Objective To study the relationship between B-type natriuretic peptide(BNP) and type 2 diabetes mellitus(DM) patients with congestive heart failure(CHF).Methods 78 patients with DM were divided into pure DM group(n=37) and DM+CHF group(n=41) ,the level of plasma BNP in patients with DM(n=78) and normal control group(n=20) was.measured.Results The level of plasma BNP in grade Ⅱ ,Ⅲ～Ⅳgroup of cardiac function were significantly higher than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly higher than that in grade II group(P<0.05),LVEF in Ⅱ,Ⅲ～Ⅳgroup of cardiac function were significantly lower than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly lower than that in grade Ⅱ group(P<0.05) ;The level of plasma BNP was positively related to LVEF(r= -0.713,P<0.05).Conclusion BNP was an objective indicator to evaluate the severity of DM with heart failure.

Objective To study the effects of trimetazidine on cardiac function in type 2 diabetes mellitus patients with heart failure. Methods Ninty type 2 diabetes mellitus patients with heart failure were randomly divided into two groups (45 patients in control group,45 patients in treatment group). All patients in both two groups received routine therapy in order to have blood glucose under control,the treatment group was treated with trimetazidine 20mg po Tid ,treatment for 6 months. Before and after treatment ,two groups were detected left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD) and left ventricular ejection fraction (LVEF), and the clinical efficacy were evaluated. Results Ater treatment, the rate of total efficiency was 68. 9% in control group, and it was 86. 7% in treatment group. The clinical efficacy of treatment group was significantly better than control group(P＜0.05) ;Ater treatment,LVEDD,LVESD were significantly reduced than those before treatment(P ＜0.05) ,LVEF was significantly higher than that before treatment (P ＜0.05);After treatment,LVEDD, LVESD in treatment group was significantly reduced than those in control group, LVEF was significantly higher than control group (P ＜ 0.05).Conclusion Trimetazidine can significantly improve the cardiac function in type 2 diabetes mellitus patients with heart failure.

Purpose:To study the expression of Ki-67 antigen in normal mucosae,benign and malignant neoplasms of colorectum and its clinical significance. Methods:33 cases of carcinomas,13 cases of benign neoplasms and 13 cases of normal mucosae of colorectum were collected. Ki-67 antigen was detected using flow cytometry.Results:The Ki-67 antigen positive fraction of normal mucosae,benign and malignant neoplasms of colorectum were 2.65%?1.51%,6.38%?2.51%,18.52%?8.53% respectivly, there being significant difference between the groups(P0.05). Conclusions:Ki-67 antigen expression is a valuable marker to distinguish the normal mucosae,benign and malignant neoplasms of colorectum. Ki-67 antigen expression has no relation with tumor size,type of histopathology,Dukes stage,location,length of illness history,age,sex of the colorectal carcinoma patients.

Endometrial blood flow is directly related to endometrial receptivity thereby affecting in vitro fertilization and embryo transfer (IVF-ET) outcomes. In recent years a growing number of studies have shown that traditional Chinese medicine (TCM) can play a role to improve endometrial blood flow and embryo transfer. Studies have confirmed that formulas based on reinforcing kidney and activating blood can promote the formation of uterine endometrial blood vessels by adjusting expressions of a variety of vessel growth factors, and regulating nitric oxide level for inhibition of vascular smooth muscle contraction of the uterus. Treatments based on differentiation of syndromes are key to the theory of TCM. Differentiation of syndromes should be combined with biomedical disease diagnosis. It is also necessary to further clarify other endometrial blood flow disorders using TCM diagnostic methods. In these cases, drugs for reinforcing kidney and activating blood are relevant, but other medicines for smoothing liver qi and nourishing blood, as well as tonifying the spleen and generating blood may also be effective. Future clinical studies should focus on the observation of different types of TCM syndromes and the research on compatibility ratio and dose-dependent relationship of Chinese medicines. Acupuncture has been used during IVF-ET for more than 10 years. Electro-acupuncture can control the expansion of the uterine arteries by inhibiting the sympathetic nerves. However, acupuncture has not been proved to regulate endometrial arteries. To sum up, TCM can be applied to improve endometrial blood flow so as to increase birth rates in IVF-ET. The combination of Chinese and Western medicines and acupuncture application will increase their combined effect, thereby obtaining greater clinical benefits.

