1.A Case of Vancomycin-induced Linear IgA Bullous Dermatosis
Won CHOI ; Hyung Jin HAHN ; Ki Bum MYUNG ; Seung Hyun CHEONG
Korean Journal of Dermatology 2019;57(5):288-289
No abstract available.
Linear IgA Bullous Dermatosis
;
Vancomycin
2.A Case of Linear IgA Bullous Dermatosis Associated with Systemic Lupus Erythematosus.
Ho June LEE ; Sook Jung YUN ; Seung Chul LEE ; Jee Bum LEE
Annals of Dermatology 2016;28(5):660-662
No abstract available.
Linear IgA Bullous Dermatosis*
;
Lupus Erythematosus, Systemic*
3.A Case of Linear IgA Bullous Dermatosis Associated with Systemic Lupus Erythematosus.
Ho June LEE ; Sook Jung YUN ; Seung Chul LEE ; Jee Bum LEE
Annals of Dermatology 2016;28(5):660-662
No abstract available.
Linear IgA Bullous Dermatosis*
;
Lupus Erythematosus, Systemic*
4.Dermatitis herpetiformis-like Linear IgA bullous disease in a Filipino
Lauren Camille B. Livelo ; Elisabeth Ryan ; Johannes Dayrit ; Ricky H. Hipolito
Journal of the Philippine Dermatological Society 2020;29(1):100-103
INTRODUCTION: Linear IgA bullous disease (LABD) is a rare autoimmune blistering disease characterized by subepithelial bullae and linear IgA deposition along the basement membrane zone of the epidermis. Lesions present as pruritic papulovesicles and tense bullae which may coalesce forming annular or polycyclic urticarial plaques with blistering on the edge of the lesions forming the classic “string of pearls” sign. Lesions may affect the face, trunk, and extensor extremities. Incidence rates range from 0.5 to 2.3 cases per million individuals per year. Due to its rare occurrence, there are only a fewdocumented reports on cases of LABD, particularly in the Filipino population.
CASE REPORT: A 33 year-old Filipino female consulted because of a 3-week history of severely pruritic vesicles and crusts on the face, trunk, and arms. Patient noted no gastrointestinal symptoms on consultation. Skin punch biopsy revealed subepidermal blisters with collection of neutrophils at the
dermal papillae. Direct immunofluorescence showed strong (+2) deposits of linear IgA at the dermo- epidermal junction in perilesional skin thus validating the diagnosis. The patient’s serum was negative for IgA anti-tissue transglutaminase and IgA antiendomysial antibodies. Patient was treated with topical corticosteroids and Dapsone 50 mgs OD with remarkable improvement.
CONCLUSION: Linear IgA bullous disease has very few reported cases especially in the Philippine setting. Dapsone is considered the first-line treatment. The disease may persist for a decade or longer, and relapses may occur. Careful history-taking accompanied by the histological, immunofluorescence, and serological findings must be done to ensure proper treatment and good prognosis.
Dermatitis Herpetiformis
;
Linear IgA Bullous Dermatosis
;
Immunoglobulin A
5.Drug-induced chronic bullous disease of childhood in a two-year-old Filipino male triggered by cefaclor or cefuroxime: A case report
Sher Claranza O. Liquido ; Maria Jasmin J. Jamora
Journal of the Philippine Dermatological Society 2021;30(1):41-44
Introduction:
Chronic bullous disease of childhood (CBDC) is a rare immune-mediated subepidermal vesiculobullous eruption,
characterized by linear IgA deposition along the basement membrane zone of the skin. Although mostly idiopathic, CBDC may
be triggered by factors such as infection, and drugs. Clinical and immunohistopathological features of drug-induced cases are
heterogeneous and indistinguishable from the idiopathic form.
Case report:
A two-year-old Filipino male presented with pruritic vesicles and bullae on the back several days after finishing a course
of cefuroxime, and cefaclor. Examination revealed multiple tense vesicles and bullae, some coalescing into a rosette pattern with
central crusts on the perioral, scalp, neck, back, perineal, and perianal areas.
Histopathology showed a subepidermal split with neutrophilic and eosinophilic infiltrates. Direct immunofluorescence revealed
strong linear deposition of IgA, and granular deposits of C3 and IgM at the basement membrane zone, thus confirming the di-
agnosis of CBDC.
Dapsone at 2mg/kg/day was started, with oral prednisolone (1.3mg/kg/day), and cloxacillin syrup (40mg/kg/day). Topical care
with betamethasone dipropionate and mupirocin ointment was included. After eight weeks, patient showed significant im-
provement with few vesicles and resolved lesions healing with post-inflammatory hyperpigmentation.
