OBJECTIVE:To study the stability of Ondansetron hydrochloride glucose injection(OHGI).METHODS:The contents of Ondansetron hydrochloride and its related substances were determined with HPLC.The stability of the samples were tested by high-light exposure,accelerating experiment and room temperature storage.RESULTS:After exposure to high light,the content in OHGI slightly decreased but on other experiments,it was rather stable.CONCLUSION:This injection should be kept away from high light and may be stored for2years at room temperature.

Objective:To investigate the effect of liver ultrasonography and the security to rabbits with hydrogen peroxide(H 2O 2) affused by rectum.Methods:48 rabbits were divided into 4 groups according to different H 2O 2 concentrations,and each group was divided into 4 groups according to different H 2O 2 dosages. Each rabbit was affused with H 2O 2 by rectum,then the effect of liver ultrasonography was observed,and the damages to the tissues of rabbits were pathologically checked.Results:The liver structure could be clearly developed with 1% H 2O 2 10ml affused,and the liver gray value increased with the H 2O 2 concentration increased.The time from affusion to develop was shortened and the duration of high echo was prolonged.But at same H 2O 2 concentration,the time to develop was not significantly different with the H 2O 2 dosage increased,and the high echo was decreased more slowly.The average survival time of rabbits was significantly negatively correlated to the H 2O 2 concentration(?=-0.99),while the damage degree was significantly positively correlated (?=+0.99).Conclusion:H 2O 2 affusion can induce damage to tissues and microcirculation,while produce better liver ultrasound image,so it is important to chose suitable H 2O 2 concentration and dosage,to extend its clinical application.

Objective:To study the mental health status of middle school students in Three-Gorges area of Chongqing in order to provide theory support for mental health education. Methods:1 014 middle school students in Three-Gorges area were tested by SCL-90. Results:The occurrent rate of mental problems with students was 19.8%,of which the first three factors were hostility,compulsiveness and interpersonal sensitivity. Girls’ overall score and mean scores of interpersonal sensitivity, depression,anxiety and phobic anxiety were significantly higher than boys’. The overall score and factor mean scores of senior high school students were significantly higher than those of junior high school students’ except hostility and phobic anxiety factors. The mean scores of interpersonal sensitivity,hostility and phobic anxiety factors were significantly higher than the counterparts in the norms of middle school students,while the mean scores of somatization and anxiety factors were significantly lower than the counterpart in the norms of middle school students. Conclusion:The mental health status of middle school students in Three-Gorges area of Chongqing is poor,and mental health education should be enhanced by all of us.

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After a description of the concept and characteristics of metaliteracy, the main institutions shouldering the task of metaliteracy education were summarized, including government and fund organizations, faculties, scien-tific research office, and teaching group. Of these institutions, library plays a major role in metaliteracy education since it is not only the main driving force of metaliteracy education and the institution to make,file and maintain the resources for metaliteracy education, but also is the organizer, coordinator and manager of metaliteracy teachers.

Objective To explore the clinical efficacy of cetuximab combined FOLFOX chemotherapy on colon and colorectal cancer.Methods Forty patients with colon and colorectal cancer were randomly divided into observation group and control group,and 20 cases for each group.Patients in control group were treated with oxaliplatin + leucovorin + 5-fluorouracil,and in the observation group were given cetuximab (the first does was 400 mg/m2 at the first week,then the second week and follow weeks was 250 mg/m2 1 time/week for 6 week) plus the treatment as control group.The clinical efficacy,adverse effect and 1-year survival in the two groups were recorded.Results The total effective rate and clinical benefit rate in observation group were 60％ (12/20)and 85％ (17/20) respectively,which significantly higher than the control group (30％ (6/20) and 65 ％ (13/ 20),x2 =18.18,10.67,P ＜ 0.05).Skin rash rate in observation group was 55％ (11/20),which was significantly higher than that of control group (15％ (3/20),x2 =35.16,P ＜0.05).Half-year survival rate and 1-year survival rate of patients in observation group were 75％ (15/20) and 45％ (9/20) respectively,significantly higher than the control group (50％ (10/20) and 25％ (5/20),x2 =13.33,8.791,P ＜ 0.05)~ Conclusion Treatment scheme of Cetuximab combined FOLFOX chemotherapy is proved to be an effect of treating advanced colon and colorectal and be with the low adverse effect.

Autonomic nervous system(ANS) activity plays an important role in the pathogenesis of cardiovascular disease,including organic cardiovascular disease(such as hypertension,coronary artery disease,etc) and functional cardiovascular disease (such as vasovagal syncope,postural orthostatic tachycardia syndrome,etc).Many methods was used to evaluate ANS function.Heart rate variability is a widely accepted method to assess cardiac autonomic nerve function.Autonomic nervous affected cardiac action potential and let electrocardiogram changes.Through the sympathetic and parasympathetic neurotransmitters which acting on the corresponding receptors.Electrocardiogram changes reflects autonomic nervous function.Present researches suggest that electrocardiogram has an important significance in the evaluation of autonomic nerve function in functional cardiovascular disease.

OBJECTIVE:To put forward suggestions for the legal regulation on the financial conflict of interest of researchers in drug clinical trials.METHODS:The definition and harm of the financial conflict of interest of the researchers in clinical trials were analyzed,and the legal measures of FDA on regulating and controlling the financial conflict of interest of the researchers were evaluated.RESULTS & CONCLUSIONS:The Chinese legislature should draw useful legal experiences from USA to establish suitable legal measures to regulate and control the financial conflict of interest of researchers in clinical trials,clarify the definition of the financial interest of researchers,require the applicant for clinical trial to disclose his financial interest and the applicants for drug registration to submit the statement about the financial conflict of interest of researchers to the drug administration department.

OBJECTIVE:To improve the formula of urea cream and establish its quality control methods.METHODS:The matrix component of formula was adjusted to prepare O/W matrix.Prednisone was added into matrix to prepare urea cream;UV spectrophotometry was applied to determine the content of urea and evaluate the quality of preparation and the stability of 3 batches of samples setting for 40 days under different conditions.RESULTS:The preparation was white cream and its inspection results were in line with the standards stated in Chinese Pharmacopoeia(2005 edition).The linear range of urea was 30.5～180.2 ?g?mL-1(r=0.999 0) with an average recovery of 99.68%(RSD=0.49%).The quality of 3 batches of samples kept stable during observation.CONCLUSION:Improved formula is reasonable,simple in preparation technology and quality control.