Objective To test the reliability and validity of the Chinese Version of the Depressive Cognition Scale (DCS) among the older people.Methods The sample consisted of 570 old people,collected by a demographic questionnaire,the Chinese version of DCS,and the Center for Epidemiological Studies Depression Scale (CES-D),then all the data was analyzed by SPSS 21.0.Results The item-to-total correlation coefficients of DCS ranged from 0.65 to 0.84 (P＜0.01),and the average coefficient was 0.77.The content validity index(CVI) was 0.88.The result of exploratory factor analysis (EFA) was that one factor explained 59.72％ of the total variances,and the concurrent validity between DCS and CES-D was positive related (r=0.24-0.82,P＜0.01).Regarding CES-D as the gold standard,the sensitivity was 84.7％ and the specificity was 90.7％.The inter-item correlation coefficients of DCS ranged from 0.40 to 0.73 (P＜0.01);the Cronbach α was 0.82,and the retest reliability (intra-class correlation coefficient,ICC) was 0.92 (95％CI=0.86-0.95,P＜0.01).Conclusion DCS is proved to be a reliable and valid instrument,and it can be used to assess the depressive cognition and screen the early depressive symptoms of Chinese old adults.

Objective To test the reliability and validity of the Chinese version of the sense of coherence (SOC) scale (13-items) among the older people.Methods A random sample of 1 032 old adults was selected from community in Jinzhou,Shenyang,Dalian of Liaoning.A demographic questionnaire,the SOC-13 scale,the WHO-5 and the Center for Epidemiological Studies Depression Scale (CES-D) were used to collect the data.All the data was analyzed by SPSS 21.0 and AMOS17.0.Results The item-total correlation coefficients of SOC-13 ranged from 0.625 to 0.760 (P＜ 0.01).The result of exploratory factor analysis (EFA) was that three factors explained 74.745％ of the total variances,and the CFA confirmed the hypothesized three-factor model.SOC scale had an ideal criterion(x2/df =2.908,CFI =0.975,GFI =0.949,NFI =0.963,IFI=0.975,RMSEA=0.061).Criterion related validity test showed that the total score of SOC-13 was negatively correlated with CES-D(r=-0.55,P＜0.01),and positively correlated with WHO-5 (r=0.73,P＜ 0.01).SOC-1 3 had a Cronbach's α of 0.916,the Guttman split-half coefficient was 0.828,and the retest reliability (intra-class correlation coefficient,ICC) was 0.872 (P＜0.01).Conclusion SOC-13 is a reliable and valid instrument,which can be used to measure the lever of sense of coherence among Chinese old adults.

Objective To investigate the clinical features, diagnostic criteria and treatment of primary pulmonary lymphoma (PPL). Methods 11 patients with PPL, the diagnosis of which was made with pathological study of biopsy specimen, admitted from 1997 to 2006 to General Hospital of PLA, were retrospectively analyzed. The data collected for the present study, combined with some references, were reviewed concerning the clinical characteristics, X-ray features, pathologic features, bronchoscopic observations, diagnostic criteria as well as treatment. Results PPL was a rare disease, and was hard to have a definite diagnosis for lack of specific clinical symptoms. The most common clinical symptoms of PPL were cough, chest distress, fever etc. X-ray features included solitary or multiple nodules, ground-glass opacity, filamentous shadow and consolidation shadow. Such signs could be seen at the same time, commonly accompanied with air bronchogram. No distinct changes could be found in bronchofibroscopy. Final diagnosis of PPL could be made when a CT guided biopsy was done, followed by pathological examination with immunohistological study, or study of the tumor after surgery. Surgical operation and chemotherapy were the major effective therapeutic approach for the treatment of PPL. Prognosis was favorable in patients with low degree of malignancy of the tumor. Conclusion The clinical characteristics and X-ray image of PPL are not specific. Misdiagnosis occurs commonly. The final diagnosis of PPL depends on the pathologic examination of the PPL tissue. Appropriate CT guided biopsy is necessary for an early diagnosis. Surgery as well as ancillary chemotherapy after operation could get satisfactory results.

Objective To evaluate the characteristics of the haemodynamics of the hysteromyoma and its diagnosis value. Methods To apply the transvaginal color doppler ultrasound to detect the blood flow parameters of the uterine artery and the muscular tumor’s peripheral and inner area from 68 patients with hysteromyoma, compared with the blood flow parameters of the uterine artery from 50 normal women so as to analyze their difference. Results (1) In the hysteromyoma group, the maximum blood flow velocity during the systolic phase (SP) and the minimum blood flow velocity during the end-diastolic phase (ED) of uterine artery are significantly higher than those in the normal group(P

[Objective] To discuss the clinical significance of simple synovial tuberculosis treated and diagnosed by arthroscopy. [Methods] A review study of 8 patients with simple synovial tuberculosis from September 1998 to September 2004. The 8 cases with the main clinical manifestation of articular swelling were confirmed as simple synovial tuberculosis by arthroscopic examination and arthroscopic synovectomy in pathology. [Results] The 8 cases were definitely diagnosed by arthroscopy pathologically. The average follow-up period was two years and four months. For all of the 8 cases, the articular symptoms disappeared, articular function recovered well and the therapeutic effect was satisfactory. [Conclusion] Arthroscopic examination is an effective method to diagnose synovial tuberculosis at early stage. Synovectomy with arthroscopy can remove the pathological synovial membrane and is beneficial to the control of the local tubercular focus.