Objective To study the related risk factors and comparison between adenomyosis and uterine myoma in order to find the same and different ways of preventing adenomyosis and uterine myoma.Methods Clinical data of 200 cases of adenomyosis and 200 cases of uterine myoma were retrospectively analyzed.Results There was no significant difference in the incidence of different ages between adenomyosis and uterine myoma (P ＞ 0.05).There were significant differences in A blood type,family history,dysmenorrhea and using intrauterine device between adenomyosis and uterine myoma (85 cases vs.56 cases,9 cases vs.36 cases,163 cases vs.71 cases,104 cases vs.79 cases,P ＜ 0.05),but there was no significant difference in occupation,education,previous gynaecopathia inflammatory disease,age of menarche,menstrual cycle,menstruation,infertility,the first gestational age,parity,abortion numbers between adenomyosis and uterine myoma (P ＞ 0.05).Conclusions The adenomyosis and uterine myoma may be associated with the stimulation by high level of female hormone.Compared with uterine myoma,adenomyosis seems to be related to A blood type,dysmenorrhea and using intrauterine device.

Objective To explore the relationship between primary hepatic cancer (PHC) and hepatitis B virus(HBV),hepatitis C virus(HCV),and discuss the relationship between PHC and HBV,HCV overlapping infection.Methods To examine hepatitis B virus markers (HBV-M) and anti-HCV in 206 cases PHC.Results In 206 cases,patients with HBV infection correlation is 93.20％.Most of cases (43.20％) showed the HBsAg,anti-HBe and anti-HBc positive,followed by HBsAg and anti-HBc positive (19.90％),and few of cases showed the other expression patterns in PHC HBV-M pattern.In 206 cases,patients with HCV infection correlation is 18.45％,overlapping infection patients are 24 cases (11.65％).Conclusion PHC are closely associated with HBV,HCV infection that are the important factors in the development of PHC occurrence.We should regular examine the patients who infect HBV and HCV,between 40 and 60 years old,especially with cirrhosis,we stive to make the PHC early detection,early treatment,in order to improve the survival rate of PHC.

Objective To examine the moderating effects of cognitive emotion regulation strategies on neuroticism and depression in college students.Methods Correlation and Hierarchical Regression Analysis were used to analyze the surveyed data collected from 824 college students.Results Among all the cognitive emotion regulation strategies,college students used the rational analysis most frequently (14.1 ± 2.57) and used the catastrophizing least frequently(7.74±2.76).After controlling the effects of depressive symptoms at T1,the standard regression coefficients of neuroticism to depression were significant (β=0.137,P＜0.001).The standard regression coefficients of positive refocusing to depression (β=-0.073,P＜0.05) and the standard regression coefficients of rumination and catastrophizing to depression were all significant(β=0.137,P＜0.001 ; β=0.143,P＜0.01).The interaction between neuroticism and catastrophizing were significant (β=0.0535,P＜0.05),whereas the interaction between neuroticism and blaming others were significant(β=-0.620,P＜0.01).Conclusion Catastrophizing positively moderates the effects of neuroticism on depression,while blaming others negatively moderates the effects of neuroticism on depression.

This article reviewed the digestive system characteristics,enteral nutrition style,milk choice,the starting time of enteral nutrition,the velocity of milk volume increased and the ideal growth velocity of very low birth weight infants.The aim was to investigate the effect of the different starting time of enteral nutrition on their digestive function and the growth velocity,in order to find the suitable starting time of enteral nutrition,providing the basis for clinical enteral nutrition program of very low birth weight infant.

