosis after lower limb fracture surgery, can improve clinical curative effect on prevention of deep vein thrombosis in a large extent, improve blood hypercoagulable state of patients after surgery, with further clinical promotion and application significance.

Objective To search the status quo of students'thanatopsis in order to push focused education on terminal care to the nursing major students.Metheds To distribute home-made questionnaire to 268 nursing students.Results students who cannot talk about death normally account for 21.3 percent;who never considered death or unnecessary to consider death account for 12.9 percent of the total;who considered a lot account for 10 percent;who cannot handle terminally ill account for 74.3 percent;and who prefer self-suicide when suffered defeat account for 4.9 percent.Conclusion Nursing students have insufficient ideas of death,and they need to think deeply about the meaning of death and to nurture a positive outlook on death in order to get a correct terminal care education.

Objective:To investigate the efficacy of montelukast in the treatment of children with asthma and its influence on the serum levels of metalloprotease-9 (MMP-9) and metal protease inhibitor-1 (TIMP-1).Methods:Totally 90 cases of asthma children were selected and divided into the control group and the observation group with 45 ones in each .The control group was treated with the conventional symptomatic treatment , and the observation group was treated with montelukast chewable tablets additionally , and the treatment course was 8w.The effectiveness adverse reactions were compared between the groups , and the lung function indices and the changes of MMP-9 and TIMP-1 levels of the two groups were compared as well .Results: The total effective rate of the observation group (93.33%) was significantly better than that of the control group (P<0.05).After the treatment, the levels of FEV1 and PEF were significantly higher than those before the treatment in the two groups , the levels of MMP-9 and TIMP-1 were notably lower than those before the treatment in both groups , and the changes in the observation group were more significant than those in the control group (P<0.05).There were no adverse drug reactions in both groups .Conclusion:Montelukast combined with the conventional therapy can down-regulate the serum levels of MMP-9 and TIMP-1 and inhibit airway remodeling resulting in improved curative effect with high safety.

OBJECTIVE To explore the prevention mesures of hospital infection in aged patients with long-term central vein catheterization.METHODS The clinical data of 26 aged patients with long-term central vein catheterization from Mar 2005 to Oct 2006 were analyzed retrospectively.RESULTS Among 26 aged patients with long-term central vein catheterization,no related hospital infection occurred with average 7 d hospitalization.Swelling in upper extremities was observed in 5 patients.CONCLUSIONS The mesures,such as aseptic procedure for changing transfusion device periodically and using effective filter can effectively prevent the infection.

Objective To observe the clinical efficacy of Bushen-Yiqi-Huayu capsule in the treatment of vascular dementia.Methods 58 cases who diagnosed with vascular dementia,Chinese Traditional Medicine fine for the gas deficiency and blood stasis,Tanzu patients were randomly divided into two groups:observation group with 30 patients(oral Bushen-Yiqi-Huayu capsule); control group with 28 cases (oral Piracetam tablet),Treatment course three-months. Results The total effective rate was 86.7 percent,compared with the control group (total effective rate 60.8%), and the difference was significant (P

Objective:To observe the effects of osteoprotegerin on osteoclasts in the occlusal tissue during tooth eruption in dog and analyze the mechanism. Methods: Six 7-day-old brood dogs were divided randomly to control and osteoprotegerin groups. The dogs in osteoprotegerin group were injected with osteoprotegerin for 3 days 1.5 mg/(kg?d). 5 days after injection the dogs were sacrificed and mandible were taken out for paraffin slice. The number of the osteoclasts in the occlusal tissue up the third mandibular premolar was detected by tartrate-resistance acid phosphatase(TRAP) staining. Immunohistochemistry was used to examine the expressions of RANKL. Results: The number of osteoclasts in osteoprotegerin group was less than that in the control group (P

Objective To investigate the expression of surfactant protein A(SP-A)in adenocarcinoma and squamous cell carcinoma of lung and its clinical significance.Methods The expression of SP-A was determined by immunohistochemical assay (EnVision) in 27 cases of adenocarcinoma,15 cases of squamous cell carcinoma of lung.Then the association of SP-A expression with clinicopathological parameters was analyzed.Results The expression rate of SP-A was significantly higher in adenocarcinoma of lung than that in squamous cell carcinoma of lung(51.85% vs 6.67%,P<0.01).The expression rate of SP-A in papillary adenocarcinoma,bronchioloalveolar carcinoma,acinar adenocarcinoma and musinous adenocarcinoma of lung was respectively 85.71%,50%,40%and 25%.There was no correlation between the expression of SP-A and gender,age,tumor size and lymph node metastasia.Conclusion The expression of SP-A may be associated with histological types of the lung carcinoma,which may be used as important marker in differential diagnosis of adenocarcinoma and squamous cell carcinoma of lung.

Since the complain center of our hospital was founded in 2011, innovated the philosophy of “com-plain is gold”.It transformed mentality of the leaderships and employees to treat complaints fundamentally .Complain management was regarded as a strategic tool for the hospital to self -improve;Complain was regarded “the third eye”of recognizing the hospital management blind spots or service failure .At the same time, our hospital takes it as an im-portant means to construct the harmonious doctor -patient relationship sincerely .In the past three years , under the guidance of new ideas , our hospital has been innovating the complaint handling mechanism and improving work processes .And we have obtained better result in complaints management under the effort of all the staff .

Objective To investigate the efficacy and safety of HCPT combined with 5-fluorouracil(5-Fu) in treatment of bladder cancer .Methods Selected 92 patients with advanced bladder cancer in our hospi-tal from February 2011 to August 2015 , equally divided into observation group and control group of 46 patients based on the random number table ,the control group were received 5-Fu intravesical chemotherapy ,The obser-vation group were given the HCPT combined with 5-Fu chemotherapy ,the chemotherapy infusion were once a week,continuous perfusion were observed for 3 months.Results The response rates in the observation group was 95.7%and the control group was 76.1%,the observation group were significantly higher than the control group (P<0.05).The occurrence of bladder irritation adverse reaction ,blood abnormalities,liver and kidney dysfunc-tion,bone marrow suppression in the observation group during chemotherapy compared with the control group were no significant difference(P>0.05),all adverse reactions after symptomatic treatment were improved .All patients were followed up for 1 year,The mortality and recurrence rates in the observation group were 8.7%and 4.3%re-spectively,while the control group were 30.4%and 17.4%,the mortality and recurrence rates of the observation group were significantly lower than the control group (P<0.05).Conclusion HCPT combined with 5 -Fu chemotherapy for bladder cancer has strong anti -cancer effect and without increase the incidence of adverse re-actions,it can promote the improvement of the long -term prognosis,so it is a safe and effective topical bladder chemotherapy drugs .