Objective To understand the clinical distribution and drug resistance situation of112 strains of Acinetobacter Bau-mannii isolated from the patients′sputum samples in cerebral surgery ICU in order to provide the basis for the rational use of anti-bacterial drugs in clinical therapy.Methods 112 strains of Acinetobacter Baumannii were performed the retrospective analysis.The VITEK2-Compact automatic microbiological analyzer was adopted to conduct the bacterial identification and the drug susceptibility test and the K-B method was combined as the supplement control.The Whonet 5.6 software was used for conducting the statistical analysis.Results Among 112 strains of Acinetobacter baumannii,75 strains(67.0%)were multi-drug resistant,8 strains(7.1%) were pan-resistant.The antimicrobial susceptibility tests showed that the resistant rates of Acinetobacter baumannii to mezlocillin, piperacillin and nitrofurantoin reached up to 100%.Acinetobacter Baumannii had the lower resistant rate to polymyxin B (2.7%), the resistant rates to minomycin and ceperazone/sulbactam were 4.5% and 10.7% respectively.Conclusion The drug resistance phenomena of Acinetobacter Baumannii in the cerebral surgery department ICU is serious.Minomycin,polymyxin B and ceperazone/sulbactam have the better antibacterial activities to clinically isolated Acinetobacter Baumannii and may be the alternative drugs for therapy.Clinic should strengthen the monitoring and rationally use the antibacterial drugs.

Objective To investigate the impacts of Xuebijing injection on systemic inflammatory response and immune function of patients with acute exacerbation of severe chronic obstructive pulmonary disease (AECOPD). Methods A prospective randomized controlled trial (RCT) was conducted. Forty patients with severe AECOPD were divided into control group and Xuebijing group in accordance with the random number table, each group 20 cases. Both groups were treated by routine conventional basic therapy of severe AECOPD including anti-infection, phlegm-expelling formula, bronchodilators and mechanical ventilation, etc, while in Xuebijing group, intravenous drip of Xuebijing (100 mg, twice a day for 5 days) was additionally used. The changes of data of arterial blood gas analysis, blood routine examination, C-reactive protein (CRP), procalcitonin (PCT), immune function, and acute physiology and chronic health evaluation system Ⅱ (APACHE Ⅱ) score before and after therapy were observed and compared between the two groups. The length of stay in hospital, duration of mechanical ventilation, and prognosis were also compared between the two groups. Besides, according to the difference in APACHE Ⅱ score, all the patients were divided into APACHEⅡscore≥15 score group (18 cases) and APACHEⅡscore<15 score group (22 cases), and the immune function were compared between the two groups. Results ①The immune function was descended and disordered in patients with severe AECOPD. Compared with the < 15 score group, the expressions of CD45+, CD3+, CD4+, CD4+/CD8+ ratio, B-lymphocyte, natural killer cell (NK cell) in ≥ 15 score group were significantly lowered [CD45+(×106/L):663.92±100.61 vs. 1 289.92±169.38, CD3+(×106/L):342.05±108.93 vs. 882.37±172.56, CD4+(×106/L):205.96±63.97 vs. 486.24±108.64, CD4+/CD8+ratio:0.76±0.49 vs. 1.32±0.57, B-lymphocyte (×106/L):124.77±32.72 vs. 166.06±48.02, NK cells (×106/L): 186.47±39.57 vs. 243.51±44.72, all P < 0.05]. There was no statistically significant difference in the expression of CD8+ between the ≥ 15 score group and < 15 score group (P > 0.05). ② Compared with those before therapy, the pH value, oxygenation index, arterial partial pressure of carbon dioxide (PaCO2), white blood cell count (WBC), CRP, PCT were significantly improved after therapy in both control and Xuebijing groups. Compared with those in the control group, WBC, CRP, PCT were significantly lowered in Xuebijing group [WBC (×109/L): 10.29±3.83 vs. 12.69±3.42, CRP (mg/L): 9.06±4.19 vs. 15.26±4.22, PCT (ng/L): 0.18±0.21 vs. 0.42±0.24, all P < 0.05]. There were no statistically significant differences in pH value, oxygenation index and PaCO2 between two groups (all P>0.05). The degrees of improvement of CD45+, CD3+, CD4+, CD8+ and CD4+/CD8+ ratio were more remarkable in Xuebijing group after treatment than those in control group [CD45+ (×106/L): 1 079.38±153.86 vs. 1 015.63±157.11, CD3+ (×106/L): 652.05±100.05 vs. 596.81±106.85, CD4+ (×106/L): 358.92±67.53 vs. 329.99±72.61, CD8+ (×106/L): 205.73±35.19 vs. 230.41±39.74, CD4+/CD8+ratio: 2.16±0.63 vs. 1.52±0.54, all P < 0.05]. The B-lymphocyte and NK cell before treatment and after treatment showed no statistical significant differences between the two groups (all P > 0.05). Compared with the control group, the duration of mechanical ventilation (hours: 56.25±22.87 vs. 69.45±26.59) and the length of stay in hospital (days: 11.00±0.74 vs. 14.00±2.06) were shortened, and APACHE Ⅱ score was significantly lowered in Xuebijing group (8.21±2.97 vs. 12.08±3.12, P < 0.05). The numbers of multiple organ failure and dead patients in Xuebijing group were less than those of control group, but no statistical significant differences were found (both P > 0.05). Conclusion Xuebijing injection for treatment of patients with severe AECOPD can ameliorate inflammatory response, improve immune function, shorten the duration of mechanical ventilation and the length of stay in hospital, and decrease the risk of death.

