1.Effect of ganglioside on nerve function in hypertensive cerebral hemorrhage after operation
Chinese Journal of Biochemical Pharmaceutics 2016;36(9):132-134
Objective To investigate the effect of ganglioside on nerve function in patients with hypertensive cerebral hemorrhage after operation. Methods 90 cases with hypertensive cerebral hemorrhage after operation from March 2014 to March 2016 in our hospital were divided into control group and observation group, the control group was treated with routine treatment, the observation group was given ganglioside nerve cell nutrition therapy, the two groups of patients after treatment of clinical efficacy, neurological function score, ADL score, hematoma, edema were observed.Result The total effective rate(91.11%) in the observation group was significantly higher than that in the control group(66.67%)(P <0.05), the difference was statistically significant.After 7 days and 28 days after treatment, the volume of hematoma and edema in the observation group was significantly decreased, and the control group had obvious advantages compared with the control group ( P <0.05 ).Compared with seventh days and twenty-eighth days after treatment, the NIHSS score and ADL score of the observation group were significantly better than the control group ( P <0.05 ) , the difference was statistically significant.Conclusion The application of the ganglioside in the treatment of hypertensive cerebral hemorrhage can significantly improve the neurological function, improve the quality of life of patients and clinical treatment effect, has good clinical application value.
2.Effect of standardized lymph node sorting on surgical treatment of gastroesophageal junction malignant tumors
Huihu He ; Kaiji Gao ; Jiahe Sun ; Qiyang Yao ; Shijie Zhang ; Lingjun Geng
Acta Universitatis Medicinalis Anhui 2024;59(8):1465-1470
Objective :
To investigate the effect of standardized lymph node sorting on postoperative results of gas- troesophageal junction malignant tumors.
Methods :
The data of all patients with malignant gastroesophageal junc- tion in gastric cancer database were analyzed retrospectively.Lymph nodes were sorted according to whether sur- geons were present immediately after surgery.Patients were divided into lymph node sorting group (sorting group) and lymph node unsorting group (unsorting group) .General data included gender,age,body mass index (BMI) , carcinogenic antigen ( CEA) ,postoperative albumin level,preoperative hemoglobin,etc.Perioperative and patho- logical data included operation time,intraoperative blood loss,postoperative hospital stay,tumor differentiation, distance from superior incisal margin,total number of lymph nodes,number of positive lymph nodes,etc.Kaplan- Meier curve and Log-rank test were used for survival analysis,and propensity score matching analysis adjusted for confounding factors between groups.
Results :
A total of 386 patients were included,including 133 in lymph node sorting group and 253 in non-sorting group.The median follow-up time was 40. 18 months.The total number of lymph nodes and the number of positive lymph nodes in the sorting group were (26. 38 ± 12. 18) and (6. 63 ± 10. 14) ,respectively,while the total number and the number of positive lymph nodes in the non-sorting group were ( 12. 25 ± 7. 06) and (3. 07 ± 3. 77) ,respectively.There were statistically significant differences in the total num- ber of lymph nodes and the number of positive lymph nodes between the sorting group and the non-sorting group (P <0. 05) .There was no statistically significant difference in survival between the sorting group and the non-sorting group before matching.There were 112 and 203 patients with advanced gastric cancer in the two groups,respec- tively.The overall survival curve of patients in the sorting group was better than that in the non-sorting group,and the difference in median survival time was statistically significant (P<0. 05) .The caliper value was set to 0. 02, and 94 pairs of patients were preferentially matched.After matching,the total number of lymph nodes and the num- ber of positive lymph nodes in the sorting group were (24. 71 ± 12. 03) and (5. 70 ± 9. 95) ,respectively,while the total number and the number of positive lymph nodes in the non-sorting group were ( 13. 05 ± 7. 63) and (3. 37 ± 4. 32) ,respectively.The difference between the two groups was statistically significant (P<0. 05) .The overall survival curve of patients in the sorting group was better than that in the non-sorting group,and the median survival time was statistically significant (P<0. 05) .
Conclusion
Postoperative lymph node sorting for gastric cancer can significantly increase the number of total lymph nodes and positive lymph nodes,reduce lymph node migration,and improve postoperative survival time.