Objective To observe the clinical effect of penehyclidine hydrochloride(Changtuoning)combined with atropine in treatment of patients with severe acute organophosphorus poisoning(AOPP). Methods The clinical data of 64 patients with severe AOPP admitted into Taizhou Municipal Hospital in Zhejiang Province and Quannan County People's Hospital in Jiangxi Province from January 2004 to September 2012 were retrospectively analyzed. Patients were divided into penehyclidine hydrochloride and atropine combined group(PH-A group,32 cases)and atropine treatment group(32 cases)depending on the difference in selection and application method of anticholinergic drugs. The application of anticholinergic drugs,length of mechanical ventilation,70%cholinesterase (ChE)activity recovery time,length of stay in hospital,incidence of complications,and cure rate were compared between the two groups. Results Compared with atropine treament group,the total usage of atropine in PH-A group was significantly decreased(mg:35.39±45.76 vs. 105.46±139.87,P<0.05),the length of mechanical ventilation (days:5.3±4.2 vs. 7.8±6.8,P<0.05),70%ChE activity recovery time(days:8.2±3.8 vs. 11.0±5.4,P<0.05), and length of stay in hospital(days:12.0±3.8 vs. 14.6±5.3,P<0.05)were significantly shortened in PH-A group, and the overall incidence of complications were significantly lowered in PH-A group〔68.75 %(22/32)vs. 93.75%(30/32),P<0.05〕. The difference in cure rate between the combined group and atropine treatment group was not statistically significant〔96.87%(31/32)vs. 90.62%(29/32),P>0.05〕. Conclusion Penehyclidine hydroehloride combined with atropine in the treatment of severe AOPP can significantly improve the therapeutic efficacy,reduce the incidence of complications and length of stay in hospital.

Objective To compare the clinical effect of penehyclidine hydrochloride and atropine in the treatment of acute organophosphorus pesticide poisoning.Methods 86 patients with organophosphorus pesticide poisoning were selected and randomly assigned to the observation group and the control group according to the digital table,43 cases in each group.The two groups were given conventional treatment,while the control group was treated with atropine,the observation group was given penehyclidine hydrochloride.The disappearance time of main symptoms, rescue success rate and adverse reactions of the two groups were observed.Results After salvage treatment, the rescue success rate of the observation group was 97.8%,which of the control group was 88.4%,the difference was statistically significant (x2=1.433,P<0.05).The disappear time of M like symptoms,N like symptoms and central nervous system symptoms in the observation group was significantly shorter compared with the control group (all P<0.05).The number of drugs,dosage,cholinesterase recovery time and hospitalization time between the two groups had statistically significant differences (P<0.05).The incidence rates of blurred vision,restlessness,heart rate and urinary retention in the control group were significantly higher than those in the observation group (all P<0.05).Conclusion Penehyclidine hydrochloride for acute organophosphorus pesticide poisoning can significantly reduce the incidence of symptoms,shorten the disappearance time of symptoms,reduce hospitalization time,improve the efficacy of rescue,reduce the incidence of adverse reactions, it is safe,effective and has great clinical significance.

AIM: To study the tumor metastasis-related genes expression in adenomyosis and normal endometrium in order to investigate the pathogenesis of adenomyosis. METHODS: 43 specimens of adenomyosis, 22 specimens of controls (normal endometrium) were studied. The expressions of nm23-H1, MMP-2, MMP-9, MT1-MMP, and TIMP-1 in adenomyosis and controls were detected by immunohistochemical method. RESULTS: The expression levels of MMP-2, MMP-9, and MT1-MMP in adenomyosis were significantly higher than those in controls ( P 0 05). CONCLUSION: MMP-2, MMP-9, especially MT1-MMP, maybe play an important role in the pathogenesis of adenomyosis.

Objective: To investigate the activities of daily living and the use of assistive devices among disabled people demanding assistive devices in Jiading Township, Jiading District, Shanghai Municipality, so as to provide the evidence for the implementation of rehabilitation interventions and the selection of assistive devices for the disabled people living in the community. Methods: The disabled people demanding assistive devices were sampled from 17 communities in Jiading Township in January 2020. A face-to-face questionnaire survey was conducted to collect participants'age, gender, type of disability, provision and use of assistive devices. The activities of daily living were evaluated using the Activities of Daily Living Scale, and the difference in the frequency of assistive device use was compared among the disabled people with different activities of daily living. Results: A total of 377 questionnaires were allocated, and 328 valid questionnaires were recovered, with an effective recovery rate of 87.00%. The respondents included 187 men ( 57.01% ) and 141 women (42.99%), and had a mean age of ( 71.78±13.86 ) years. Among all respondents, limb disability was predominant (248 people, 75.61%), and 84.45% (277 people) were provided with assistive devices. Assessment of activities of daily living showed complete self-care in 85 respondents ( 25.91% ), functional decline in 39 respondents ( 11.89% ) and functional dysfunction in 204 respondents ( 62.20% ). The proportion of functional dysfunction was predominantly detected among disabled people at ages of 80 years and older ( 79.63% ) ( P<0.05 ). Of the disabled people with assistive devices, 139 people used the devices daily ( 50.18% ), and the proportion of daily use of assistive devices was significantly higher in people with functional dysfunctions than in those with complete self-care ( 59.33% vs. 29.41%; P<0.05 ). In addition, no need was identified as the predominant cause of non-provision of assistive devices ( 29 people, 56.86% ). Conclusions Functional dysfunction of daily living is highly prevalent among the disabled people demanding assistive devices in Jiading Township, in whom the elderly are predominant, and the proportion of assistive device use is high among people with functional dysfunctions. The provision of assistive devices recommends to be improved based on assessment of activities of daily living.

Traditional Chinese Medicine (TCM) is the treasure of Chinese civilization. It embodies the characteristics and essence of the outstanding culture of China. As the indispensable platform, Chinese medicine museum plays an important role to spread the TCM culture and educate the public. This articl analyzes the difficulties and challenges of propagation and education of TCM in the museum field, explores the effective strategies from four aspects, covering the content construction, interpretation, education activities, and temporary exhibitions. Only in this way, the public education would be promoted effectively in the museum field.