To explore the of occupational therapy for the cerebral palsied children was introduced. The assessment areas of occupational therapy and evaluational instruments commonly used. The last part gives the concrete treatment methods that occupational therapy usually adopts in practice, specially in the fields of training and developing the grass motor skills of the upper limbs, the fine motor skills of the hands and ADL skills of the children with cerebral palsy were also stated.

Objective To investigate the effect of community nursing intervention on the dementia caregivers'quality of life at home.Methods General situation questionnaire,simple intelligent state scale and patients daily life ability scale were used to evaluate patients' medical condition.Health questionnaire (SF-36) was used to assess the caregiver's quality of life at baseline and 3,6,9,12,18 and 24 months after the intervention.Results Compared with the control group,three dimension scores of the caregivers,including physical function(PF),restriction of physical heahh(RP) and mental health(MH),were significantly increased at 9,12,18 and 24 months after intervention,and the difference was significant(PF:t values were 2.084,2.118,2.051 and 2.591,respectively; RP:t values were 2.204,2.377,3.032 and 3.785,respectively; MH:t values were 2.112,2.369,3.204 and 2.913,respectively; all P＜0.05).Moreover,there was significantly difference between the two groups in two dimension scores of restricted role caused by emotional problems(RE) and general health(GH) at 12,18 and 24 months after intervention(RE:t values were 2.211,2.471 and 2.779,respectively; GH:t values were 2.158,2.485 and 2.887,respectively; all P＜ 0.05).For the intervention group,RP,RE,PF,MH and GH at 24 months showed statistically significant difference with baseline(t values were 3.131,3.293,2.457,3.618 and 3.433,respectively; all P＜0.05).However,there was no difference between the two groups in body pain(BP),vitality(VT) and social function (SF),and there was no statistically significant difference before and after the intervention(all P＞0.05).There was no statistically significant difference before and after the intervention in each dimension scores of SF-36 of the control group(P＞0.05).Conclusion Community nursing intervention can improve senile dementia caregivers'quality of life.

