Objective To discuss the effects of 6Emodel on stress distress in patients with colorectal cancer after permanent intestinal stoma and to provide reference for the implementation of psychological intervention. Methods A total of 168 patients with permanent intestinal stoma were divided into control group(85 cases)and intervention group(83 cases).In the control group,routine nursing was adopted,while in intervention group,nursing based 6Emodel (including experience,environment,event,engaging,effect,expand)was adopted.The time of intervention was 1 year,and the psychological distress scale for cancer patients was tested.Results After interven-tion,the psychological distress of the intervention group was (39.62 ±14.62)points,which was lower than (46.21 ± 13.68)points of the control group,the difference was statistically significant between the two groups(t =3.057,P =0.002).Conclusion The 6Emodel can reduce the level of psychological distress of colorectal cancer after per-manent intestinal stoma,and has positive effects on the early distress following stoma.The intervention can be one of the effective ways to implement psychological intervention for patients with stoma.

Objective To discuss the effects of simulation -based team training on early adaptation and stress in patients with permanent intestinal stoma.Methods 164 patients with permanent intestinal stoma were divided into control group(82 cases)and intervention group(82 cases).In control group,routine peri -operational health education was adopted,while in intervention group,health education based simulation -based team training was adopted. Then,the intervention effects of ostomy adjustment inventory and stress distress were evaluated.Results After the intervention,there was significant difference between two groups at the level of ostomy adjustment inventory and stress distress(all P <0.05).Conclusion The simulation -based team training could increase the level of ostomy adjust-ment inventory,but reduce the level of stress distress.

Bone morphogenetic protein (BMP) homodimers are of significant osteoinductivity. However, their clinical application is limited because of high effective dosage. Recently, BMP heterodimers are reported to address the issue. This is a review of the researches on BMP heterodimers, including existent evidences, types and synthetic methods, biological activities in comparison to BMP homodimers and possible mechanisms, further research direction and future expectations.
Animals ; Biopolymers ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Protein 7 ; Bone Morphogenetic Proteins ; genetics ; pharmacology ; Humans ; Protein Multimerization

OBJECTIVE: To investigate the clinopathological characteristics, differential diagnosis, therapy and prognosis of sinonasal mucosal malignant melanoma. METHOD: Clinopathological data of 18 cases which were diagnosed by pathology and immmunohistochemistry were analyzed retrospectively. All cases were proved by pathology and immmunohistochemistry. All cases were performed operations. 5 underwent single surgery. 4 underwent surgery plus adjuvant radiotherapy. 4 underwent surgery plus adjuvant radiotherapy chemotherapy. 5 underwent surgery plus adjuvant chemoradiation. RESULT: All cases were followed up for a period of 1 to 7 years after operation. Twelve patients died of tumor until the last follow-up, meanwhile 6 patients stayed alive. In Six cases recurrence occurred. In five casescervical lymph node metastasis occurred, of which 3 cases received neck dissection and 2 cases received chemotherapy and radiotherapy due to no surgical indications. In three cases distant metastasis oc- curred. CONCLUSION Sinonasal mucosal malignant melanoma is rare and highly heterogenous. Current diagnosis depends on clinical characteristics and immunohistochemical examination. It still should be differentially diagnosed from other tumors. CT and MRI image examination can provide some helpful information to understand the extent and nature of lesions. The treatment of nasal endoscopic or the surgery under endoscopy has become to be a safe, viable and reasonable alternative to open resection. Appropriate indication must be carefully selected for these lesions.
Chemotherapy, Adjuvant ; Endoscopy ; Humans ; Lymphatic Metastasis ; Melanoma ; drug therapy ; pathology ; surgery ; Mucous Membrane ; Neck Dissection ; Neoplasm Recurrence, Local ; Nose Neoplasms ; Paranasal Sinus Neoplasms ; drug therapy ; pathology ; surgery ; Prognosis ; Radiotherapy, Adjuvant ; Retrospective Studies

OBJECTIVE: To investigate the clinical features, therapeutic methods and therapeutic efficacy of imflammatory myofibroblastic tumor(IMT)of the nasal cavity and paranasal sinuses. METHOD: Clinical data of 14 cases diagnosed as IMT by pathology were retrospectively analyzed. There were 8 males and 6 females,age ranging from 18 to 77 years. 12 cases of them were treated by surgery while 2 cases received postoperative radiotherapy. RESULT: All cases were operated. All the patients were followed up for a period of 1 to 7 years after operation and two cases were proved low grade IMT pathologically. Eight cases survived with no recurrence until the last follow-up and 6 cases relapsed, of which 4 cases died and 2 were alive with tumor. CONCLUSION IMT of the nasal cavity and paranasal sinuses is very rare. The diagonosis of IMT is based on pathology and immunohistochemistry. Proper diagnosis is essential to avoid mutilating and disfiguring surgical procedures. Radical excision is still the first choice of treatment for IMT of the nasal cavity and paranasal sinuses. Chemotherapy and radiotherapy may not be helpful to prevent recurrence after operation. Due to high recurrence rate, long-term follow up is necessary after operation.
Adolescent ; Adult ; Aged ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Nasal Cavity ; pathology ; Neoplasm Recurrence, Local ; Neoplasms, Muscle Tissue ; pathology ; radiotherapy ; surgery ; Paranasal Sinus Neoplasms ; pathology ; radiotherapy ; surgery ; Paranasal Sinuses ; pathology ; Retrospective Studies ; Young Adult

