Objective To investigate the evaluation of serum cystatin C and treating efficacy of enalapril for contrast induced nephropathy after percutaneous coronary.intervention.Methods 86 patients who need coronary angiography or coronary stents implantation by skin were divided into observation group(43 cases)and control group(43 cases)randomly.The fasting venous blood was extracted and in which Cys-C and Scr were tested.All the patients were given water therapy,and enalapril was added in observation group.Diversification of concentration of Cys-C and Scr and efficacy of enalapril were recorded.Results There was no difference of Cys-C and Scr in serum and eGFR before and after operation(all P＞0.05),and the concentration of BUN was(3.96±0.89)mmol/L,which was lower after operation(P＜0.05),and the rate of CIN incidence was 2.33 ％(1 case).The concentration of Cys-C in serum was(18.4±0.58)mg/L,which was significantly higher than preoperation(P＜0.05),and there was no significant difference of Scr,eGFR and BUN before and after operation(P＞0.05),and the rate of CIN incidence was 11.63％(5 cases).Conclusion Cys-C was more sensitive in early detection for contrast induced nephropathy and more convenient.The rate of CIN incidence could be decreased by using enalapril.

This is a case report of a 7-year-old boy who presented with lower limb pain. He was initially presumed to have growing pains but was subsequently diagnosed with acute lymphoblastic leukaemia (ALL). This case highlights the important clinical presentations and differential diagnoses of ALL that a family physician should be cognizant about to avoid misdiagnosis. It also demonstrates the importance of understanding the patient and family's perspectives when evaluating a child with lower limb pain. This enables us to anticipate and meet their needs.

Objective:To find a better way to protect the security and interests of vulnerable groups by exploring the problem of protecting the vulnerable groups in drug clinical trial from the perspectives of ethics committees,organization and researchers.Methods:According to the relevant literature and the actual situation of the hospital,this paper analyzed the security issues of vulnerable groups comprehensively.Results:Only the ethics committees,organization and researchers work together,can it protect the security and interests of vulnerable groups to the greatest extents.Conclusion:Further research on the security of vulnerable groups not only promotes the development of human health,but also plays a decisive role in improving the protection of subjects in drug clinical trial.

Objective To investigate the significance of MMP-3 and IL-15 in the patients with ankylosing spondylitis (AS).Methods The serum levels of MMP-3,IL-15,TNF-? and CRP of 45 patients with AS and 31 healthy controls were tested by sandwich ELISA.The results between the 2 groups were compared each other.Results Significantly increased serum levels of MMP-3,TNF-? and CRP were found in AS patients as compared to those in healthy controls(P

ObjectiveTo analyze the factors related to the operation treatment effectiveness of lumber intervertebral discprolapse.MethodsThe data of 442 patients with lumber intervertebral discprolapse and treated by operation were analyzed retrospectively.Results442 patients had results of excellent in 319 cases (70.3%), good in 89 cases (20.2%), fair in 27 cases (6%), and poor in 7 cases (3.5%), the rate of re-operation was 2.9% (13 cases).ConclusionThe operation treatment of lumber intervertebral discprolapse must be performed after having precise diagnosis, surgical operation adaptation and suitable operation methods and enhancing nursing and recovery should be taken after operation in order to get a satisfactory effectiveness.

Objective To determine the change of maternal heart rate during the treatment with ritodrine for threatened premature labor. Methods110 cases of threatened premature labor were chosen. The ritodrine 100mg in 5% G. S 500mL was intravenously administered. The initial dosage was 6 drops/min, and the dose was increased until uterine contractions were inhibited. The treatment lasted for 40 to 48 hours after the uterine contractions were inhibited, then the oral tablets was recommended. If necessary, repeated treatment was given to some patients. The maternal heart rate was recorded in the whole process of treatment and was compared with the dosage administered. The labor time, fetal weight and Apgar′s score were also analyzed. Results The maternal basic heart rate was increased at first and then decreased. The increasing significantly increased( P ＜ 0.01 ) when the uterine contraction was inhibited. , but no difference showed among the groups of different gestational age( P＞0.05 ). The maternal heart rate was increased with the increasing of ritodrine( max. 140/min). labor time was significantly prolonged with the treatment of ritodrine( P＜0.01 ) ,while that of the idiopathic premature labor was prolonged most obviously ( P ＜ 0.05 ). Average fetal weight was (2.42 ± 0.49) kg, and the average Apgar′s score was≥8. Conclusion In the treatment of inhibiting uterine contractions,the increasing of maternal heart rate caused by ritodrine can be used as an indicator of therapeutic effect.