Objective To evaluate the effects ofYinhuangdecoction and external application ofXilei decoction in treating vesicular stomatitis.Methods From January 2012 to October 2013, 126 enrolled cases were randomly divided into a treatment group and a control group with 63 in each. The treatment group, which was treated with acycloguanosine tablets as the control group did, was additionally given orallyYinhuang decoction and external application ofXilei decoction. The symptoms, clinical effects comparison were observed before and after the treatment.Results After 7-days treatment, the cure rate of the treatment group was 95.2%(60/63), and the control group was 73.0%(46/63). Their difference was conspicuous(χ2=17.407,P<0.05). The treatment group attained better curative effects(P<0.05) and got shorter symptomatic relief time of the duration of fever, time of tain disappeared, time of ulcer dissipated and cure time(The T-value is respectively 9.590, 6.983, 5.864, 5.814,P<0.01).ConclusionsYinhuang decoction and external application ofXilei decoction is effective for treating vesicular stomatitis.

Autistic disorder is a severe neuropsychiatric disease and abnormal development in early childhood.The main clinical manifestations of autistic disorder are social interaction,language and behavior barriers.Currently,the incidence trend has showed increased year by year,the pathogenesis of autism has also been considerable development.This paper reviews the latest developments in autism,make excitatory/inhibitory neurotransmitter imbalances,nicotinamide metabolism and HPA axis dysfunction is the main pathogenesis of autism.

Objective To study the related risk factors and comparison between adenomyosis and uterine myoma in order to find the same and different ways of preventing adenomyosis and uterine myoma.Methods Clinical data of 200 cases of adenomyosis and 200 cases of uterine myoma were retrospectively analyzed.Results There was no significant difference in the incidence of different ages between adenomyosis and uterine myoma (P ＞ 0.05).There were significant differences in A blood type,family history,dysmenorrhea and using intrauterine device between adenomyosis and uterine myoma (85 cases vs.56 cases,9 cases vs.36 cases,163 cases vs.71 cases,104 cases vs.79 cases,P ＜ 0.05),but there was no significant difference in occupation,education,previous gynaecopathia inflammatory disease,age of menarche,menstrual cycle,menstruation,infertility,the first gestational age,parity,abortion numbers between adenomyosis and uterine myoma (P ＞ 0.05).Conclusions The adenomyosis and uterine myoma may be associated with the stimulation by high level of female hormone.Compared with uterine myoma,adenomyosis seems to be related to A blood type,dysmenorrhea and using intrauterine device.

It's known that ICU patients is in critical condition and might deteriorate rapidly,so it's important for them to get appropriate nutritional support in order to recover.We must make proper nutrition treatment plan for patients according to their different nutritional condition and potential risk.Nutritional risk screening can not only assess the nutritional status of children,is more likely to predict its potential nutritional risk,to guide nutritional support treatment plan,and ultimately improve the prognosis.Looking out for comprehensive,simple,fast,and easy nutritional risk screening tools as soon as possible and appropriate nutrition risk screening is significantly for growth and development as well as prognosis of ICU patients.

The definition of cancerous toxin and the relationships between cancerous toxin and other factors including the etiopathogenesis, pathogenesis and treatment of malignant tumor were discussed in this paper. The author suggests that the cancerous toxin is engendered by the disequilibrium of human body, which is the foundation of tumorigenesis. Cancerous toxin is the main pathogenic factor or one of the main pathogenic factors during the development of malignant tumor, hence it is also the key point for understanding and treating malignant tumor.

Syndrome research is a challenging field in the research on traditional Chinese medicine and there is no breakthrough at all in this field as yet, although some progresses from various aspects have been achieved in recent years. The definition of syndrome based on the conceptions of traditional Chinese medicine is basically clear, but the qualitative macro-criteria for syndrome are not standardized and the research methods for quantification of such criteria are not unified. These hindered the processing of the modernization of traditional Chinese medicine to a great extent; therefore new research methods for syndrome using techniques of modern sciences should be further investigated. During the research of syndrome, it is suggested that: (1) the research should be turned to complex syndrome from the fundamental simple syndrome gradually, on the basis of certain diseases in western medicine; (2) animal experiment would be of no significance before quite a successful research performed in human body; (3) the results of the research of syndrome should be in agreement with the life science as well as the entire natural science.