Objective:To elucidate the effect of osteogenic growth peptide(OGP) on proliferation and protein synthesis of human PDLCs in vitro.Methods:Human PDLCs were cultured individually in medium contained various concentrations of OGP;and cell proliferation quantity and protein synthesis were examined by MTT and coom asie brilliant blue staining.Results:In vitro,the addition of OGP in cultures resulted in an increase of cell proliferation(P

One hundred and nine cases of female isosexual precocious puberty were reported. Among them 63 cases were true precocious, while 48 pseudoprecocious. Based on the analysis of their clinical characteristics, the etiologic classification and the differentiation between true and pseudo precocious puberty were discussed. In 43 cases of true precocious puberty, Chlormadinone was used without any influence on growth. It was effective to control the menstruation and the development of secondary sexual characteristics in all but two cases who were over 8 years old. Besides, the problem of the final height of precocious girls was also discussed.

Objective:To evaluate the cost-effectiveness of levofloxacin and gatifoxacin in the treatment of lower respiratory tract infections.Method:The clinical data of levofloxacin and gatifoxacin in the treatment of lower respiratory tract infections were collected with the evidence-based medicine method and were evaluated with pharmacoeconomic cost-effectiveness analysis.Result:The cure rates of two drugs were 64.29%(57.70%,70.88%),and 81.43%(70.05%, 92.81%)and the cost-effectiveness ratios were 1.90 and 5.79 respectively.The?C/?E was 20.37.Conclusion:The cost-effectiveness analysis indicated that the cost-effectivenss ratio of levofloxacin is superior to that of gatifoxacin though the cure efficacy of gatifoxacin for lower respiratory tract infections is better.

OBJECTIVE: To observe the renal protective effects of ramipril and atorvastatin used in combination or alone for diabetic nephropathy. METHODS: 54 patients were randomly assigned to receive ramipril 5 mg q.d (Group A), atorvastatin 10 mg q.d (Group B) or ramipri 5mg qd + atorvastatin 10mg q.d (Group C) for 18wk. RESULTS: After 18-week treatment, levels of both urine protein and blood lipid decreased in all the three groups (P0.05). CONCLUSION: Either Ramipril or Atorvastatin alone had satisfactory effect on diabetic neph-ropathy, but a more remarkable protection effect on kidney was noted when they used in combination.

OBJECTIVE:To evaluate the clinical efficacy,safety and status of gemcitabine for non-small-cell lung cancer (NSCLC) systematically.METHODS:Included studies retrieved from Medline,EMbase,Cancerdit,CBM and CNKI were evaluated by two reviewers alone and cross-checked.The Meta-analyses of studies were conducted using RevMan 4.2.2 software.RESULTS:12 studies containing 1,715 patients with NSCLC were included.12 studies were all reported randomly(RCT).Hidden information and application of blind method in therapy were not reported.Results of meta-analysis indicated that:(1)After chemotherapy reaction rate and the level of median disease development in GP therapy (gemcitabine combined with cisplatin) were higher than in GC therapy (gemcitabine combined with carboplatin) with similar median survival time and strong reaction of digestive tract;(2)Reaction rate;the level of median disease development and median survival time in GP therapy than in EP therapy (etoposide combined with cisplatin) but with strong toxicity in bone marrow;(3)Reaction rate of GP therapy was same to NP therapy (vinorelbine combined with cisplatin) with strong toxicity in bone marrow;(4)Reaction rate,median survival time and one-year survival rate in GP therapy were similar to in gemcitabine alone therapy with intense reaction in digestive tract;(5)Reaction rate in VGP therapy (vinorelbine,gemcitabine combined with cisplatin) was higher than in VG therapy (vinorelbine combined with gemcitabine) with strong toxicity in bone marrow but they had same the level of median disease development and median survival time;(6)Reaction rate,median survival time in DG therapy (gemcitabine combined with taxotere) were higher than in taxotere alone therapy with advanced the quality of life and strong toxicity in bone marrow;(7)Reaction rate,median survival time,the level of median disease development and one-year survival rate in therapy of gemcitabine (50 mg?min-1?30 min,i.v) were similar to that of gemcitabine (10 mg?min-1?150 min,i.v) with intense toxicity in bone marrow.17 cases of related death were reported in all researches.CONCLUSION:Gemcitabine has exact clinical efficacy and causes strong toxicity in bone marrow and reaction in digestive tract.