BACKGROUND:As a good candidate for bioresorbable bone graft, carbonate apatite monolith can be prepared by sintering procedure;however, sintering can cause carbonate loss and result in a much lower rate of
biodegradation compared to the human bone, thereby influencing the formation of new bone.
OBJECTIVE:To fabricate low-crystal inity carbonate apatite monolith as bone graft and test its properties. METHODS:Calcium carbonate monolith prepared by carbonation of Ca(OH) 2 monolith was treated in 1 mol/L
RESULTS AND CONCLUSION:The calcium carbonate completely transformed into low-crystal inity B-type
carbonate apatite after treated for 14 days. Diametral tensile strength of the final product was (10.27±1.08) MPa, which is adequate as a reconstruction material for bone defect. The carbonate content was (4.80±0.50)%, similar to that of the nature bone. The molar Ca/P was 1.63±0.01, indicating the Ca-deficient carbonate apatite is
obtained. The present method al ows an easy fabrication of low-crystal inity B-type carbonate apatite block with adequate strength and without sintering process.
ammonium dihydrogen phosphate solution at 60 ℃ up to 14 days. Diametral tensile strength was examined for biomechanical properties;X-ray diffraction analysis, Fourier transform infrared spectroscopy, scanning electron microscope observation and chemical analyses (carbonate, calcium and phosphate content) were also performed for physical and chemical properties.

OBJECTIVE:To prepare Shuansaitong capsules and establish a method for its quality control.METHODS: Distillation method was applied to extract volatile oil from volatile oil-containing medical material and water decoction method was used to extract physic liquor from other medical material. Suitable quantity of excipients was added to prepare Shuansaitong capsules.Qualitative identifications of Ligusticum chuanxiong,Panax quinquefolium,Salvia miltiorrhiza,Angelica sisensis were performed by TLC,and the content of Gastrodin was determined by HPLC.RESULTS:The quality of Shuansaitong capsules was completely in conformity with the related requirements of China Pharmacopeia.The TLC spots were clear,well-separated,specific and free from interferonce of negative sample.The linear range of gastrodin was 0.1～0.5 ?g with a correlation coefficient of 0.999 5.The average recovery was 96.59% with RSD=0.47% (n=6).CONCLUSION:The preparation technology of Shuansaitong capsules is simple and the determination result was accurate,thus suitable for the preparation and quality control of Shuansaitong capsules.

Objective To evaluate the prognostic value of the first documented rhythm in patients with in-hospital cardiac arrest.Methods The clinical data of 62 in-hospital cardiac arrest patients collected from May 2011 to April 2016 were reviewed.Multiple regression analysis was performed for determination of the factors relevant to ROSC.The patients were divided into defibrillative rhythm group [ventricular fibrillation (VF) /ventricular tachycardia (VT)] and non-defibrillative rhythm group [pulseless electrical activity (PEA) /asystole] according to the first documented rhythm after cardiac arrest.The differences in rate of restoration of spontaneous circulation,number of survival at hospital discharge and those discharged with favorable neurological outcome were compared between groups.Results Logistic regression analysis showed that non-defibrillative rhythm was related to low rate of ROSC.Rate of ROSC (x2 =6.90,P =0.01),number of survival at hospital discharge (x2 =10.49,P =0.00) and those discharged with favorable neurological outcome (x2 =14.70,P =0.00) were higher in the defibrillative rhythm group,while there was no difference in outcomes between the VF and VT groups.There was no difference in consequence found between the PEA and asystole groups.Conclusion Rate of restoration of spontaneous circulation,number of survival at hospital discharge and those discharged with favorable neurological consequence were higher with defibrillative initial rhythm.

Objective To analyze the quality control of the conformal radiotherapy for nasopharyngeal carcinoma. Methods Using BJ-6 6MV linear accelerator, STAR -2000 3D TPS and immobilization device, the patient of nasopharyngeal carcinoma were treated by the conformal radiotherapy. Results Adopting individualized compatibly-shaped face masks and CT scanning (2mm interval, 2mm thickness), three dimensional data of the target and the other tissues were acquired. The conformal radiotherapy was designed in planning system. At the treatment, the target volume was put on the isocenter of the linear accelerator by the customized patient positioning. Conclusion Because the nasopharyngeal carcinoma is located in a special area and it is surrounded by some important organ, in the conformal radiotherapy, the quality control of the CT immobilization technique and the customized patient positioning is very important. This can ensure effective and safe irradiation for the small target volume while excessive irradiation is avoided in other surrounding organs.