Objective To investigate the low doses of 131 iodine on serum Ghrelin levels and serological related indexes in pa‐tients with hyperthyroid .Methods A randomized controlled trials ,96 cases of hyperthyroidism in our hospital were randomly divid‐ed into two groups (group A and group B)according to the ratio of 1∶1 from June 2011 to June 2012 ,48 cases in each group ,and at the same time ,42 cases health people as health control group .The group A were treated with 131 iodine solution 3 .69 -4 .40 MBq/g reatment ,group B was given 131 iodine solution 2 .59-2 .96 MBq/g treatment ,and the serum Ghrelin levels and serological related indicators of two groups patients were statistically analyzed after treatment .Followed up for 2 years ,review of the serum levels of Ghrelin and serological related indexes and compare the incidence of hypothyroidism .Results The serum FT3 ,FT4 and FPG levels of hyperthyroid patients were significantly higher than the health control group (P< 0 .01);conversely ,the serum S‐TSH and Ghrelin levels of hyperthyroid patients were significantly lower than the health control group (P<0 .01) .3 months later after treatment ,the serum FT3 ,FT4 and FPG levels of the hyperthyroidism group B were significantly lower than hyperthyroidism group A(P<0 .05);on the contrary ,the serum Ghrelin and S‐TSH levels were significantly higher and hyperthyroidism group A (P<0 .05);2‐year follow‐up after treatment ,the incidence of hypothyroidism of hyperthyroidism group A were higher and group B ,but without statistical significance(P>0 .05) .Conclusion A low dose of oral 131 iodine solution (2 .59‐2 .96 MBq/g) ,could get a better short‐term efficacy in patients with hyperthyroidism ,high security .

Objective:To investigate the Acinetobacter baumannii’s distribution feature、the antimicrobial resistance of Acinetobacter baumannii isolated during the past 4 years and compare antibacterial activity of Polymyxin B against multidrug-resisitant(MDR) Acinetobacter baumannii with that of Imipenem in vitro.Methods:The distribution feature of infection caused by Acinetobacter baumannii was supervised.Disk diffusion test was used to study the antimicrobial agents resistance of Acinetobacter baumannii and transition of drug resistance.The results were evaluated based on Clinical and Laboratory Standards Institute(CLSI).The MDR Acinetobacter baumannii were screened by WHONET 5.MICs(minimal inhibitory concentration)of Polymyxin B and imipenem were detected by broth dilution method.Results:Constituent ratio of infections caused by Acinetobacter baumannii had been incresed in the recent 4 years,especially in intensive care unit.Although carbapenems were the most active antibiotics tested against Acinetobacter baumannii,the resistance rate had been sharply raised since 2008.In addition,the ratio of MDR Acinetobacter baumannii had also been raised in the 4 years.The results of MIC displayed that Polymyxin B had the higher antibacterial activity against the MDR Acinetobacter baumannii than Imipenem. Conclusion:Proportion of nosocomial infection caused by Acinetobacter baumannii significantly increased.The resistance rate of Acinetobacter baumannii had been rised obviously and the number of MDR Acinetobaeter baumannii had been increased sharply. Monitoring of the antimicrobial agents resistance to Acinetobacter baumannii should be strengthened.Polymyxin B still shows strong antibacterial activity on the MDR Acinetobacter baumannii in vitro.We can consider using Polymyxin B to treat the severe infections caused by MDR Acinetobacter baumannii.

Survivin is the strongest member of the inhibitor of apoptosis protein(IAP)family. Smac is the second mitochondria-derived activator of cysteine proteases,which can promote apoptosis by combining with IAP. Abnormal expression of them is closely related with occurrence,development,treatment tolerance and prognosis of ovarian cancer. It is prompted that Survivin and Smac are expected to play important roles in the early diagnosis and targeted therapy of ovarian cancer.

A growing body of research concerns about the mental psychological intervention involved in the treatment of chronic pain. It still continue reported that combining with mental psychological intervention in pain management could relieve pain level, therefore improve quality of lives. Common psychological intervention including psychological and pharmacological approach and psychological behavior approach both support their efficacy

