The late-preterm infant refers to the infant who is born at 340/7 through 366/7 week's gestation.In recent years,the number of the late-preterm continually ascends and the proportion of them in the preterm group increase as well.Recent studies find that the rates of morbidity and mortality of late-preterm infants are much higher than those of term infants.The rise of the proportion of the former and the more medical resources consumed attract the considerable attention thereby.In this article,we will review late-preterm infants' morbidity of several systems and its influential factors in order to provide more information for perinatal medical staff to improve diagnosis,treatment and further research.

OBJECTIVE:To establish a method for content determination of dihydroartemisinin in Dihydroartemisinin and piper-aquine phosphate tablets. METHODS:HPLC was performed on the column of Waters YMC-Pack ODS-AQ with mobile phase of acetonitrile-water(gradient elution)at the flow rate of 1.0 ml/min,the detection wavelength was 216 nm,column temperature was 30℃,and injection volume was 20 μl. RESULTS:The linear range of dihydroartemisinin was 0.009 650-1.930 mg/ml(r=0.999 9);RSDs of precision,stability and reproducibility tests were no more than 0.5%;average recovery was 100.76%(RSD=0.95%,n=9). CONCLUSIONS:The method is simple,rapid and accurate,and can be used for the content determination of dihydroartemis-inin in Dihydroartemisinin and piperaquine phosphate tablets.

The formation and progression of tumor is inseparable from the changes of cell cycle regulatory proteins.The G2-M period block effect of tumor cells is especially important in slowing the growth of tumor and improving the curative effect.DNA damage receptor,signal transduction factor and effectors are the classical pathways to mediate G2 phase arrest of tumor cells,and have the potential to be new targets for tumor therapy.

The technology,of extracting Semen Cassiae from Jueming Jiangzhi Powder was investigated.The perceutages of extra ction and preservation of anthraquinone were used to select the methods of extra ction, concentration and drying of Semen Cassiae. The optimal procedure was set as follows:the large-size powder of Semen Cassiae was extracted with 50% alcohol for three times, then the extracted liquid was concentrated by vacuum evaporati on and finally dried by spraying.

Objective To investigate the expression and significance of hypoxia-inducible factor 1 alpha (HIF- 1α), vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) in tissues of condy- loma acuminatum (CA) in pregnant women. Methods Tissue specimens were obtained from the lesions of 30 pregnant women with CA and 30 non-pregnant women with CA, and from the vulva of 15 normal preg- nant women. By immunohistochemical staining, the expressions of HIF -1α, VEGF and Ang-2 were detected in these specimens. Results The expression rates of HIF -1α,VEGF and Ang-2 were 86.67%, 93.33% and 83.33% in pregnant women with CA, respectively, 63.33%, 66.67% and 53.33% in non-pregnant women with CA, respectively, and 0, 6.67% and 0 in normal women, respectively. Enhanced expressions of HIF -1α,VEGF and Ang-2 were observed in pregnant women with CA compared with the latter two groups (P < 0.05). In pregnant women with CA, a significant correlation was noted between the expression of HIF -1α and VEGF (r = 0.412, P < 0.01) and between the expression of Ang-2 and VEGF (r = 0.460, P < 0.01). Further more, the expression of HIF -1α, VEGF and Ang-2 positively correlated with each other in non-preg- nant women with CA. Conclusion In tissues of CA in pregnant women, HIF-1α,Ang-2 and VEGF are over expressed, which may be related to angiogenesis.

Objective:To investigate the alveolar bone defects of anterior alveolar bone in patients with bimaxillary protrusion by using cone-beam computed tomography ( CBCT ) . Methods: The samples consisted of 50 patients with bimaxillary protrusion, who were assigned to the teenage group[20 cases, (13. 1 ± 1. 0) years] and adult group[30 cases, (22. 9 ± 4. 2) years] . The adult group included 9 hy-po-divergent, 11 normo-divergent and 10 hyper-divergent patients. The images were obtained by using NewTom VG CBCT and the alveolar defects were evaluated. Results:The ratio of the patients had alveo-lar bone defects was 94. 00%. Meanwhile, the defects were associated with 38. 60% of all the teeth. Most defects occurred on labial alveolar bone ( 98 . 66%); fenestration was found more in the maxillary alveolar region and dehiscence occurred more in the mandible. The dehiscences (3. 06%) and defects prevalence (30. 13%) of the teenage group were significant lower than those of the adult group (11. 73% vs. 42. 46%), P<0. 05; while there was no significance of the fenestrations prevalence between the two group (P>0. 05). The hypo-divergent group had lower fenestrations prevalence (22. 22%) than the normo-divergent (33. 84%) and hyper-divergent groups (37. 50%), P<0. 05. The upper central incisor had the lowest alveolar bone defect prevalence. Conclusion: Alveolar bone defects are common findings in patients with bimaxillary protrusion before orthodontic treatment. The prevalence of defects is affected by age and vertical-growth type.

As one of the treatment options for early stage NSCLC,stereotactic body radiation therapy (SBRT)is mainly applied to the inoperable patients.Compared with small doses of traditional fractionated radi-ation treatment,SBRT are taken a single high dose of radiation.A large body of experience has been accumula-ted over the years and the mathematical model to describe survival in high dose range typically used in SBRT and the best dose of segmentation model were focused on,but there has not yet reached a consensus.Studies show that SBRT has certain advantages in local control ratio and adverse reaction compared with traditional radiotherapy,which can be used in operable patients in the future.

Objective:To find a better way to protect the security and interests of vulnerable groups by exploring the problem of protecting the vulnerable groups in drug clinical trial from the perspectives of ethics committees,organization and researchers.Methods:According to the relevant literature and the actual situation of the hospital,this paper analyzed the security issues of vulnerable groups comprehensively.Results:Only the ethics committees,organization and researchers work together,can it protect the security and interests of vulnerable groups to the greatest extents.Conclusion:Further research on the security of vulnerable groups not only promotes the development of human health,but also plays a decisive role in improving the protection of subjects in drug clinical trial.

In this paper,based on the present situation of the pharmaceutical education in China,the author brings forward the challenge and opportunity to pharmaceutical education at medical colleges,and then gives us some helpful ideas to solve the problems.

DNA methylation is one of the regulators on the expression of genes,and the expression of genes can be ”silenced” by hypermethylation of the tumor suppressor genes,which is in close relationship with carcinogenesis.Gastric cancer is caused by multiple factors and multiple genes alteration and prolonged interaction.among them ,There is considerable relation between the hypermethylation of the tumor suppressor genes and the gastric carcinogenesis.