Objective To observe the clinical curative effect of anticoagulants combined with calcium,vitamin E in pregnancy induced hypertension patients at high risk for early intervention.Methods 113 patients with hypertensive disorder complicating pregnancy were selected as the observation subjects,according to the detection of prethrombotic state before pregnancy,they were divided into observation group one 38 cases,group two 43 cases,control group 32 cases.The observation group one was given intervention preconception,the group two was given intervention during pregnancy,the control group was given intervention when abnormal.The incidence rates of obstetric complication,intrauterine distress and neonatal asphyxia were compared among the three groups.Results The incidence rates of hypertension,obstetric complications,intrauterine distress and neonatal asphyxia in the group one were 5.26％,7.89％,5.26％,5.26％,those in the group two were 20.93 ％,9.3 ％,18.6％,20.93 ％,those in the control group were 43.75％,28.13％,43.75％,48.88％,the differences between the observation group one and control group showed significant differences(x2 =14.59,5.01,14.59,16.36,all P ＜ 0.05),the differences between the group two and the control group were statistically significant (x2 =4.49,4.54,5.60,5.68,all P ＜ 0.05),the incidence rates of hypertension,neonatal asphyxia between the observation group one and group two had statistically significant differences (x2 =4.22,4.22,all P ＜ 0.05).Conclusion Anticoagulants combined with calcium,vitamin E in the treatment of patients with hypertensive disorder complicating pregnancy,can effectively correct the adverse pregnancy outcomes,and improve the prognosis of perinatal infants,and early intervention is better.