Objective To evaluate the value of apparent diffusion coefficients (ADCs) in the diagnosis of malignant bone neoplasms.Methods Eighteen cases with consecutive primary malignant bone neoplasms of the knee were prospectively enrolled in the study. Each patient had a controlled preoperative MRI including a SSEPI-DWI sequence. With the help of a pathologist, spatially localized histological sampling study of the postoperative specimens was performed. ADCs of viable tumor (intra- and extraosseous part), peritumoral edema (including soft tissue edema and intramedullary edema), and tumor necrosis of the neoplasms confirmed by spatially localized histological sampling or following up were calculated and compared.Results Mean ADCs of viable tumor, peritumoral muscle edema, peritumoral marrow edema, tumor nerosis, normal muscle, and normal marrow were (1.181?0.236)?10 -3mm2/s (intraosseous part)/(1.158?0.259)?10 -3mm2/s (extraosseous part), (2.347?0.233)?10 -3mm2/s, (1.997?0.119)?10 -3mm2/s, (2.230?0.208)?10 -3mm2/s, (0.486?0.313)?10 -3mm2/s, and (0.483?0.288)?10 -3mm2/s, respectively. Statistical differences were significant among all these tissues (F=153.131, P=0.000). The ADCs of viable tumor were higher than that of normal tissues (P

AIM: To establish a HPLC method for determing paeoniflorin and baicalin in Weichang Heji(Radix Paconiae alba,Radix Scutellariae,Radix et Rhizoma Khei,etc.). METHODS: The column was Ultimate XB-C_(18)(5 ?m,250 mm?4.6 mm),methanol-water-acetic acid(35∶65∶1) as the mobile phase at a flow rate of 1.0 mL/min,the detecting wavelength was at 244 nm. RESULTS: The linear range was within 25 ?g/mL-250 ?g/mL for paeoniflorin and baicalin. The average recovery rate was(98.12%) and 96.81%,respectively.RSD was 1.16% and 0.95%(n=6) respectively. CONCLUSION: The method is simple and accurate.It can be used to determine the contents of paeoniflorin and baicalin in Weichang Heji meantime.

Objective To investigate the FYES and FYX allele expression situation of Duffy blood group in Han population of Nanjing area.Methods The genomic DNA was randomly extracted from peripheral EDTA-K2 anticoagulation blood samples in 200 voluntary blood donors and Duffy blood group FYA and FYB allele typing was performed by PCR-SSP.The EYES and FYX allele sequence charateristics of Duffy blood group were analyzed by adopting Sanger double deoxygenation gene sequencing method.Results The PCR genotyping results were consistent with the sequencing results.Among 200 samples,180 cases were FYA/FYA and 20 cases were FYA/FYB;the sequencing results showed that FYES and FYX allele expression was not been found in 200 samples.Conclusion The expression frequencies of FYES and FYX alleles are extremely low in Han population of Nanjing area,which has significant difference compared with other races.

Objective To establish the quality standard for Yuyuan Mingmu Granula. Methods Radix Et Rhizoma Notoginseng,Fructus Schisanrae Chinesis,Flos Scophorae and Fructus Forsythiae were identified by TLC. The content of loganin was determined by HPLC. Results Under the selected conditions,clear and specific spots were obtained. For content determination,the linear range of loganin was 0.084 ?g～0.840 ?g,r=0.999 9,the average recovery was 98.5 %(n=6)and RSD was 1.29 %. ConcLusion The method is proved to be simple and specialized with a good reproductivity and can be used to control the quality of Yuyuan Mingmu Granula.

Independent component algorithm (ICA) is a method of higher-order statistics(HOS) with the study objects of multivariate random signals that are mutual independent. It aim is to transform multivariate random signal into the signal having components that are mutually independent in complete statistical sense. This article briefly introduce series of the ICA algorisms including second order blind identification, multiple unknown source extraction algorithm based on second-order statistics, as well as Informax, modified Informax, fast fixedpoint ICA and joint approximative diagonalization of eigenmatrix (JADE) algorithm that are based on HOS. At the end of the article, the performance of each algorithm is compared and its application prospect is forecasted.

Purpose:To investigate the rational choice of adjuvant treatment and its clinical value for stage Ⅰb, Ⅱa cervical cancinoma after radical hysterectomy and pelvic lymphadenectomy.Methods:126 patients with stage Ⅰb and Ⅱa cervical cancer received adjuvant radiotherapy and/or chemotherapy after radical hysterectomy and pelvic lymphadenectomy .Of these patients, 64 received radiotherapy only, 26 chemotherapy only, 36 had both. The prognostic factors and treatment results were analyzed.Results:The overall 5-year survival rate for the 126 patients was 73%(92/126). For the radiotherapy only, chemotherapy only, and the radio-chemotherapy groups, the 5-year survival rates were 76.6%(49/64), 69.2%(18/26), and 69.4%(25/36) respectively. The clinical stages and the number of pelvic lymphnodes metastases were the most important prognostic factors. Conclusions:The value of adjuvant treatment for early stage cervical cancer after radical surgery was limited, but for patients who had more than two high risk factors, adjuvant treatment should be given, and at the same time, we should emphasis the importance of thoroughness of radical hysterectomy and pelvic lymphadenectomy.