1.Analysis of death cases of dermatomyositis/polymyositis patients: a single-center retrospective study of 28 years
Jingjing CHEN ; Chanyuan WU ; Linrong HE ; Jinmei SU ; Qian WANG ; Fengchun ZHANG ; Xiaofeng ZENG
Chinese Journal of Rheumatology 2015;19(10):669-673
Objective To investigate the changes of major causes of death in patient with dermatomyositis/polymyositis (DM/PM) and the factors affecting the mortality of DM/PM in the past 28 years.Methods Death cases with DM/PM from 1985 to 2013 were retrospectively analyzed.x2 test and Fisher exact test was used for count data analysis;independent samples t-test measurement was used for data analysis;P<0.05 was consi-dered statistically significant.Results Out of 1 443 patients with DM/PM, 74 died, in whom 48 were female and 26 were male.The mortality rate was 4.7% among female and 6.3% among male cases and the total in-hospital mortality of DM/PM was 5.1%.The two most common causes of death in patients with DM/PM were infection and respiratory involvement, accounting for 62.2% (46/74) and 14.9% (11/74) respectively.Death occurred most commonly in the first year after disease onset, accounting for 79.7%(59/74).The leading causes of death in the first year were infection and respiratory involvement.The mortality of DM/PM patients was peaked 12.3%(18/146) from 1996 to 2000;infection was the most frequent cause of death.Conclusion Infection and respiratory involvement are the main causes of death in DM/PM.Death occurrs most commonly in the first year after disease onset.