Objective To explore the changes of gastric myoelectrical activity of chronic superficial gastritis after zhizhu capsule treatment.Methods Sixty chronic superficial gastritis patients with dyspepsia were divided into two groups; the control group (n =26) was treated with pantoprazole and mosapride and the treatment group (n =34)with the same drugs combined with ZhizhuKuanzhong capsules for 2 weeks.Gastric myoelectrical activities of all patients were recorded by electrogastrography before and after treatment.The symptoms were scored in 60 chronic superficial gastritis patients according to themodified glasgow method.Results The glasgow scores before and after treatment were(6.12 ± 0.82) and (0.72 ± 0.56),respectively; they were (6.87 ±0.58) and(2.80 ± 1.10) in the control group,respectively.The glasgow scores of the treatment group were decreased more obviously than the control group (t =9.58,P ＜ 0.05).The number of cases in the treatment and control groups which the main power ratio was more than 1 before and after meals was 7 (20.59％),29 (85.29％) and 5 (19.23％),19 (73.08％),respectively.In two groups,there was significantly statistical difference in the percentage of which main power ratio was more than 1 between before and after treatment (x2 =28.57,15.17,P ＜ 0.05).After treatment,there was statistically significant difference in the percentage of normal slow wave and bradygastria before and after meal in two groups[treatment group:before meal:(63.22 ± 10.05)％,(20.35 ± 11.23)％ ;after meal:(68.52 ±13.03) ％,(18.62 ± 10.03) ％ ; control group:before meal:(50.1 ± 16.22) ％,(28.38 ± 17.25) ％ ; after meal:(54.57 ± 18.32) ％,(27.67 ± 16.27) ％] (t =2.18 ～ 3.84,P ＜ 0.05).There was no statistical differences in the percentage of tachygastria before and after meal in two groups (P ＞ 0.05).Conclusions The dyspepsia symptoms of chronic superficial gastritis might be related to the disorder of elactrogastrographic frequency.ZhizhuKuanzhong capsules can effectively improve the gastric myoelectrical activity and relieve the dyspeptic symptom of chronic superficial gastritis patients.

Inherited epidermolysis bullosa (EB) is a group of hereditary skin diseases characterized by increases in skin brittleness and being prone to skin blisters or erosions when the skin is exposed to slight friction or injury. At present, it is classified into four types, namely EB simplex, junctional EB, dystrophic EB and Kindler syndrome. An onion skinning approach is recommended for the diagnosis of inherited epedermolysis bullosa, in which, immunofluorescence mapping is performed firstly, and causative genetic loci are then determined through detection of relevant genes. In its treatment, skin care should be intensified, and medical or surgical treatment may be used to alleviate symptoms. Further development of cell?, protein?and gene?based therapies is expected to bring hope to patients via realization of timely prenatal diagnosis and avoidance of adverse consequences.

As one of active immune effector molecules,immunoglobulins play an important role in the pathogenesis,diagnosis and treatment of autoimmune bullous diseases.Human immunoglobulins can be divided into 5 categories,including IgG,IgA,IgM,IgD and IgE,and all of them participate in and play different roles in the pathogenesis of autoimmune bullous diseases except IgD.IgG can induce the formation of blisters by activating complements and leukocytes as well as by releasing proteolytic enzymes,and different subtypes of IgG differ in biological activities.IgA can cause granulocyte migration and lead to the formation of blisters and pustules.IgE is associated with urticaria-like erythema and eosinophil infiltration.IgM is usually seen in Brazilian pemphigus foliaceus.These findings may provide new ideas for the diagnosis and treatment of autoimmune bullous diseases.

Sepsis refers to the infection caused by systemic inflammatory response syndrome.Sepsis is one of the leading causes of death in critically ill patients in the ICU and its morbidity and mortality are increasing year by year globally.According to statistics,in China,the incidence of sepsis in ICU is 8.68％ and the mortality rate can be as high as 44.7％,therefore,severe sepsis in the field of medicine to become one of the problems to be overcome.MicroRNAs (miRNAs) play an important role in the pathogenesis of sepsis through the TLRs / NF-κB signaling pathways,which play an important role in immune regulation.In this review,the progress of miRNAs involved in TLRs signaling pathway in sepsis is reviewed.

OBJECTIVE:To determine the content of the total flavonoid in Fructus Rosae Laevigatae.METHODS:Dual wavelength TLC scanner was selected with rutin as standard substance.The developing solvent was acetic ether-formic acid-water(8∶1∶1);?s=266 nm,and ?R=230 nm.RESULTS:The linear range of Fructus Rosae Laevigatae was 1～6 ?g,and the average recovery was 98.9% 2.397%(RSD=1.39%,n=6).CONCLUSION:The method is simple and accurate,and it is applicable for the quality control of Fructus Rosae Laevigatae.

A large number of animal experiments have confirmed that ischemic preconditioning can produce a powerful organ protective effect,but the progress and results of the conversion of animal experiments to clinical trials are unsatisfactory.It has great significance for studying of molecular mechanisms of ischemic preconditioning mediated neuroprotection,searching for safe and effective preconditioning induced ways which can be converted to clinical practice,improving the tolerance of nerve tissue ischemia and hypoxia in stroke and surgical patients and achieving a safe and effective neuroprotection.This article reviews the molecular mechanisms of ischemic preconditioning mediated neuroprotection from the aspects of pretreatment of activated receptor,mitochondria,transcription factor,and protein kinase.