目的评价护理干预在社区老年慢性病患者健康管理中的效果。方法对本管辖社区内171例60岁以上社区老年慢性病患者实施护理干预，包括健康教育、端正治疗的态度和信念、合理搭配膳食、调节情绪、适量运动、每周对病情的跟踪随访等。结果2年后社区老年慢性病患者在参加体育锻炼、低盐摄入、身体不适就医、保持心情舒畅、遵医服药方面有显著性差异（P<0.05）。结论社区护理干预改变了社区老年慢性病患者不良的生活方式，增强了患者的自我管理能力。

OBJECTIVE:To study the bioequiavailability of sodium/calcium folinate for injections in healthy volunteers.METHODS:By a randomized crossover design,trichloracetic acid was used to precipitate the protein in serum sample.Serum concentration of folinate was determined by RP-HPLC.The pharmacokinetic parameters and relative bioavailability of sodium folinate for injection vs.calcium folinate for injection were computed and analyzed statistically.RESULTS:The pharmacokinetic parameters of single dose of sodium folinate for injection(trial formulation)vs.calcium folinate for injection(reference formulation)were as follows:tmax(0.292?0.096)h vs.(0.25?0)h;Cmax(31.973?4.337)?g?mL-1 vs.(33.332?3.312)?g?mL-1;AUC0～24(139.670?13.859)?g?h?mL-1 vs.(144.401?13.574)?g?h?mL-1;AUC0～∞(154.246?16.481)?g?h?mL-1 vs.(161.306?17.871)?g?h?mL-1;MRT0～24(6.795?0.73)h vs.(6.963?0.713)h;t1/2(7.183?1.469)vs.(7.316?2.045).The mean relative bioavailability of the sodium folinate for injection was(98.2?37.1)%.CONCLUSION:The two formulations are proved to be bioequivalent.

Objective:To explore the correlation between medication adherence and quality of life (QOL) in aged pa‐tients with hypertension from communities .Methods :Chinese questionnaire of quality of life in patients with cardi‐ovascular disease (CQQC) and Morisky medication adherence scale were used to investigate and analyze 197 aged pa‐tients with hypertension from communities .Results:Total score of CQQC was (78.69 ± 9.36) scores in the 197 aged patients with hypertension from communities .In which ,77 cases (39.09% ) possessed good medication adherence , and 120 cases ( (60. 91% )) with poor adherence to medication . Compared with those with poor adherence to medi‐cation,therewassignificantriseintotalscoreofCQQC [(75.73±8.52)scoresvs.(83.31±8.76)scores ,P<0.01] .Pearson correlation analysis indicated that QOL was significant positively correlated with medication adher‐ence (r=0.397 , P<0.01) .Conclusion:Community health staff should pay attention to influencing factors of med‐ication adherence in aged patients with hypertension ,take individualized and targeted interventional measures to im‐prove their adherence to medicationand quality of life .

Objective To evaluate the diagnostic value of endobronchial ultrasound-transvascular needle aspiration(EBUS-TVNA)in hilum of lung and mediastinal lesions.Methods 10 cases of hilum of lung and mediastinal lesions who underwent EBUS-TVNA because vessels pass between the airway and lesions were selected from June 2021 to January 2023,the diagnostic rate and complications were retrospectively analyzed.Results Of the 10 patients,8 traversed the pulmonary artery or its branches,2 traversed aorta or superior vena cava.Specimens were successfully obtained from all patients and 8 of them got definitive diagnosis,including 6 malignancy and 2 benign lesions.The overall yield of EBUS-TVNA for hilum of lung and mediastinal lesions was 80.0%(8/10),the diagnostic sensitivity for malignancy was 85.7%(6/7),and the diagnostic specificity was 100.0%(3/3).The other 2 cases were not diagnosed,1 was diagnosed as bladder urothelial carcinoma by percutaneous lung puncture biopsy,and the other was classified as benign due to the reduced lesion after 6 months of follow-up.All of them had good tolerance to the operation,and no serious complications occurred.Conclusion EBUS-TVNA is a safe and effective technique for the diagnosis of hilum of lung and mediastinal lesions,it can be used as an effective auxiliary method to traditional ultrasound bronchoscopy techniques.

