Objective To analyze the relationship between diameter and prognosis in atrial septal defect ( ASD) children.Methods The clinical data in 91 cases with ASD were observed.According to ASD diameter,they were divided into three groups,0.5-0.7cm in group A,>0.7-1.0cm in group B,>1.0cm in group C.According to the age of children with size,≤1 years old children with group D,group E,>1 years old children.Statistical ASD diameter and age of the patients and the relationship between natural healing.Results A group of ASD diameter in 0.5-0.7cm 13 cases,the number of natural healing rate in 9 cases(69.23%) .Group B of ASD diameter of 0.8 to 1.0 cm in 33 cases,the number of natural healing rate in 9 cases (27.27%).44 cases in group C ASD>1.0cm in diameter,in which 1 cases (natural healing rate 2.27%).Group A was higher than that in group B and C (χ2 =6.89,27.22,all P<0.05).B group than in C group (χ2 =8.57,P<0.05).Group D patients older than 1 years were 29 cases,in which the natural healing rate in 27 cases (93.10%) ,higher than that of E group of 1 year old chil-dren's natural healing rate was 17 cases (27.42%),two groups had significant difference (χ2 =34.14,P<0.05). Conclusion ASD diameter≤0.7cm and age<1 ASD natural healing probability.ASD>1.0cm in diameter and 1 years of age or ASD natural healing a very small chance.

Pancreatic cancer is one of the cancers with the worst prognosis, and its high metastasis rate and resistance to chemotherapy drugs have always been the tough problems in the medical field. At present, the effect of thymoquinone on pancreatic cancer has attracted wide attention, and it can exert an antitumor effect in pancreatic cancer by inhibiting cancer cell proliferation, promoting cancer cell apoptosis, inhibiting invasion and metastasis, enhancing the sensitivity to chemotherapy drugs, and exerting an anti-inflammatory effect. This review briefly introduces the current research status of the association between thymoquinone and pancreatic cancer in China and globally, so as to provide a reference for subsequent research.