This paper summarizes nursing care of a patient with wound infection following systemic lupus erythematosus (SLE) accompanied by herpes zoster. Aimed at the patient's characteristics of long-term disease course of SLE,weak immune system caused by long-term use of glucocorticoid and immunosuppressant,big wound area with severe infection,and hard healing,moist therapy was implemented under the theoretical guidance of moist healing environment. The Purilon Gel and Biatain-Ag Foam dressing were applied in the wound combined with systemic use of antibiotics and treatment of SLE. At the same time,psychological nursing and health education were provided for the patient. These measures speeded up the wound healing.