0.05 for both efficacy(?2=16.229 2)and safety(?2=16.672 0).In combined test for efficacy,the combined OR=2.685 1(95% CI:2.388 3～3.018 7) and the test for combined OR showed that ?2=43.835 8(P

AIM: To investigate the relationship between adiponectin gene SNP+45 polymorphism and coronary heart disease(CHD) in south China Han population.METHODS: The nondiabetic CHD patients diagnosed by the coronary angiography were selected as CHD subjects(153 cases),and 73 healthy adults served as normal control subjects.The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was performed to identify the distribution pattern of adiponectin gene SNP+45 in all subjects.The levels of plasma adiponectin were measured by ELISA.RESULTS: The frequency of T/G + G/G genotype and G allele in CHD patients were significantly higher than those in control subjects(P

OBJECTIVE:To evaluate drug utilization of inpatients in neurology department of our hospital.METHODS:Category of drugs,consumption amount,consumption sum and administration time for each person of 853 cases in neurology department of our hospital in 2008 were analyzed retrospectively.RESULTS:Of total 853 inpatients,patients with stroke accounted for 82.8%.The first 3 drugs in the list of consumption amount were Nao'an capsule,folium ginkgo tablet and Shuxuetong injection.The first 3 drugs in the list of consumption sum were Shuxuetong injection,Monosialoganglioside injection and Cobamamide for injection.Aspirin tablet,Nao'an capsule and Cobamamide for injection took up the first 3 places in the list of DDDs.CONCLUSION:Inpatients in neurology department mainly suffer from cerebrovascular disease and are treated with TCM for activating blood and eliminating stasis and nervous system agents,They are also treated various complications such as infection,constipation,hypertension,diabetes and so on.Drug use in the clinic is rational.

OBJECTIVE:To make a systematic review on the efficacy and safety of canagliflozin in the treatment of type 2 dia-betes,and to provide evidence-based reference for clinical treatment. METHODS:Retrieved from Cochrane Library,PubMed,EM-Base,CBM and Wanfang database,randomized controlled trials (RCT) of canagliflozin (test group) versus placebo (control group)in the treatment of type 2 diabetes were collected,and Meta-analysis was performed by using Rev Man 5.2 statistical soft-ware after extracting data and evaluating quality. RESULTS:A total of 7 RCTs were included,involving 2 188 patients. The results of Meta analysis indicated that glycosylated hemoglobin levels [WMD=-0.82,95%CI(-0.99,-0.65),P<0.001],the proportion of HbA1c<7%[RR=2.51,95%CI(1.98,3.19),P<0.001],fasting plasma glucose levels [WMD=-32.91,95%CI(-39.65,-26.17), P<0.001] in test group were significantly better than those of control group,the incidence of genital tract infections was significant-ly higher than control group [RR=3.76,95%CI(2.23,6.35),P<0.001];however,compared with control group,there was no sig-nificant difference in the incidence of hypoglycemia [RR=1.13,95%CI(0.40,3.20),P=0.81] and urinary tract infections[RR=1.19,95%CI(0.82,1.73),P=0.36]. CONCLUSIONS:Canagliflozin is safe and effective in the treatment of type 2 diabetes,and it needs to be noticed with genital tract infections during the clinical use. Due to the limitation of methodology,large-scale and poly-centric RCT are required for further validation of the conclusions.

Comprehensive evaluation for colleges of stomatology is a complex systematic engineering, which is affected by the determination of index and weight. Based on the previous research results,this study establishes a comprehensive evaluation index for colleges of stomatology in China by applying Delphi method,carrying out two-round consultation to 45 experts,which includes 4 first layer indicators and 21 second layer indicators.