Objective To observe whether strength training of a healthy limb can produce a cross transport effect on the affected side.Methods Thirty hemiplegic stroke survivors were randomly divided into an experimental group and a control group,each of 15,using a random number table.Both groups received conventional rehabilitation,while the experimental group was given training to strengthen dorsiflexion and the isometric resistance of their healthy ankles for 6 weeks.The maximum voluntary contraction (MVC) and surface electromyography were measured before and after the training.The lower-extremity section of the simplified Fugl-Meyer motor function rating scale (FMA) was used to assess the subjects' motor function.Results After the training,the average FMA score of the experimental group was significantly better than before the treatment and also significantly better than that of the control group after the treatment.After the training,the average IEMGs of the tibialis anterior muscle and the gastrocnemius in the treatment group were significantly different from those of their ipsilateral side before the treatment and in the control group after treatment.Significant differences before and after the treatment were observed in the average MVC of both tibialis anterior and gastrocnemius muscles in the experimental group,and between the experimental group and control group averages.Conclusion Ankle strength training of hemiplegics' healthy limbs can strengthen the contralateral and antagonistic muscles,which indicates the cross transport of strength training.Isometric resistance training of the less-affected limb can improve the motor function of hemiplegics' lower extremities.

In recent years, the incidence of sleep disorders is increasing gradually, and sleep disorder has become a common and frequently-occurring disease in community. While drugs bring a series of side effects, non-pharmacological therapy has become a hotspot in sleep quality study field. It is found that"Gua sha" therapy has a significant effect in improving sleep quality as one of the traditional Chinese medicine (TCM) care techniques by literature review. This paper summarized the current situation and analyzed the deficiencies of "Gua sha" in sleep improvement basing on the theoretical foundation of Chinese medicine and biological mechanism, so as to provide references for future research and provide guidance for promoting the application of "Gua sha" therapy in community.

AIM:This study aimed to observe the analgesic effects of Hegu acupoint catgut embedding in a rat model of labor and investigate its influence on biomarkers such as calcitonin gene-related peptide(CGRP)signals at the Hegu acupoint.METHODS:Thirty-six pregnant rats were randomly divided into three groups:control group,Hegu acu-puncture group,and Hegu catgut embedding group.Pain threshold changes were assessed using the tail immersion test and paw withdrawal thermal latency at four time points:pre-induction,before the onset of labor,at the onset of labor,and at the mid-stage of labor.Tissue samples from the Hegu acupoint were collected at the mid-stage of labor to detect the ex-pression of CGRP,substance P(SP),and mast cells using immunofluorescence.The concentrations of ATP and ade-nosine were measured using ELISA.RESULTS:Before labor induction,there was no significant difference in tail immer-sion test and paw withdrawal thermal latency among the three groups(P>0.05).Before the onset of labor,both the acu-puncture and catgut embedding groups exhibited significantly higher tail-flick times and paw withdrawal latencies com-pared to the control group(P<0.05).At labor initiation and mid-labor,the catgut embedding group had significantly higher tail-flick times and paw withdrawal latencies compared to both the control and acupuncture groups(P<0.05).During mid-labor,the expression of CGRP,SP,mast cells,ATP,and adenosine concentrations in the catgut embedding group was significantly higher than that in the control and acupuncture groups(P<0.05),with co-expression of CGRP,SP,and mast cells observed.CONCLUSION:Hegu acupoint catgut embedding effectively alleviates labor pain,and its mechanism may involve increased local expression of CGRP and SP,promoting mast cell degranulation,and increasing ATP release and its conversion to adenosine.