Conclusion
We report a case of a two-year-old male presenting with vesiculobullous lesions after a course of cefuroxime,
and cefaclor. As both were given and withdrawn in a period of close proximity, it is difficult to determine the probable culprit
drug. Spontaneous resolution upon withdrawal of the suspected drug is variable. Systemic therapy such as dapsone may be
necessary for treatment.
Linear IgA Bullous Dermatosis
;
Cefaclor
;
Cefuroxime
6.Vancomycin Induced Linear IgA Bullous Dermatosis.
Sunhee KIM ; Jung Hwan HWANG ; Ji Hyun YI ; Chang Seop LEE
Korean Journal of Medicine 2011;80(2):162-163
No abstract available.
Blister
;
Immunoglobulin A
;
Linear IgA Bullous Dermatosis
;
Skin Diseases
;
Vancomycin
7.A Case of Fulminant Linear IgA Bullous Dermatosis in an adult.
Soo Lieon PARK ; Chull Wan IHM
Korean Journal of Dermatology 1995;33(4):748-754
The linear IgA bullous dermatosis is a rare chronic vesicobullous disease resembling dermatitis herpetiformis or bullous pemphigoid. We report a case of linear IgA bullous dermatosis developed in a 16 year old female, whose cutaneous lesions were unusually acute. The urticarial wheals started on her buttock and spread to her entire body in two hours and generalized blistering de veloped within four days, The response by dapsone was also dramatic. Routine histological and both direct and indirect immunofluorescent microscopic findings were typical of linear IgA bullous dermatosis.
Adolescent
;
Adult*
;
Blister
;
Buttocks
;
Dapsone
;
Dermatitis Herpetiformis
;
Female
;
Humans
;
Linear IgA Bullous Dermatosis*
;
Pemphigoid, Bullous
8.A case of Linear IgA Bullous Dermatosis Probably Caused by Vancomycin.
Hyun Woo CHIN ; Ho Sun JANG ; Ju Hyun JO ; Moon Bum KIM ; Chang Keun OH ; Kyung Sool KWON
Korean Journal of Dermatology 2005;43(3):416-418
Linear IgA bullous dermatosis (LABD) is an uncommon acquired autoimmune subepidermal bullous disease characterized by the linear deposition of IgA at the basement membrane zone. Although LABD is most often idiopathic, drug-induced LABD may, occur in rare occasions. We report a case of vancomycin-induced LABD in a 70-year-old woman with septic arthritis on the right knee.
Aged
;
Arthritis, Infectious
;
Basement Membrane
;
Female
;
Humans
;
Immunoglobulin A
;
Knee
;
Linear IgA Bullous Dermatosis*
;
Vancomycin*
9.A case of drug - induced linear IgA bullous dermatosis.
Sang Hee HAM ; Seog Jun HA ; Young Min PARK ; Sang Hyun CHO ; Jin Wou KIM ; Baik Kee CHO
Journal of Asthma, Allergy and Clinical Immunology 1998;18(3):504-509
Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease characterized on direct immunofluorescence of perilesional skin by the linear deposition of IgA at the basement membrane zone. The pathogenesis of LABD is not known, but rar ely some cases of LABD have been reported in association with drug exposure. We report a case of drug-induced LABD showing linear deposits of IgA and IgG at the basement membrane zone on direct immunofluorescence of perilesional skin as well as typical clinical and histologic characteristics, although the causative agent could not be specified.
Basement Membrane
;
Blister
;
Fluorescent Antibody Technique, Direct
;
Immunoglobulin A
;
Immunoglobulin G
;
Linear IgA Bullous Dermatosis*
;
Skin
10.Linear IgA Bullous Dermatosis.
Hong Jig KIM ; Young Keun KIM ; Hyung Chan PYO ; Chang Woo LEE
Korean Journal of Dermatology 1987;25(4):525-530
A case of linear IgA bullous dermatosis reported. A 32-year-old male with pruritic, papulovesicular eruptions on the whole body of 2 months' duration was examined. He had no history of diarrhea or fou]smellirig stool even though his diet cnntained gluten. A skin biopsy revealed subepidennal vesicles and papillary microabscesses infiltrated by many neutrophils and some eosinophils. Direct irnmunofluorescent examination of the perilesional skin showed a linear deposition of IgA along the basement mernbrane zone. The lesions responded rapidly to oral dapsone and topical steroid therapy but recurred whenever the oral mcdication was discontinued.
Adult
;
Biopsy
;
Dapsone
;
Diarrhea
;
Diet
;
Eosinophils
;
Glutens
;
Humans
;
Immunoglobulin A
;
Linear IgA Bullous Dermatosis*
;
Male
;
Neutrophils
;
Skin