Objective To study the effect of tetracaine jelly on hemodynamics during extubation period in general anesthesia.Methods One hundred patients who performed tracheal cannula and general anesthesia were divided into control group (50 patients) and experiment group (50 patients) by random digits table method.Control group:sterile paraffin oil was applied to the endotracheal tube.Experiment group:tetracaine jelly was applied to the endotracheal tube.The systolic blood pressure (SBP),diastolic blood pressure (DBP) and heart rate(HR) were measured before the anesthesia induction(T1),5 min after stopping infusion drugs (T2),1 min after tracheal extubation (T3),3 min after tracheal extubation (T4) and 5 min after tracheal extubation (T5) were observed.The resistant effect after waking and the number of sore throat,hoarseness were recorded.Results The level of SBP,DBP,HR at T1 and T2 had no significant difference between two groups (P ＞ 0.05).The level of SBP,DBP,HR at T3-T5 in experiment group were significantly lower than those in control group [SBP:(122.3 ± 11.3),(120.0 ± 9.8),(112.0 ± 6.3) mmHg (1 mmHg =0.133 kPa) vs.(158.3 ± 15.0),(142.5 ± 13.5),(133.0± 14.5) mmHg;DBP:(75.0 ± 13.5),(75.8 ± 10.5),(58.3 ±4.2) mmHg vs.(111.0 ± 20.3),(106.5 ± 12.8),(63.8 ± 15.8) mmHg;HR:(81.9 ± 13.7),(83.6 ± 13.4),(60.7 ± 3.5) times/min vs.(113.5 ± 19.4),(117.5 ± 21.7),(71.8 ± 14.6) times/min](P ＜ 0.05).The total effective rate of tolerance in experiment group was higher than that in control group [96％(48/50) vs.56％(28/50)],the rate of sore throat and hoarseness were lower than those in control group [6％ (3/50) vs.48％ (24/50),4％ (2/50) vs.36％ (18/50)],there were significant differences (P ＜ 0.05).Conclusion Tetracaine jelly can reduce the cardiovascular response of tracheal extubation,enhance the tolerance of tracheal tube and decrease the morbidity of sore throat and hoarseness.

Objective To investigate the relationship between arterial elasticity and left ventricular twist in patients with essential hypertension (EH).Methods Sixty patients with EH who were treated in the First Affiliated Hospital of the Medical College of Shihezi University from October 2014 to June 2015 as the EH group,and 60 healthy persons in the same period as the control group.The systolic blood pressure (SBP),diastolic blood pressure (DBP),pulse pressure (PP) were measured.Ascending aortic systolic diameter,diastolic diameter were detected by ultrasonic technology.Aortic strain (AS),aortic stiffness (β) and aortic distensibility (AD) were calculated.Left ventricular basal peak rotation(PBR) and apical peak rotation(PAR) were detected by speckle tracking imaging(STI),and the left ventricular peak twist(Ptw) was calculateby.Results The β,PP and Ptw in EH group were 3.99±0.47,(74.2±10.4) mmHg and (21.73±2.30) °respectively,in the control group were 2.75 ± 0.27,(45.9 ± 5.1) mmHg and (14.04 ± 2.90) ° respectively,and the differences were significant(P=0.000).AS and AD in Eh group were 0.034±0.012,1.00±0.47 respectively,in the control group were 0.106 ± 0.028,4.69 ± 1.37 respectively,and the differences were significant (P =0.000).Pearson correlation analysis showed there were opsitive correlation between β with PBR,PAR and Ptw (correlation coefficient =0.361,0.719,0.730;P＜0.01 or P＜0.05),and negative correlation between AD with PBR,PAR and Ptw(correlation coefficient =-0.279,-0.625,-0.610;P＜0.01 or P＜0.05).Conclusion β,PP and Ptw are high,while AS,AD are poor in patient with EH,and there are associations between β,AD with PBR,PAR and Ptw.

Objective To investigate the effects of Matrine on proliferation and apoptosis of human cervical carcinoma cell line Hela in vitro. Methods Human cervical carcinoma cell line Hela was cultured in vitro. Cell proliferation was assessed by MTT colorimetric assay. The percent age of apoptosis cells was detected by TUNEL staining. The expression of PCNA protein was displayed with immunohistochemistry. Results Proliferation of Hela cells was inhibited in 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0g/L Matrine-treated groups compared with those in the control group(P