Objective To test the expression level of IL-37 in peripheral blood mononuclear cells (PBMCs)of patients with primary biliary cirrhosis (PBC)and further explore its clinical significance in the pathological process of PBC.Methods Pe-ripheral blood samples were collected from 42 patients diagnosed as PBC and 38 health individuals examined at the same time during June 2013 to August 2015 in Changhai Hospital.PBMCs were separated by sucrose density gradient centrifugation, qualified Real Time-Polymerase Chain Reaction (qRT-PCR)was used to measure IL-37 mRNA expression level in PBMCs. Enzyme-Linked Immuno Sorbent Assay (ELISA)was to measure the protein level of IL-37,IL-6,IL-17,TNF-α,TGF-β,IL-18 and IL-23 in plasma.Meanwhile,the pathological stages of PBC cases were recorded.Pearson correlation analysis was performed on IL-37 and IL-6,TNF-α,IL-17,TGF-β,IL-18 and IL-23.Spearman rank correlation analysis was on IL-37 and pathological stages of PBC.Results The mRNA and protein level of IL-37 in experimental and controlled group were 2.81 ±0.94 vs 1.09±0.56,356.14±169.36 pg/ml vs 86.68±48.23 pg/ml separately(t=9.811,9.462,P<0.000 1),with sta-tistical differences.The correlation analysis showed that IL-37 was positively related with IL-17,TNF-α,IL-6 and TGF-β(r=0.561 2,0.661 9,0.672 1,0.765 3,P<0.001),and disease stages (Ⅰ~Ⅳ)(rs=0.348 9,P<0.05).Conclusion IL-37 might involve in the pathological process of PBC,and it is significant for disease prediction and diagnosis.

Objective To investigate the effect of evidence-based nursing on postoperative urinary retention in patients undergoing laparoscopic hysterectomy.Methods A total of 45 patients with laparoscopic hysterectomy in our department were as the observation group,given evidence-based nursing to prevent urinary retention.A total of 40 patients with laparoscopic hysterectomy were given routine nursing as the control group.The postoperative urination,urinary retention and urinary catheter removal were compared.Results Autonomous urination recovery time in the observation group was shorter,the first micturition volume was more,the residual urine volume was less,urinary tract infection and urinary retention rate were lower than that in the control group,the differences were statistically significant (P ＜ 0.05).The pain in the observation group was slightly lighter than that in the control group,and the difference was statistically significant (P ＜ 0.05).Conclusion Evidence-based nursing can improve the urination,reduce the incidence of urinary retention and reduce the pain of patients after laparoscopic hysterectomy.

Objective To investigate the effect of evidence-based nursing on postoperative urinary retention in patients undergoing laparoscopic hysterectomy.Methods A total of 45 patients with laparoscopic hysterectomy in our department were as the observation group,given evidence-based nursing to prevent urinary retention.A total of 40 patients with laparoscopic hysterectomy were given routine nursing as the control group.The postoperative urination,urinary retention and urinary catheter removal were compared.Results Autonomous urination recovery time in the observation group was shorter,the first micturition volume was more,the residual urine volume was less,urinary tract infection and urinary retention rate were lower than that in the control group,the differences were statistically significant (P ＜ 0.05).The pain in the observation group was slightly lighter than that in the control group,and the difference was statistically significant (P ＜ 0.05).Conclusion Evidence-based nursing can improve the urination,reduce the incidence of urinary retention and reduce the pain of patients after laparoscopic hysterectomy.

Objective To investigate the clinical features,therapeutic methods and therapeutic effects of sinonasal hemangiopericytoma.Methods Clinical data of 6 patients with sinonasal hemangiopericytoma,diagnosed by pathology and immmunohistochemistry between January 1990 and December 2012 were analyzed retrospectively.There were 4 males and 2 females,with a median age of 58 years.Clinical manifestation included epistaxis and nasal obstruction.These patients were operated on by nasal endoscopic surgery or endoscope-assisted surgery,of which 2 cases of tumor located in the nasal cavity underwent nasal endoscopic surgery and 4 cases of tumor located in the nasal cavity and sinuses underwent endoscope-assisted surgery.Results All the patients were followed up for a period of 6 months to 7 years after operation.Two cases recurred and 4 cases didn't recurre.One case recurred 6 months after operation and underwent second operation,with no recurrence by further one year follow-up.Another case recurred 17 months after operation and underwent second operation,with recurrence by further 9 months follow-up.This patient lived with tumor over two years.Conclusions Hemangiopericytomas are rarely found in the sinonasal cavity.Nasal endoscopic or endoscope-assisted surgery provides satisfactory effect.

Mechanical ventilation(MV)provides life support for critically ill respiratory patients,but in the meantime can cause fatal ventilator-induced lung injury(VILI),and the latter remains a major challenge in respiratory and critical care medicine,because the pathological mechanism has not been fully elucidated.Recent studies show that on the one hand,in the lung with VILI,there exists airway collapse at multi-sites of an individual airway,which can not be explained by traditional airway collapse models.But on the other hand,under MV conditions,airway smooth muscle cells(ASMC)exhibit abnormal mechanical behaviors,accompanied by regulation of Piezo1 expression and endoplasmic reticulum stress.These phenomenons indicate that the MV-induced abnormal mechanical behavior of ASMC is closely related to multiple airway collapse and VILI.Therefore,by studying the MV-induced changes of ASMC mechanical behaviors and their relationship with airway collapse in lung injury,as well as the related mechanochemical signal coupling process,it is expected to reveal a novel mechanism of MV-associated airway collapse and lung injury from the perspective of cell mechanics.In this review,the recent research progress of airway collapse during MV,the regulation of ASMC mechanical behavior by MV-related high stretch,especially the related mechanochemical signal coupling mechanism is summarized.These advances may provide a novel insight for exploring the roles of ASMC abnormal mechanical behavior in the pathological mechanism of VILI,alternative targets of drug intervention for prevention and treatment of VILI,as well as for optimizing the ventilation mode in clinical practice.